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        Selenoproteins and selenium speciation in food.

        Hoac, T.; Lundh, T.; Onning, G.; Akesson, B. (Zhejiang University Press : Springer, 2012)
        Different forms of selenium may have varying bioavailability and may also have different effects on body physiology. For these reasons we have studied the occurrence of different forms of selenium in some foods. The pattern of soluble selenium compounds in different species of fish varied markedly as studied by size-exclusion chromatography coupled to ICP-MS or GFAAS. Most flatfish contained mainly low-molecular-weight selenium compounds while other fish species contained more protein-bound selenium. Studies of muscle from seven meat animal species showed four major selenium peaks as found by size-exclusion chromatography. The second and third peaks probably corresponded to glutathione peroxidase (GPx) and selenoprotein W, respectively, and they contained 85% –100% of the recovered selenium. The distribution among the four peaks of soluble selenium varied considerably among muscles from different species. In other experiments, several factors were found to affect the activity of GPx in tissues such as species differences, tissue specificity and heating. In bovine milk, another selenium-rich food, GPx3 is the only identified selenoprotein so far. Bovine whey was found to contain most of the selenium in β-lactoglobulin, α-lactalbumin and selenomethionine. Supplementation of the cow’s feed by yeast selenium increased the proportion of selenium in the former two fractions. It can be concluded that different animal foods contain a variety of selenium compounds and that the selenium profiles of fish, meat and milk differ markedly and also show species differences. The role of this diversity for the bioavailability of selenium from different foods and the effects of different forms of selenium on the organism need to be explored.
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        Phase I enzyme genotypes and their toxicologically relevant phenotypes.

        Godschalk, Roger; van Schooten, Frederik Jan (Nofer Institute of Occupational Medicine, 2008)
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        Phase II enzyme genotypes and their toxicologically relevant phenotypes.

        Hirvonen, Ari (Nofer Institute of Occupational Medicine, 2008)
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        Dose response and potential thresholds in gene expression.

        van Delft, Joost (Nofer Institute of Occupational Medicine, 2008)
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        DNA repair enzyme genotypes and their toxicologically relevant phenotypes.

        Aka, Peter; Mateuca, Raluca; Kirsch-Volders, Micheline (Nofer Institute of Occupational Medicine, 2008)
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        Mendelian randomization.

        Brennan, Paul; Hung, Rayjean (Nofer Institute of Occupational Medicine, 2008)
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        Dose response and potential thresholds in DNA adduct formation.

        Segerback, Dan (Nofer Institute of Occupational Medicine, 2008)
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        Dose-response relationships and potential thresholds in the induction of mutagenesis and the influence of DNA repair and cell cycle progression.

        Souliotis, Vassilis L.; Kyrtopoulos, Soterios A. (Nofer Institute of Occupational Medicine, 2008)
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        Dose-response and potential thresholds in tumour development.

        Oesch, Franz; Weiss, Carsten; Dietrich, Cornelia; Oesch-Bartlomowicz, Barbara (Nofer Institute of Occupational Medicine, 2008)
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        Dose response and potential thresholds in activation and inactivation of procarcinogens.

        Henderson, Colin J.; Paine, Mark J.I.; Friedberg, Thomas; Wolf, Charles Roland (Nofer Institute of Occupational Medicine, 2008)
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        Dose response and potential thresholds in proliferation and cell survival and death.

        Mateuca, Raluca; Decordier, Ilse; Cundari, Enrico; Kirsch-Volders, Micheline (Nofer Institute of Occupational Medicine, 2008)
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        Bioactive components in foods.

        Manson, Margaret M.; Linseisen, Jakob; Rohrmann, Sabine; Sotiroudis, Theodore G.; Kyrtopoulos, Soterios A.; Hayes, John D.; Kelleher, Michael O.; Eggleston, Ian M.; de Kok, Theo M.; van Breda, Simone G.; et al. (The Nofer Institute of Occupational Medicine, 2007-04)
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        Vitamins and selenium.

        Dragsted, Lars O.; Loft, Steffen; Moller, Peter; Cook, Marcus S.; Rozalski, Rafal; Olinski, Ryszard; Linseisen, Jakob; Abbas, Sascha; Akesson, Bjorn; Bruzelius, Katharina; et al. (The Nofer Institute of Occupational Medicine, 2007-04)
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        Introduction.

        Akesson, Bjorn (The Nofer Institute of Occupational Medicine, 2007-04)
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        Validation of biomarkers: application to examples.

        Gallo, Valentina; Phillips, David; Rohrman, Sabine; Linseisen, Jakob; Kovacs, Katalin; Gyorffy, Erika; Anna, Livia; Schoket, Bernadette; Loft, Steffen; Moller, Peter; et al. (The Nofer Institute of Occupational Medicine, 2007)
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        The epidemiological theory: principles of biomarker validation.

        Vineis, Paolo; Gallo, Valentina (The Nofer Institute of Occupational Medicine, 2007)
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        Introduction.

        Kyrtopoulos, Soterios (The Nofer Institute of Occupational Medicine, 2007)
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        Challenges from new technologies and new biomarkers.

        Vineis, Paolo; Vermeulen, Roel; Geneletti, Sara; Minelli, Cosetta; Taioli, Emanuela; Thompson, John; Stromberg, Ulf; Kirsch-Volders, Micheline; Raluca, Mateuca; Matullo, Giuseppe (The Nofer Institute of Occupational Medicine, 2007)
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        State of validation of biomarkers of carcinogen exposure and effect. Food-chemical-specific biomarkers.

        Rohrmann, Sabine; Linseisen, Jakob; Phillips, David H.; Seidel, Albrecht; Venitt, Stan; Georgiadis, Panos; Segerback, Dan; Hashibe, Mia; Balbo, Silvia; Boffetta, Paolo; et al. (The Nofer Institute of Occupational Medicine, 2007)
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        State of validation of biomarkers of carcinogen exposure and effect. Generic biomarkers.

        Phillips, David H.; Venitt, Stan; Jonsson, Bo A.G.; Farmer, Peter; Mateuca, Raluca; Kirsch-Volders, Micheline; Loft, Steffen; Moller, Peter; Nair, Urmila; Nair, Jagadeesan (The Nofer Institute of Occupational Medicine, 2007)
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