Urinary Bisphenol A Levels and Male Fertility.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618252
Title:
Urinary Bisphenol A Levels and Male Fertility.
Authors:
Radwan, Michał; Wielgomas, Bartosz; Dziewirska, Emila; Radwan, Paweł; Kałużny, Paweł; Klimowska, Anna; Hanke, Wojciech; Jurewicz, Joanna
Abstract:
Bisphenol A (BPA) is a high-production volume industrial chemical found in many consumer products. BPA is a suspected potent endocrine disruptor, with endocrine-disrupting properties demonstrated in animal studies. Few human studies have examined bisphenol A exposure in relation to male fertility and, results are divergent. The aim of the study is to examine the associations between urinary BPA concentration and male fertility. Bisphenol A urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men under 45 years of age with normal sperm concentration (⩾15 mln/ml) recruited from a male reproductive health clinic. Participants were interviewed and provided a semen sample. BPA was detected in 98.10% of urine samples, with a median concentration of 1.87 µg/l (1.63 µg/ g creatinine). A multiple linear regression analysis identified a positive association between the urinary concentrations of bisphenol A 25th-50th percentile and total sperm sex chromosome disomy ( p = .004). Also when modeled as continuous variable urinary BPA concentration increased total sperm sex chromosome disomy ( p = .01). Urinary concentration of BPA also increase the percentage of immature sperm (HDS) ( p = .018) and decrease motility ( p = .03). The study provides evidence that exposure to BPA is associated with poorer semen quality. Future studies are needed to confirm these findings.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Am J Mens Health 2018, 12 (6):2144-2151
Journal:
American Journal of Men's Health
Issue Date:
Nov-2018
URI:
http://hdl.handle.net/10146/618252
DOI:
10.1177/1557988318799163
PubMed ID:
30261816
Additional Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199454/
Type:
Article
Language:
en
ISSN:
1557-9891
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorRadwan, Michałen
dc.contributor.authorWielgomas, Bartoszen
dc.contributor.authorDziewirska, Emilaen
dc.contributor.authorRadwan, Pawełen
dc.contributor.authorKałużny, Pawełen
dc.contributor.authorKlimowska, Annaen
dc.contributor.authorHanke, Wojciechen
dc.contributor.authorJurewicz, Joannaen
dc.date.accessioned2018-12-05T10:04:28Z-
dc.date.available2018-12-05T10:04:28Z-
dc.date.issued2018-11-
dc.identifier.citationAm J Mens Health 2018, 12 (6):2144-2151en
dc.identifier.issn1557-9891-
dc.identifier.pmid30261816-
dc.identifier.doi10.1177/1557988318799163-
dc.identifier.urihttp://hdl.handle.net/10146/618252-
dc.description.abstractBisphenol A (BPA) is a high-production volume industrial chemical found in many consumer products. BPA is a suspected potent endocrine disruptor, with endocrine-disrupting properties demonstrated in animal studies. Few human studies have examined bisphenol A exposure in relation to male fertility and, results are divergent. The aim of the study is to examine the associations between urinary BPA concentration and male fertility. Bisphenol A urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men under 45 years of age with normal sperm concentration (⩾15 mln/ml) recruited from a male reproductive health clinic. Participants were interviewed and provided a semen sample. BPA was detected in 98.10% of urine samples, with a median concentration of 1.87 µg/l (1.63 µg/ g creatinine). A multiple linear regression analysis identified a positive association between the urinary concentrations of bisphenol A 25th-50th percentile and total sperm sex chromosome disomy ( p = .004). Also when modeled as continuous variable urinary BPA concentration increased total sperm sex chromosome disomy ( p = .01). Urinary concentration of BPA also increase the percentage of immature sperm (HDS) ( p = .018) and decrease motility ( p = .03). The study provides evidence that exposure to BPA is associated with poorer semen quality. Future studies are needed to confirm these findings.en
dc.language.isoenen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199454/en
dc.rightsArchived with thanks to American journal of men's healthen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectenvironmental exposure to bisphenol Aen
dc.subjectsemen qualityen
dc.subjectDNA fragmentationen
dc.subjectsperm aneuploidyen
dc.titleUrinary Bisphenol A Levels and Male Fertility.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalAmerican Journal of Men's Healthen

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