A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Kiemeney, Lambertus A.Sulem, Patrick
Besenbacher, Soren
Vermeulen, Sita H.
Sigurdsson, Asgeir
Thorleifsson, Gudmar
Gudbjartsson, Daniel F.
Stacey, Simon N.
Gudmundsson, Julius
Zanon, Carlo
Kostic, Jelena
Masson, Gisli
Bjarnason, Hjordis
Palsson, Stefan T.
Skarphedinsson, Oskar B.
Gudjonsson, Sigurjon A.
Witjes, J. Alfred
Grotenhuis, Anne J.
Verhaegh, Gerald W.
Bishop, D. Timothy
Sak, Sei Chung
Choudhury, Ananya
Elliott, Faye
Barrett, Jennifer H.
Hurst, Carolyn D.
de Verdier, Petra J.
Ryk, Charlotta
Rudnai, Peter
Gurzau, Eugene
Koppova, Kvetoslava
Vineis, Paolo
Polidoro, Silvia
Guarrera, Simonetta
Sacerdote, Carlotta
Campagna, Marcello
Placidi, Donatella
Arici, Cecilia
Zeegers, Maurice P.
Kellen, Eliane
Gutierrez, Berta Saez
Sanz-Velez, José I.
Sanchez-Zalabardo, Manuel
Valdivia, Gabriel
Garcia-Prats, Maria D.
Hengstler, Jan G.
Blaszkewicz, Meinolf
Dietrich, Holger
Ophoff, Roel A.
van den Berg, Leonard H.
Alexiusdottir, Kristin
Kristjansson, Kristleifur
Geirsson, Gudmundur
Nikulasson, Sigfus
Petursdottir, Vigdis
Kong, Augustine
Thorgeirsson, Thorgeir
Mungan, N. Aydin
Lindblom, Annika
van Es, Michael A.
Porru, Stefano
Buntinx, Frank
Golka, Klaus
Mayordomo, José I.
Kumar, Rajiv
Matullo, Giuseppe
Steineck, Gunnar
Kiltie, Anne E.
Aben, Katja K.H.
Jonsson, Eirikur
Thorsteinsdottir, Unnur
Knowles, Margaret A.
Rafnar, Thorunn
Stefansson, Kari
Issue Date
2010-05
Metadata
Show full item recordAbstract
Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set and tested the top 20 markers from the combined analysis in several European case-control sample sets, with a total of 4,739 cases and 45,549 controls. The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC. Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low-grade stage Ta tumors. The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC.Citation
Nat. Genet. 2010, 42 (5):415-419Journal
Nature GeneticsDOI
10.1038/ng.558PubMed ID
20348956Additional Links
http://www.nature.com/ng/journal/v42/n5/full/ng.558.htmlType
ArticleLanguage
enISSN
1546-1718Sponsors
The Torino Bladder Cancer Case Control Study was supported by a grant to ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union Sixth Framework Program, Priority 5: ‘Food Quality and Safety’ (Contract No. 513943), and by grants of the Compagnia di San Paolo, of the Italian Association for Cancer Research and of the Piedmont Region Progetti de Ricerca Sanitaria Finalizzata, Italy. The Belgian case-control study on bladder cancer risk was supported by a grant of the Flemish government, the government of the Belgian province of Limburg and the Limburg Cancer Fund.ae974a485f413a2113503eed53cd6c53
10.1038/ng.558
Scopus Count
Collections
Related articles
- Chromosome 4p16.3 variant modify bladder cancer risk in a Chinese population.
- Authors: Wang M, Chu H, Yan F, Qin C, Li P, Yuan L, Yin C, Xu J, Zhang Z
- Issue date: 2011 Jun
- Genetic polymorphisms on 8q24.1 and 4p16.3 are not linked with urothelial carcinoma of the bladder in contrast to their association with aggressive upper urinary tract tumours.
- Authors: Yates DR, Rouprêt M, Drouin SJ, Audouin M, Cancel-Tassin G, Comperat E, Bitker MO, Cussenot O
- Issue date: 2013 Feb
- Plasma 25-hydroxyvitamin D(3) and bladder cancer risk according to tumor stage and FGFR3 status: a mechanism-based epidemiological study.
- Authors: Amaral AF, Méndez-Pertuz M, Muñoz A, Silverman DT, Allory Y, Kogevinas M, Lloreta J, Rothman N, Carrato A, Rivas del Fresno M, Real FX, Malats N, Spanish Bladder Cancer/EPICURO Study investigators.
- Issue date: 2012 Dec 19
- Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
- Authors: Allory Y, Beukers W, Sagrera A, Flández M, Marqués M, Márquez M, van der Keur KA, Dyrskjot L, Lurkin I, Vermeij M, Carrato A, Lloreta J, Lorente JA, Carrillo-de Santa Pau E, Masius RG, Kogevinas M, Steyerberg EW, van Tilborg AA, Abas C, Orntoft TF, Zuiverloon TC, Malats N, Zwarthoff EC, Real FX
- Issue date: 2014 Feb
- TERT promoter mutations and TERT mRNA but not FGFR3 mutations are urinary biomarkers in Han Chinese patients with urothelial bladder cancer.
- Authors: Wang K, Liu T, Liu C, Meng Y, Yuan X, Liu L, Ge N, Liu J, Wang C, Ren H, Yan K, Hu S, Xu Z, Fan Y, Xu D
- Issue date: 2015 Mar