Serum levels of organochlorine pesticides in healthy adults from five regions of Spain.
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Authors
Jakszyn, PaulaGoni, Fernando
Etxeandia, Arsenio
Vives, Asuncion
Millan, Esmeralda
Lopez, Raul
Amiano, Pilar
Ardanaz, Eva
Barricarte, Aurelio
Chirlaque, M. Dolores
Dorronsoro, Miren
Larranaga, Nerea
Martinez, Carmen
Navarro, Carmen
Rodriguez, Laudina
Sanchez, M. Jose
Tormo, M. Jose
Gonzalez, Carlos A.
Agudo, Antonio
Issue Date
2009-09
Metadata
Show full item recordAbstract
The aim of this study was to measure of serum levels of p,p'-dichlorodiphenyl trichloroethane (p,p'-DDT), p,p'-dichlorodiphenyl dichlorethylene (p,p'-DDE), beta-hexachlorocyclohexane (beta-HCH), and hexachlorobenzene (HCB) in healthy adults in Spain. Furthermore, we also analyzed these levels according to dietary, other lifestyle factors and anthropometric characteristics. We measured the concentrations of such organochlorine pesticides (OCPs) in serum samples collected during 1992-1996 from 953 subjects aged 35-64 years, they were residents of five Spanish regions, they were randomly selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. OCPs were determined by means of gas chromatography with electron-capture detection (GC-ECD). The most frequent compound found in serum was p,p'-DDE, present in 98% of the samples, followed by HCB and beta-HCH, found in 89% and 77% of samples, respectively, while p,p'-DDT could be measured only in 26% of subjects. The geometric means of serum concentrations (ng/g lipid) were 822 for p,p'-DDE, 167 for beta-HCH, and 379 for HCB. The concentrations of all OCPs were positively associated with age and body mass index, and decreased along the period of blood collection. No association was found between OCPs levels and dietary factors. The concentrations of p,p'-DDE and beta-HCB were higher in Murcia, one of southern regions, most likely associated with intensive past use of pesticides related to agricultural practices, while higher levels of HCB were found in Navarra, located in the north, maybe due to industrial use rather than agricultural application.Citation
Chemosphere 2009, 76 (11):1518-1524Journal
ChemospherePubMed ID
19586652Type
ArticleLanguage
enISSN
1879-1298Sponsors
Some authors (PJ, CAG, AA) are members of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a Network of Excellence of the 6th EU Framework Programme (FP6, FOOD-CT-2005-513 943).ae974a485f413a2113503eed53cd6c53
10.1016/j.chemosphere.2009.05.048
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