The effect of repeated cadmium oral exposure on the level of sex hormones, estrous cyclicity, and endometrium morphometry in female rats.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618248
Title:
The effect of repeated cadmium oral exposure on the level of sex hormones, estrous cyclicity, and endometrium morphometry in female rats.
Authors:
Nasiadek, Marzenna; Danilewicz, Marian; Sitarek, Krystyna; Świątkowska, Ewa; Daragó, Adam; Stragierowicz, Joanna; Kilanowicz, Anna
Abstract:
Cadmium (Cd) is regarded as a potential endocrine disruptor. However, the exact mechanism by which this metal may interfere with the reproductive system has not yet been elucidated. The present study aimed to investigate the effect of subacute Cd oral administration at daily doses of 0.09, 1.8, and 4.5 mgCd/kg b.w. and the impact of Cd on sex hormones (estradiol (E2) and progesterone (P)) in the plasma and uterus, as well as on estrous cyclicity and histopathological changes in uterine and ovary in female rats after terminating the exposure and after a prolonged observation period (3 months). Moreover, Cd bioaccumulation in the uterine and brain tissue of rats was analyzed. The study revealed that oral Cd exposure induced changes in the plasma levels of steroid hormones: decrease in E2 and increase in P after the highest dose of Cd. Probably, for the first time, it was evidenced that circulation sex hormone disturbances in Cd-exposed rats caused irregular estrous cycle, persisting for 3 months after exposure termination; no alterations in these hormone levels in uterine tissue were noted. Cd did not induce estradiol-like hyperplasia of endometrium, but resulted in endometrial edema irrespective of the dose, and caused damage of the ovaries after the highest dose. In summary, subacute oral exposure of female rats to Cd may lead to long-term disturbances in reproductive system.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Environ Sci Pollut Res Int 2018, 25 (28):28025-28038
Journal:
Environmental science and pollution research international
Issue Date:
Oct-2018
URI:
http://hdl.handle.net/10146/618248
DOI:
10.1007/s11356-018-2821-5
PubMed ID:
30066076
Additional Links:
https://link.springer.com/article/10.1007%2Fs11356-018-2821-5
Type:
Article
Language:
en
ISSN:
1614-7499
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorNasiadek, Marzennaen
dc.contributor.authorDanilewicz, Marianen
dc.contributor.authorSitarek, Krystynaen
dc.contributor.authorŚwiątkowska, Ewaen
dc.contributor.authorDaragó, Adamen
dc.contributor.authorStragierowicz, Joannaen
dc.contributor.authorKilanowicz, Annaen
dc.date.accessioned2018-12-05T09:43:27Z-
dc.date.available2018-12-05T09:43:27Z-
dc.date.issued2018-10-
dc.identifier.citationEnviron Sci Pollut Res Int 2018, 25 (28):28025-28038en
dc.identifier.issn1614-7499-
dc.identifier.pmid30066076-
dc.identifier.doi10.1007/s11356-018-2821-5-
dc.identifier.urihttp://hdl.handle.net/10146/618248-
dc.description.abstractCadmium (Cd) is regarded as a potential endocrine disruptor. However, the exact mechanism by which this metal may interfere with the reproductive system has not yet been elucidated. The present study aimed to investigate the effect of subacute Cd oral administration at daily doses of 0.09, 1.8, and 4.5 mgCd/kg b.w. and the impact of Cd on sex hormones (estradiol (E2) and progesterone (P)) in the plasma and uterus, as well as on estrous cyclicity and histopathological changes in uterine and ovary in female rats after terminating the exposure and after a prolonged observation period (3 months). Moreover, Cd bioaccumulation in the uterine and brain tissue of rats was analyzed. The study revealed that oral Cd exposure induced changes in the plasma levels of steroid hormones: decrease in E2 and increase in P after the highest dose of Cd. Probably, for the first time, it was evidenced that circulation sex hormone disturbances in Cd-exposed rats caused irregular estrous cycle, persisting for 3 months after exposure termination; no alterations in these hormone levels in uterine tissue were noted. Cd did not induce estradiol-like hyperplasia of endometrium, but resulted in endometrial edema irrespective of the dose, and caused damage of the ovaries after the highest dose. In summary, subacute oral exposure of female rats to Cd may lead to long-term disturbances in reproductive system.en
dc.language.isoenen
dc.relation.urlhttps://link.springer.com/article/10.1007%2Fs11356-018-2821-5en
dc.rightsArchived with thanks to Environmental science and pollution research internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcadmiumen
dc.subjectEstradiolen
dc.subjectEstrous cycleen
dc.subjectOvariesen
dc.subjectProgesteroneen
dc.subjectraten
dc.subjectUterusen
dc.titleThe effect of repeated cadmium oral exposure on the level of sex hormones, estrous cyclicity, and endometrium morphometry in female rats.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalEnvironmental science and pollution research internationalen
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