Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractToxicological studies have shown increased toxicity of nanoparticles (<100 nm) compared to micrometer particles of the same composition, which has raised concern about the impact on human health from nanoparticles. However, if this is true for a wide range of particles with different chemical composition is not clear. The aim of this study was to compare the toxicity of nano- and micrometer particles of some metal oxides (Fe(2)O(3), Fe(3)O(4), TiO(2) and CuO). The ability of the particles to cause cell death, mitochondrial damage, DNA damage and oxidative DNA lesions were evaluated after exposure of the human cell line A549. This study showed that nanoparticles of CuO were much more toxic compared to CuO micrometer particles. One key mechanism may be the ability of CuO to damage the mitochondria. In contrast, the micrometer particles of TiO(2) caused more DNA damage compared to the nanoparticles, which is likely explained by the crystal structures. The iron oxides showed low toxicity and no clear difference between the different particle sizes. In conclusion, nanoparticles are not always more toxic than micrometer particles, but the high toxicity of CuO nanoparticles shows that the nanolevel gives rise to specific concern.
CitationToxicol. Lett. 2009, 188 (2):112-118
SponsorsThe authors of this paper are members of Stockholm Particle Group (SPG) as well as partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Programme, Priority 5: “Food Quality and Safety” (Contract No. 513943).
- Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes.
- Authors: Karlsson HL, Cronholm P, Gustafsson J, Möller L
- Issue date: 2008 Sep
- Cytotoxicity and genotoxicity of nanosized and microsized titanium dioxide and iron oxide particles in Syrian hamster embryo cells.
- Authors: Guichard Y, Schmit J, Darne C, Gaté L, Goutet M, Rousset D, Rastoix O, Wrobel R, Witschger O, Martin A, Fierro V, Binet S
- Issue date: 2012 Jul
- The toxicity evaluation of nano-trititanate with bactericidal properties in vitro.
- Authors: Pan R, Liu Y, Chen W, Dawson G, Wang X, Li Y, Dong B, Zhu Y
- Issue date: 2012 May
- Comparison of micro- and nanoscale Fe⁺³-containing (Hematite) particles for their toxicological properties in human lung cells in vitro.
- Authors: Bhattacharya K, Hoffmann E, Schins RF, Boertz J, Prantl EM, Alink GM, Byrne HJ, Kuhlbusch TA, Rahman Q, Wiggers H, Schulz C, Dopp E
- Issue date: 2012 Mar
- Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In Vitro.
- Authors: Ivask A, Titma T, Visnapuu M, Vija H, Kakinen A, Sihtmae M, Pokhrel S, Madler L, Heinlaan M, Kisand V, Shimmo R, Kahru A
- Issue date: 2015