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dc.contributor.authorAgudo, Antonio
dc.contributor.authorGoni, Fernando
dc.contributor.authorEtxeandia, Arsenio
dc.contributor.authorVives, Asuncion
dc.contributor.authorMillan, Esmeralda
dc.contributor.authorLopez, Raul
dc.contributor.authorAmiano, Pilar
dc.contributor.authorArdanaz, Eva
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorChirlaque, M. Dolores
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorJakszyn, Paula
dc.contributor.authorLarranaga, Nerea
dc.contributor.authorMartinez, Carmen
dc.contributor.authorNavarro, Carmen
dc.contributor.authorRodriguez, Laudina
dc.contributor.authorSanchez, M. Jose
dc.contributor.authorTormo, M. Jose
dc.contributor.authorGonzalez, Carlos A.
dc.date.accessioned2010-11-05T09:59:33Z
dc.date.available2010-11-05T09:59:33Z
dc.date.issued2009-07
dc.identifier.citationEnviron. Res. 2009, 109 (5):620-628en
dc.identifier.issn1096-0953
dc.identifier.pmid19403125
dc.identifier.doi10.1016/j.envres.2009.03.009
dc.identifier.urihttp://hdl.handle.net/10146/114768
dc.description.abstractBACKGROUND: Polychlorinated biphenyls (PCBs) are persistent compounds that may pose an environmental hazard to humans, food being the main source of exposure for the general population. OBJECTIVE: To measure the serum concentrations of the main PCBs in subjects from the general population in Spain, and to assess potential determinants of such concentrations. METHODS: Serum was obtained from blood samples of 953 subjects aged 35-64 years, residents in five Spanish regions (three from the North and two from the South), randomly selected from the EPIC-Spain cohort. Blood collection took place during 1992-1996 and four PCB congeners (118, 138, 153 and 180) were determined by means of gas chromatography with electron-capture detection (GC-ECD). RESULTS: The concentration of total PCBs was 459 ng/g lipids (or 3.1 microg/l); the corresponding figures for PCB 153 were 186 ng/g lipids and 1.25 microg/l. Men had higher values than women, PCB levels increased with age, and serum concentration of PCBs was higher in northern regions. Body mass index (BMI) was inversely related to PCB concentrations, and fish intake was the dietary factor showing the greatest association with serum PCBs. The pattern described was similar for each congener separately. CONCLUSIONS: We found concentrations similar to those reported in European countries where blood collection was carried during the same period. Regional differences within Spain are not fully explained by anthropometric or dietary factors. The inverse association with BMI suggests that in the mid-1990s there was still ongoing or recent exposure to PCBs in Spain.
dc.description.sponsorshipSome authors (AA, CAG, PJ) are members of The Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS), a Network of Excellence of the 6th EU Framework Programme (FP6,FOOD-CT- 2005-513943).en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4W5M0F8-1&_user=1843694&_coverDate=07%2F31%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=e5646f6452241f9dd392cd31ccfd7071&searchtype=aen
dc.subjectPolychlorinated Biphenylsen
dc.subjectEnvironmental Pollutantsen
dc.subjectEnvironmental Exposureen
dc.subjectHumansen
dc.subjectBlooden
dc.subjectChromatographyen
dc.subject.meshAdult
dc.subject.meshChromatography, Gas
dc.subject.meshDiet
dc.subject.meshEnvironmental Exposure
dc.subject.meshEnvironmental Pollutants
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLife Style
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolychlorinated Biphenyls
dc.subject.meshSpain
dc.titlePolychlorinated biphenyls in Spanish adults: determinants of serum concentrations.en
dc.typeArticleen
dc.identifier.journalEnvironmental Researchen
html.description.abstractBACKGROUND: Polychlorinated biphenyls (PCBs) are persistent compounds that may pose an environmental hazard to humans, food being the main source of exposure for the general population. OBJECTIVE: To measure the serum concentrations of the main PCBs in subjects from the general population in Spain, and to assess potential determinants of such concentrations. METHODS: Serum was obtained from blood samples of 953 subjects aged 35-64 years, residents in five Spanish regions (three from the North and two from the South), randomly selected from the EPIC-Spain cohort. Blood collection took place during 1992-1996 and four PCB congeners (118, 138, 153 and 180) were determined by means of gas chromatography with electron-capture detection (GC-ECD). RESULTS: The concentration of total PCBs was 459 ng/g lipids (or 3.1 microg/l); the corresponding figures for PCB 153 were 186 ng/g lipids and 1.25 microg/l. Men had higher values than women, PCB levels increased with age, and serum concentration of PCBs was higher in northern regions. Body mass index (BMI) was inversely related to PCB concentrations, and fish intake was the dietary factor showing the greatest association with serum PCBs. The pattern described was similar for each congener separately. CONCLUSIONS: We found concentrations similar to those reported in European countries where blood collection was carried during the same period. Regional differences within Spain are not fully explained by anthropometric or dietary factors. The inverse association with BMI suggests that in the mid-1990s there was still ongoing or recent exposure to PCBs in Spain.


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