Revision of reciprocal action of mercury and selenium.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618243
Title:
Revision of reciprocal action of mercury and selenium.
Authors:
Kuraś, Renata; Janasik, Beata; Wąsowicz, Wojciech; Stanisławska, Magdalena
Abstract:
Diverse forms of mercury (Hg) have various effects on animals and humans because of a variety of routes of administration. Inorganic mercury (iHg) binds to thiol groups of proteins and enzymes in one's body or is methylated by microorganisms. Organic form of Hg, contrary to the iHg, is more stable but may be demethylated to Hg<sup>2+</sup> in the tissue of intestinal flora. Selenium (Se) also occurs in a variety of chemical forms in one's body but both of these elements behave very differently from one another. Mercury binding to selenide or Se-containing ligands is a primary molecular mechanism that reduces toxicity of Hg. Complexes formed in such a way are irreversible, and thus, biologically inactive. Se deficiency in a human body may impair normal synthesis of selenoproteins and its expression because expression of mRNA may be potentially regulated by the Se status. This paper provides a comprehensive review concerning Hg-Se reciprocal action as a potential mechanism of protective action of Se against Hg toxicity as well as a potential detoxification mechanism. Although interactions between Hg-Se have been presented in numerous studies concerning animals and humans, we have focused mainly on animal models so as to understand molecular mechanisms responsible for antagonism better. The review also investigates what conclusions have been drawn by researchers with respect to the chemical species of Se and Hg (and their relationship) in biological systems as well as genetic variations and expression and/or activity of selenoproteins related to the thioredoxin (thioredoxin Trx/TrxR) system and glutathione metabolism. Int J Occup Med Environ Health 2018;31(5):575-592.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Int J Occup Med Environ Health 2018, 31 (5):575-592
Journal:
International Journal of Occupational Medicine and Environmental Health
Issue Date:
23-Oct-2018
URI:
http://hdl.handle.net/10146/618243
DOI:
10.13075/ijomeh.1896.01278
PubMed ID:
29911664
Additional Links:
http://ijomeh.eu/Revision-of-the-reciprocal-action-of-mercury-and-selenium,84798,0,2.html
Type:
Article
Language:
en
ISSN:
1896-494X
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorKuraś, Renataen
dc.contributor.authorJanasik, Beataen
dc.contributor.authorWąsowicz, Wojciechen
dc.contributor.authorStanisławska, Magdalenaen
dc.date.accessioned2018-12-05T09:11:40Z-
dc.date.available2018-12-05T09:11:40Z-
dc.date.issued2018-10-23-
dc.identifier.citationInt J Occup Med Environ Health 2018, 31 (5):575-592en
dc.identifier.issn1896-494X-
dc.identifier.pmid29911664-
dc.identifier.doi10.13075/ijomeh.1896.01278-
dc.identifier.urihttp://hdl.handle.net/10146/618243-
dc.description.abstractDiverse forms of mercury (Hg) have various effects on animals and humans because of a variety of routes of administration. Inorganic mercury (iHg) binds to thiol groups of proteins and enzymes in one's body or is methylated by microorganisms. Organic form of Hg, contrary to the iHg, is more stable but may be demethylated to Hg<sup>2+</sup> in the tissue of intestinal flora. Selenium (Se) also occurs in a variety of chemical forms in one's body but both of these elements behave very differently from one another. Mercury binding to selenide or Se-containing ligands is a primary molecular mechanism that reduces toxicity of Hg. Complexes formed in such a way are irreversible, and thus, biologically inactive. Se deficiency in a human body may impair normal synthesis of selenoproteins and its expression because expression of mRNA may be potentially regulated by the Se status. This paper provides a comprehensive review concerning Hg-Se reciprocal action as a potential mechanism of protective action of Se against Hg toxicity as well as a potential detoxification mechanism. Although interactions between Hg-Se have been presented in numerous studies concerning animals and humans, we have focused mainly on animal models so as to understand molecular mechanisms responsible for antagonism better. The review also investigates what conclusions have been drawn by researchers with respect to the chemical species of Se and Hg (and their relationship) in biological systems as well as genetic variations and expression and/or activity of selenoproteins related to the thioredoxin (thioredoxin Trx/TrxR) system and glutathione metabolism. Int J Occup Med Environ Health 2018;31(5):575-592.en
dc.language.isoenen
dc.relation.urlhttp://ijomeh.eu/Revision-of-the-reciprocal-action-of-mercury-and-selenium,84798,0,2.htmlen
dc.rightsArchived with thanks to International journal of occupational medicine and environmental healthen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectantagonismen
dc.subjectgene expressionen
dc.subjectinteractionen
dc.subjectmercuryen
dc.subjectpolymorphismen
dc.subjectseleniumen
dc.titleRevision of reciprocal action of mercury and selenium.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalInternational Journal of Occupational Medicine and Environmental Healthen

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