Polychlorinated biphenyls in Spanish adults: determinants of serum concentrations.
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Authors
Agudo, AntonioGoni, Fernando
Etxeandia, Arsenio
Vives, Asuncion
Millan, Esmeralda
Lopez, Raul
Amiano, Pilar
Ardanaz, Eva
Barricarte, Aurelio
Chirlaque, M. Dolores
Dorronsoro, Miren
Jakszyn, Paula
Larranaga, Nerea
Martinez, Carmen
Navarro, Carmen
Rodriguez, Laudina
Sanchez, M. Jose
Tormo, M. Jose
Gonzalez, Carlos A.
Issue Date
2009-07
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Show full item recordAbstract
BACKGROUND: Polychlorinated biphenyls (PCBs) are persistent compounds that may pose an environmental hazard to humans, food being the main source of exposure for the general population. OBJECTIVE: To measure the serum concentrations of the main PCBs in subjects from the general population in Spain, and to assess potential determinants of such concentrations. METHODS: Serum was obtained from blood samples of 953 subjects aged 35-64 years, residents in five Spanish regions (three from the North and two from the South), randomly selected from the EPIC-Spain cohort. Blood collection took place during 1992-1996 and four PCB congeners (118, 138, 153 and 180) were determined by means of gas chromatography with electron-capture detection (GC-ECD). RESULTS: The concentration of total PCBs was 459 ng/g lipids (or 3.1 microg/l); the corresponding figures for PCB 153 were 186 ng/g lipids and 1.25 microg/l. Men had higher values than women, PCB levels increased with age, and serum concentration of PCBs was higher in northern regions. Body mass index (BMI) was inversely related to PCB concentrations, and fish intake was the dietary factor showing the greatest association with serum PCBs. The pattern described was similar for each congener separately. CONCLUSIONS: We found concentrations similar to those reported in European countries where blood collection was carried during the same period. Regional differences within Spain are not fully explained by anthropometric or dietary factors. The inverse association with BMI suggests that in the mid-1990s there was still ongoing or recent exposure to PCBs in Spain.Citation
Environ. Res. 2009, 109 (5):620-628Journal
Environmental ResearchPubMed ID
19403125Type
ArticleLanguage
enISSN
1096-0953Sponsors
Some authors (AA, CAG, PJ) are members of The Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS), a Network of Excellence of the 6th EU Framework Programme (FP6,FOOD-CT- 2005-513943).ae974a485f413a2113503eed53cd6c53
10.1016/j.envres.2009.03.009
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