Application of OMICS technologies in occupational and environmental health research; current status and projections.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Moore, L. E.
Smith, M. T.
Skibola, C. F.
MetadataShow full item record
AbstractOMICS technologies are relatively new biomarker discovery tools that can be applied to study large sets of biological molecules. Their application in human observational studies (HOS) has become feasible in recent years due to a spectacular increase in the sensitivity, resolution and throughput of OMICS-based assays. Although, the number of OMICS techniques is ever expanding, the five most developed OMICS technologies are genotyping, transcriptomics, epigenomics, proteomics and metabolomics. These techniques have been applied in HOS to various extents. However, their application in occupational environmental health (OEH) research has been limited. Here, we will discuss the opportunities these new techniques provide for OEH research. In addition we will address difficulties and limitations to the interpretation of the data that is generated by OMICS technologies. To illustrate the current status of the application of OMICS in OEH research, we will provide examples of studies that used OMICS technologies to investigate human health effects of two well-known toxicants, benzene and arsenic.
CitationOccup. Environ. Med. 2010, 67 (2):136-143
SponsorsThis work was performed as part of the work package “integrated risk assessment” of the ECNIS Network of Excellence (Environmental Cancer Risk, Nutrition and Individual Susceptibility), operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (FOOD-CT-2005-513943).
- Overview of 'Omics Technologies for Military Occupational Health Surveillance and Medicine.
- Authors: Bradburne C, Graham D, Kingston HM, Brenner R, Pamuku M, Carruth L
- Issue date: 2015 Oct
- "Omics" in pharmaceutical research: overview, applications, challenges, and future perspectives.
- Authors: Yan SK, Liu RH, Jin HZ, Liu XR, Ye J, Shan L, Zhang WD
- Issue date: 2015 Jan
- Using omics approaches to understand pulmonary diseases.
- Authors: Kan M, Shumyatcher M, Himes BE
- Issue date: 2017 Aug 3
- Alzheimer's disease in the omics era.
- Authors: Sancesario GM, Bernardini S
- Issue date: 2018 Sep
- Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium.
- Authors: Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C, Giudice L, Lessey BA, Horcajadas JA, Macklon NS, D'Hooghe T, Campoy C, Fauser BC, Salamonsen LA, Salumets A
- Issue date: 2014 Jan-Feb