Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

2.50
Hdl Handle:
http://hdl.handle.net/10146/618230
Title:
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Authors:
Ji, Xuemei; Bossé, Yohan ( 0000-0002-3067-3711 ) ; Landi, Maria Teresa; Gui, Jiang; Xiao, Xiangjun; Qian, David; Joubert, Philippe; Lamontagne, Maxime; Li, Yafang; Gorlov, Ivan; de Biasi, Mariella; Han, Younghun; Gorlova, Olga; Hung, Rayjean J.; Wu, Xifeng ( 0000-0001-5174-3769 ) ; McKay, James; Zong, Xuchen; Carreras-Torres, Robert; Christiani, David C.; Caporaso, Neil; Johansson, Mattias; Liu, Geoffrey; Bojesen, Stig E. ( 0000-0002-4061-4133 ) ; Le Marchand, Loic; Albanes, Demetrios; Bickeböller, Heike; Aldrich, Melinda C.; Bush, William S.; Tardon, Adonina; Rennert, Gad ( 0000-0002-8512-068X ) ; Chen, Chu; Teare, M. Dawn; Field, John K.; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B. ( 0000-0003-3241-3216 ) ; Andrew, Angeline S.; Shen, Hongbing; Hong, Yun-Chul; Yuan, Jian-Min; Bertazzi, Pier A. ( 0000-0003-3475-2449 ) ; Pesatori, Angela C. ( 0000-0002-0261-3252 ) ; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha; Johansen, Jakob S.; Mellemgaard, Anders; Saliba, Walid; Haiman, Christopher; Wilkens, Lynne; Fernandez-Somoano, Ana ( 0000-0002-8135-9079 ) ; Fernandez-Tardon, Guillermo; van der Heijden, Erik H. F. M. ( 0000-0003-3596-518X ) ; Kim, Jin Hee ( 0000-0003-1204-7079 ) ; Dai, Juncheng; Hu, Zhibin; Davies, Michael P. A.; Marcus, Michael W.; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C. ( 0000-0002-2350-0417 ) ; Overvad, Kim; Trichopoulou, Antonia; Tumino, Rosario; Doherty, Jennifer; Goodman, Gary E.; Cox, Angela ( 0000-0002-5138-1099 ) ; Taylor, Fiona; Woll, Penella; Brüske, Irene; Manz, Judith; Muley, Thomas; Risch, Angela ( 0000-0002-8026-5505 ) ; Rosenberger, Albert; Grankvist, Kjell ( 0000-0003-4289-2097 ) ; Johansson, Mikael; Shepherd, Frances; Tsao, Ming-Sound; Arnold, Susanne M. ( 0000-0001-6542-9551 ) ; Haura, Eric B.; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolanta; Mukeria, Anush; Ognjanovic, Simona; Orlowski, Tadeusz M.; Scelo, Ghislaine; Swiatkowska, Beata; Zaridze, David; Bakke, Per; Skaug, Vidar; Zienolddiny, Shanbeh; Duell, Eric J.; Butler, Lesley M.; Koh, Woon-Puay; Gao, Yu-Tang; Houlston, Richard ( 0000-0002-5268-0242 ) ; McLaughlin, John; Stevens, Victoria; Nickle, David C.; Obeidat, Ma’en ( 0000-0002-5443-2752 ) ; Timens, Wim ( 0000-0002-4146-6363 ) ; Zhu, Bin; Song, Lei; Artigas, María Soler; Tobin, Martin D. ( 0000-0002-3596-7874 ) ; Wain, Louise V.; Gu, Fangyi; Byun, Jinyoung; Kamal, Ahsan; Zhu, Dakai; Tyndale, Rachel F.; Wei, Wei-Qi; Chanock, Stephen; Brennan, Paul ( 0000-0002-0518-8714 ) ; Amos, Christopher I. ( 0000-0002-8540-7023 )
Abstract:
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Nature Communications2018, 9 (1):3221
Journal:
Nature Communications
Issue Date:
13-Aug-2018
URI:
http://hdl.handle.net/10146/618230
DOI:
10.1038/s41467-018-05074-y
Additional Links:
http://www.nature.com/articles/s41467-018-05074-y
Type:
Article
Language:
en
ISSN:
2041-1723
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorJi, Xuemeien
dc.contributor.authorBossé, Yohanen
dc.contributor.authorLandi, Maria Teresaen
dc.contributor.authorGui, Jiangen
dc.contributor.authorXiao, Xiangjunen
dc.contributor.authorQian, Daviden
dc.contributor.authorJoubert, Philippeen
dc.contributor.authorLamontagne, Maximeen
dc.contributor.authorLi, Yafangen
dc.contributor.authorGorlov, Ivanen
dc.contributor.authorde Biasi, Mariellaen
dc.contributor.authorHan, Younghunen
dc.contributor.authorGorlova, Olgaen
dc.contributor.authorHung, Rayjean J.en
dc.contributor.authorWu, Xifengen
dc.contributor.authorMcKay, Jamesen
dc.contributor.authorZong, Xuchenen
dc.contributor.authorCarreras-Torres, Roberten
dc.contributor.authorChristiani, David C.en
dc.contributor.authorCaporaso, Neilen
dc.contributor.authorJohansson, Mattiasen
dc.contributor.authorLiu, Geoffreyen
dc.contributor.authorBojesen, Stig E.en
dc.contributor.authorLe Marchand, Loicen
dc.contributor.authorAlbanes, Demetriosen
dc.contributor.authorBickeböller, Heikeen
dc.contributor.authorAldrich, Melinda C.en
dc.contributor.authorBush, William S.en
dc.contributor.authorTardon, Adoninaen
dc.contributor.authorRennert, Gaden
dc.contributor.authorChen, Chuen
dc.contributor.authorTeare, M. Dawnen
dc.contributor.authorField, John K.en
dc.contributor.authorKiemeney, Lambertus A.en
dc.contributor.authorLazarus, Philipen
dc.contributor.authorHaugen, Aageen
dc.contributor.authorLam, Stephenen
dc.contributor.authorSchabath, Matthew B.en
dc.contributor.authorAndrew, Angeline S.en
dc.contributor.authorShen, Hongbingen
dc.contributor.authorHong, Yun-Chulen
dc.contributor.authorYuan, Jian-Minen
dc.contributor.authorBertazzi, Pier A.en
dc.contributor.authorPesatori, Angela C.en
dc.contributor.authorYe, Yuanqingen
dc.contributor.authorDiao, Nancyen
dc.contributor.authorSu, Lien
dc.contributor.authorZhang, Ruyangen
dc.contributor.authorBrhane, Yonathanen
dc.contributor.authorLeighl, Natashaen
dc.contributor.authorJohansen, Jakob S.en
dc.contributor.authorMellemgaard, Andersen
dc.contributor.authorSaliba, Waliden
dc.contributor.authorHaiman, Christopheren
dc.contributor.authorWilkens, Lynneen
dc.contributor.authorFernandez-Somoano, Anaen
dc.contributor.authorFernandez-Tardon, Guillermoen
dc.contributor.authorvan der Heijden, Erik H. F. M.en
dc.contributor.authorKim, Jin Heeen
dc.contributor.authorDai, Junchengen
dc.contributor.authorHu, Zhibinen
dc.contributor.authorDavies, Michael P. A.en
dc.contributor.authorMarcus, Michael W.en
dc.contributor.authorBrunnström, Hansen
dc.contributor.authorManjer, Jonasen
dc.contributor.authorMelander, Olleen
dc.contributor.authorMuller, David C.en
dc.contributor.authorOvervad, Kimen
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorDoherty, Jenniferen
dc.contributor.authorGoodman, Gary E.en
dc.contributor.authorCox, Angelaen
dc.contributor.authorTaylor, Fionaen
dc.contributor.authorWoll, Penellaen
dc.contributor.authorBrüske, Ireneen
dc.contributor.authorManz, Judithen
dc.contributor.authorMuley, Thomasen
dc.contributor.authorRisch, Angelaen
dc.contributor.authorRosenberger, Alberten
dc.contributor.authorGrankvist, Kjellen
dc.contributor.authorJohansson, Mikaelen
dc.contributor.authorShepherd, Francesen
dc.contributor.authorTsao, Ming-Sounden
dc.contributor.authorArnold, Susanne M.en
dc.contributor.authorHaura, Eric B.en
dc.contributor.authorBolca, Ciprianen
dc.contributor.authorHolcatova, Ivanaen
dc.contributor.authorJanout, Vladimiren
dc.contributor.authorKontic, Milicaen
dc.contributor.authorLissowska, Jolantaen
dc.contributor.authorMukeria, Anushen
dc.contributor.authorOgnjanovic, Simonaen
dc.contributor.authorOrlowski, Tadeusz M.en
dc.contributor.authorScelo, Ghislaineen
dc.contributor.authorSwiatkowska, Beataen
dc.contributor.authorZaridze, Daviden
dc.contributor.authorBakke, Peren
dc.contributor.authorSkaug, Vidaren
dc.contributor.authorZienolddiny, Shanbehen
dc.contributor.authorDuell, Eric J.en
dc.contributor.authorButler, Lesley M.en
dc.contributor.authorKoh, Woon-Puayen
dc.contributor.authorGao, Yu-Tangen
dc.contributor.authorHoulston, Richarden
dc.contributor.authorMcLaughlin, Johnen
dc.contributor.authorStevens, Victoriaen
dc.contributor.authorNickle, David C.en
dc.contributor.authorObeidat, Ma’enen
dc.contributor.authorTimens, Wimen
dc.contributor.authorZhu, Binen
dc.contributor.authorSong, Leien
dc.contributor.authorArtigas, María Soleren
dc.contributor.authorTobin, Martin D.en
dc.contributor.authorWain, Louise V.en
dc.contributor.authorGu, Fangyien
dc.contributor.authorByun, Jinyoungen
dc.contributor.authorKamal, Ahsanen
dc.contributor.authorZhu, Dakaien
dc.contributor.authorTyndale, Rachel F.en
dc.contributor.authorWei, Wei-Qien
dc.contributor.authorChanock, Stephenen
dc.contributor.authorBrennan, Paulen
dc.contributor.authorAmos, Christopher I.en
dc.date.accessioned2018-12-04T09:28:37Z-
dc.date.available2018-12-04T09:28:37Z-
dc.date.issued2018-08-13-
dc.identifier.citationNature Communications2018, 9 (1):3221en
dc.identifier.issn2041-1723-
dc.identifier.doi10.1038/s41467-018-05074-y-
dc.identifier.urihttp://hdl.handle.net/10146/618230-
dc.description.abstractGenome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.en
dc.language.isoenen
dc.relation.urlhttp://www.nature.com/articles/s41467-018-05074-yen
dc.rightsArchived with thanks to Nature Communicationsen
dc.subjectlung canceren
dc.subjectGenome-Wideen
dc.titleIdentification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risken
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalNature Communicationsen
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