Sleep quality and methylation status of selected tumor suppressor genes among nurses and midwives.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618244
Title:
Sleep quality and methylation status of selected tumor suppressor genes among nurses and midwives.
Authors:
Bukowska-Damska, Agnieszka; Reszka, Edyta; Kaluzny, Pawel; Wieczorek, Edyta; Przybek, Monika; Zienolddiny, Shanbeh; Peplonska, Beata
Abstract:
Chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited reports suggest also epigenetic effects, such as changes in DNA methylation profiles. The study aims to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of selected tumor suppressor genes. A cross-sectional study was conducted on 710 nurses and midwives aged 40-60 years. Data from interviews regarding sleep habits and potential confounders were used. The methylation status of tumor suppressor genes was determined via qMSP reactions using DNA samples derived from leucocytes. No significant findings were observed in the total study population or in the two subgroups of women stratified by the current system of work. A borderline significance association was observed between a shorter duration of sleep and an increased methylation level in CDKN2A among day working nurses and midwives. Further studies are warranted to explore this under-investigated topic.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Chronobiol. Int. 2018, 35 (1):122-131
Journal:
Chronobiology International
Issue Date:
2018
URI:
http://hdl.handle.net/10146/618244
DOI:
10.1080/07420528.2017.1376219
PubMed ID:
29144154
Additional Links:
https://www.tandfonline.com/doi/abs/10.1080/07420528.2017.1376219?journalCode=icbi20
Type:
Article
Language:
en
ISSN:
1525-6073
Sponsors:
This project was supported by the Norway Grants, under the Polish-Norwegian Research Programme (Grant no. PNRF – 243 – AI – 1/07 and Pol-Nor/196940/22/2013-clockshift).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorBukowska-Damska, Agnieszkaen
dc.contributor.authorReszka, Edytaen
dc.contributor.authorKaluzny, Pawelen
dc.contributor.authorWieczorek, Edytaen
dc.contributor.authorPrzybek, Monikaen
dc.contributor.authorZienolddiny, Shanbehen
dc.contributor.authorPeplonska, Beataen
dc.date.accessioned2018-12-05T09:15:50Z-
dc.date.available2018-12-05T09:15:50Z-
dc.date.issued2018-
dc.identifier.citationChronobiol. Int. 2018, 35 (1):122-131en
dc.identifier.issn1525-6073-
dc.identifier.pmid29144154-
dc.identifier.doi10.1080/07420528.2017.1376219-
dc.identifier.urihttp://hdl.handle.net/10146/618244-
dc.description.abstractChronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited reports suggest also epigenetic effects, such as changes in DNA methylation profiles. The study aims to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of selected tumor suppressor genes. A cross-sectional study was conducted on 710 nurses and midwives aged 40-60 years. Data from interviews regarding sleep habits and potential confounders were used. The methylation status of tumor suppressor genes was determined via qMSP reactions using DNA samples derived from leucocytes. No significant findings were observed in the total study population or in the two subgroups of women stratified by the current system of work. A borderline significance association was observed between a shorter duration of sleep and an increased methylation level in CDKN2A among day working nurses and midwives. Further studies are warranted to explore this under-investigated topic.en
dc.description.sponsorshipThis project was supported by the Norway Grants, under the Polish-Norwegian Research Programme (Grant no. PNRF – 243 – AI – 1/07 and Pol-Nor/196940/22/2013-clockshift).en
dc.language.isoenen
dc.relation.urlhttps://www.tandfonline.com/doi/abs/10.1080/07420528.2017.1376219?journalCode=icbi20en
dc.rightsArchived with thanks to Chronobiology internationalen
dc.subjectDNA methylationen
dc.subjectnurses and midwivesen
dc.subjectshiftworken
dc.subjecttumor suppressor genesen
dc.titleSleep quality and methylation status of selected tumor suppressor genes among nurses and midwives.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalChronobiology Internationalen

Related articles on PubMed

All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.