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dc.contributor.authorBuckland, Genevieve
dc.contributor.authorAgudo, Antonio
dc.contributor.authorLuján, Leila
dc.contributor.authorJakszyn, Paula
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorPalli, Domenico
dc.contributor.authorBoeing, Heiner
dc.contributor.authorCarneiro, Fátima
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorNesi, Gabriella
dc.contributor.authorManjer, Jonas
dc.contributor.authorRegnér, Sara
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorStenling, Roger
dc.contributor.authorSanchez, María-José
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorNavarro, Carmen
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorAllen, Naomi E.
dc.contributor.authorKey, Timothy J.
dc.contributor.authorBingham, Sheila
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorOvervad, Kim
dc.contributor.authorJensen, Majken
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorPeeters, Petra H. M.
dc.contributor.authorNumans, Mattijs E.
dc.contributor.authorOcké, Marga C.
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorMorois, Sophie
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorLund, Eiliv
dc.contributor.authorCouto, Elisabeth
dc.contributor.authorBoffeta, Paolo
dc.contributor.authorJenab, Mazda
dc.contributor.authorRiboli, Elio
dc.contributor.authorRomaguera, Dora
dc.contributor.authorMouw, Traci
dc.contributor.authorGonzález, Carlos A.
dc.date.accessioned2010-10-19T11:20:19Z
dc.date.available2010-10-19T11:20:19Z
dc.date.issued2010-02
dc.identifier.citationAm. J. Clin. Nutr. 2010, 91 (2):381-390en
dc.identifier.issn1938-3207
dc.identifier.pmid20007304
dc.identifier.doi10.3945/ajcn.2009.28209
dc.identifier.urihttp://hdl.handle.net/10146/113461
dc.description.abstractBACKGROUND: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. OBJECTIVE: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. DESIGN: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. RESULTS: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). CONCLUSION: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC.
dc.description.sponsorshipSome authors are partners of ECNIS, a network of excellence of the EC (6FP contract 513943).en
dc.language.isoenen
dc.relation.urlhttp://www.ajcn.org/cgi/content/abstract/91/2/381en
dc.subjectAdenocarcinomaen
dc.subjectStomach Neoplasmsen
dc.subjectprevention & controlen
dc.subjectDiet, Mediterraneanen
dc.subjectEurope/epidemiologyen
dc.subjectCohort Studiesen
dc.subject.meshAdenocarcinoma
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCohort Studies
dc.subject.meshDiet, Mediterranean
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProportional Hazards Models
dc.subject.meshProspective Studies
dc.subject.meshQuestionnaires
dc.subject.meshStomach Neoplasms
dc.titleAdherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study.en
dc.typeArticleen
dc.identifier.journalThe American Journal of Clinical Nutritionen
html.description.abstractBACKGROUND: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. OBJECTIVE: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. DESIGN: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. RESULTS: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). CONCLUSION: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC.


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