Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood-Lack of Association with Tobacco Smoke Exposure.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618253
Title:
Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood-Lack of Association with Tobacco Smoke Exposure.
Authors:
Gromadzinska, Jolanta; Polanska, Kinga; Kozlowska, Lucyna; Mikolajewska, Karolina; Stelmach, Iwona; Jerzyńska, Joanna; Stelmach, Włodzimierz; Grzesiak, Mariusz; Hanke, Wojciech; Wasowicz, Wojciech
Abstract:
Epidemiological studies have suggested an association between maternal antioxidant levels during pregnancy and development of allergic diseases in their offspring. The aim of the study was to determine plasma vitamins A and E concentration in the 1st trimester of pregnancy, at delivery and in cord blood and to search for a relationship with allergy in up to 2-year-old children who were prenatally exposed or not exposed to tobacco smoke. The study participants included 252 mother-child pairs from Polish Mother and Child Cohort. Vitamin concentrations were measured using the HPLC-UV method, smoking status—as saliva cotinine level using the HPLC-MS/MS technique. Children’s health status was assessed using a questionnaire and pediatricians/allergists examination. Cord plasma vitamin concentrations were significantly lower than their levels in maternal plasma in the 1sttrimester and at delivery (p < 0.001). Significantly higher concentrations of vitamin E have been shown to occur during the 1st trimester of pregnancy in plasma of the women who have actively/passively smoked cigarettes compared to the non-smokers (p < 0.02). Multivariate analysis with inclusion of a variety of confounding factors have not indicated any statistically significant associations between β-carotene, vitamins A and E and the risk of food allergy, atopic dermatitis and wheezing in their children up to 2 years of age. The interaction between smoking during pregnancy and vitamins levels on the risk of allergy was not statistically significant (p < 0.4). The relationship between plasma concentration of vitamins A and E, and the risk of allergy in their young children has not been demonstrated.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Int J Environ Res Public Health 2018, 15 (6) art: E1245.
Journal:
International Journal of Environmental Research and Public Health
Issue Date:
2018
URI:
http://hdl.handle.net/10146/618253
DOI:
10.3390/ijerph15061245
PubMed ID:
29895780
Additional Links:
https://www.mdpi.com/1660-4601/15/6/1245
Type:
Article
Language:
en
ISSN:
1660-4601
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorGromadzinska, Jolantaen
dc.contributor.authorPolanska, Kingaen
dc.contributor.authorKozlowska, Lucynaen
dc.contributor.authorMikolajewska, Karolinaen
dc.contributor.authorStelmach, Iwonaen
dc.contributor.authorJerzyńska, Joannaen
dc.contributor.authorStelmach, Włodzimierzen
dc.contributor.authorGrzesiak, Mariuszen
dc.contributor.authorHanke, Wojciechen
dc.contributor.authorWasowicz, Wojciechen
dc.date.accessioned2018-12-05T10:08:23Z-
dc.date.available2018-12-05T10:08:23Z-
dc.date.issued2018-
dc.identifier.citationInt J Environ Res Public Health 2018, 15 (6) art: E1245.en
dc.identifier.issn1660-4601-
dc.identifier.pmid29895780-
dc.identifier.doi10.3390/ijerph15061245-
dc.identifier.urihttp://hdl.handle.net/10146/618253-
dc.description.abstractEpidemiological studies have suggested an association between maternal antioxidant levels during pregnancy and development of allergic diseases in their offspring. The aim of the study was to determine plasma vitamins A and E concentration in the 1st trimester of pregnancy, at delivery and in cord blood and to search for a relationship with allergy in up to 2-year-old children who were prenatally exposed or not exposed to tobacco smoke. The study participants included 252 mother-child pairs from Polish Mother and Child Cohort. Vitamin concentrations were measured using the HPLC-UV method, smoking status—as saliva cotinine level using the HPLC-MS/MS technique. Children’s health status was assessed using a questionnaire and pediatricians/allergists examination. Cord plasma vitamin concentrations were significantly lower than their levels in maternal plasma in the 1sttrimester and at delivery (p < 0.001). Significantly higher concentrations of vitamin E have been shown to occur during the 1st trimester of pregnancy in plasma of the women who have actively/passively smoked cigarettes compared to the non-smokers (p < 0.02). Multivariate analysis with inclusion of a variety of confounding factors have not indicated any statistically significant associations between β-carotene, vitamins A and E and the risk of food allergy, atopic dermatitis and wheezing in their children up to 2 years of age. The interaction between smoking during pregnancy and vitamins levels on the risk of allergy was not statistically significant (p < 0.4). The relationship between plasma concentration of vitamins A and E, and the risk of allergy in their young children has not been demonstrated.en
dc.language.isoenen
dc.relation.urlhttps://www.mdpi.com/1660-4601/15/6/1245en
dc.rightsArchived with thanks to International journal of environmental research and public healthen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdermalen
dc.subjectrespiratory and food allergyen
dc.subjectchildrenen
dc.subjectpregnancyen
dc.subjectsmokingen
dc.subjectvitamins A, Een
dc.subjectβ-caroteneen
dc.titleVitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood-Lack of Association with Tobacco Smoke Exposure.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalInternational Journal of Environmental Research and Public Healthen

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