mRNA, microRNA and lncRNA as novel bladder tumor markers.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618235
Title:
mRNA, microRNA and lncRNA as novel bladder tumor markers.
Authors:
Wieczorek, Edyta; Reszka, Edyta
Abstract:
Early detection of bladder cancer (BC) is essential for improvement of the patient's prognosis and general survival rates. Current diagnostic methods are still limited, so new specific and cost-effective biomarkers are emerging as the noninvasive tools in treatment decisions in recurrent BC. Gene expression and epigenetic profile can be analysed using quantitative real-time-PCR (qRT-PCR) method in urine, blood and tissue. This review provides an update of recent findings on BC molecular profile as novel markers in diagnosis and prognosis of bladder tumors. We describe mRNA-, microRNA- and lncRNA-based biomarkers involved in the BC detection, diagnosis, prediction of recurrence and monitoring after treatment.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Clin. Chim. Acta 2018, 477:141-153
Journal:
Clinica Chimica Acta
Issue Date:
Feb-2018
URI:
http://hdl.handle.net/10146/618235
DOI:
10.1016/j.cca.2017.12.009
PubMed ID:
29224950
Additional Links:
https://www.sciencedirect.com/science/article/pii/S0009898117304941?via%3Dihub
Type:
Article
Language:
en
ISSN:
1873-3492
Sponsors:
This research was supported by Internal Grant IMP (14.2 and 1.39), and by the National Science Centre, Poland (2012/05/B/NZ5/01406 and 2016/23/N/NZ5/01408).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorWieczorek, Edytaen
dc.contributor.authorReszka, Edytaen
dc.date.accessioned2018-12-04T09:54:40Z-
dc.date.available2018-12-04T09:54:40Z-
dc.date.issued2018-02-
dc.identifier.citationClin. Chim. Acta 2018, 477:141-153en
dc.identifier.issn1873-3492-
dc.identifier.pmid29224950-
dc.identifier.doi10.1016/j.cca.2017.12.009-
dc.identifier.urihttp://hdl.handle.net/10146/618235-
dc.description.abstractEarly detection of bladder cancer (BC) is essential for improvement of the patient's prognosis and general survival rates. Current diagnostic methods are still limited, so new specific and cost-effective biomarkers are emerging as the noninvasive tools in treatment decisions in recurrent BC. Gene expression and epigenetic profile can be analysed using quantitative real-time-PCR (qRT-PCR) method in urine, blood and tissue. This review provides an update of recent findings on BC molecular profile as novel markers in diagnosis and prognosis of bladder tumors. We describe mRNA-, microRNA- and lncRNA-based biomarkers involved in the BC detection, diagnosis, prediction of recurrence and monitoring after treatment.en
dc.description.sponsorshipThis research was supported by Internal Grant IMP (14.2 and 1.39), and by the National Science Centre, Poland (2012/05/B/NZ5/01406 and 2016/23/N/NZ5/01408).en
dc.language.isoenen
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0009898117304941?via%3Dihuben
dc.rightsArchived with thanks to Clinica chimica acta; international journal of clinical chemistryen
dc.subjectbladder canceren
dc.subjectMolecular markersen
dc.subjectlncRNAen
dc.subjectmRNAen
dc.subjectmicroRNAen
dc.subjectqRT-PCRen
dc.subject.meshBiomarkers, Tumor-
dc.subject.meshHumans-
dc.subject.meshMicroRNAs-
dc.subject.meshRNA, Long Noncoding-
dc.subject.meshRNA, Messenger-
dc.subject.meshReal-Time Polymerase Chain Reaction-
dc.subject.meshUrinary Bladder Neoplasms-
dc.titlemRNA, microRNA and lncRNA as novel bladder tumor markers.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalClinica Chimica Actaen

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