Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population

2.50
Hdl Handle:
http://hdl.handle.net/10146/618229
Title:
Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population
Authors:
Li, Yafang; Xiao, Xiangjun; Han, Younghun; Gorlova, Olga; Qian, David; Leighl, Natasha; Johansen, Jakob S; Barnett, Matt; Chen, Chu; Goodman, Gary; Cox, Angela; Taylor, Fiona; Woll, Penella; Wichmann, H -Erich; Manz, Judith; Muley, Thomas; Risch, Angela; Rosenberger, Albert; Arnold, Susanne M; Haura, Eric B; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolanta; Mukeria, Anush; Ognjanovic, Simona; Orlowski, Tadeusz M; Scelo, Ghislaine; Swiatkowska, Beata; Zaridze, David; Bakke, Per; Skaug, Vidar; Zienolddiny, Shanbeh; Duell, Eric J; Butler, Lesley M; Houlston, Richard; Soler Artigas, María; Grankvist, Kjell; Johansson, Mikael; Shepherd, Frances A; Marcus, Michael W; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C; Overvad, Kim; Trichopoulou, Antonia; Tumino, Rosario; Liu, Geoffrey; Bojesen, Stig E; Wu, Xifeng ( 0000-0001-5174-3769 ) ; Marchand, Loic Le; Albanes, Demetrios; Bickeböller, Heike; Aldrich, Melinda C; Bush, William S; Tardon, Adonina; Rennert, Gad; Teare, M Dawn; Field, John K; Kiemeney, Lambertus A; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B; Andrew, Angeline S; Bertazzi, Pier Alberto; Pesatori, Angela C; Christiani, David C; Caporaso, Neil; Johansson, Mattias; McKay, James D; Brennan, Paul; Hung, Rayjean J; Amos, Christopher I
Abstract:
Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never- versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13336 non-small cell lung cancer cases. Candidate SNPs with P-value <0.001 were further analyzed using a standard case-control interaction analysis including 13970 controls. The significant SNPs with P-value <3.5 × 10-5 (correcting for multiple tests) from the case-control analysis in the discovery stage were further validated using an independent replication dataset comprising 5377 controls and 3054 non-small cell lung cancer cases. We further stratified the analysis by histological subtypes. Two novel SNPs, rs6441286 and rs17723637, were identified for overall lung cancer risk. The interaction odds ratio and meta-analysis P-value for these two SNPs were 1.24 with 6.96 × 10-7 and 1.37 with 3.49 × 10-7, respectively. In addition, interaction of smoking with rs4751674 was identified in squamous cell lung carcinoma with an odds ratio of 0.58 and P-value of 8.12 × 10-7. This study is by far the largest genome-wide SNP-smoking interaction analysis reported for lung cancer. The three identified novel SNPs provide potential candidate biomarkers for lung cancer risk screening and intervention. The results from our study reinforce that gene-smoking interactions play important roles in the etiology of lung cancer and account for part of the missing heritability of this disease.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Carcinogenesis 2018, 39 (3):336
Journal:
Carcinogenesis
Issue Date:
Mar-2018
URI:
http://hdl.handle.net/10146/618229
DOI:
10.1093/carcin/bgx113
Additional Links:
https://academic.oup.com/carcin/article/39/3/336/4558711
Type:
Article
Language:
en
ISSN:
0143-3334; 1460-2180
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Yafangen
dc.contributor.authorXiao, Xiangjunen
dc.contributor.authorHan, Younghunen
dc.contributor.authorGorlova, Olgaen
dc.contributor.authorQian, Daviden
dc.contributor.authorLeighl, Natashaen
dc.contributor.authorJohansen, Jakob Sen
dc.contributor.authorBarnett, Matten
dc.contributor.authorChen, Chuen
dc.contributor.authorGoodman, Garyen
dc.contributor.authorCox, Angelaen
dc.contributor.authorTaylor, Fionaen
dc.contributor.authorWoll, Penellaen
dc.contributor.authorWichmann, H -Erichen
dc.contributor.authorManz, Judithen
dc.contributor.authorMuley, Thomasen
dc.contributor.authorRisch, Angelaen
dc.contributor.authorRosenberger, Alberten
dc.contributor.authorArnold, Susanne Men
dc.contributor.authorHaura, Eric Ben
dc.contributor.authorBolca, Ciprianen
dc.contributor.authorHolcatova, Ivanaen
dc.contributor.authorJanout, Vladimiren
dc.contributor.authorKontic, Milicaen
dc.contributor.authorLissowska, Jolantaen
dc.contributor.authorMukeria, Anushen
dc.contributor.authorOgnjanovic, Simonaen
dc.contributor.authorOrlowski, Tadeusz Men
dc.contributor.authorScelo, Ghislaineen
dc.contributor.authorSwiatkowska, Beataen
dc.contributor.authorZaridze, Daviden
dc.contributor.authorBakke, Peren
dc.contributor.authorSkaug, Vidaren
dc.contributor.authorZienolddiny, Shanbehen
dc.contributor.authorDuell, Eric Jen
dc.contributor.authorButler, Lesley Men
dc.contributor.authorHoulston, Richarden
dc.contributor.authorSoler Artigas, Maríaen
dc.contributor.authorGrankvist, Kjellen
dc.contributor.authorJohansson, Mikaelen
dc.contributor.authorShepherd, Frances Aen
dc.contributor.authorMarcus, Michael Wen
dc.contributor.authorBrunnström, Hansen
dc.contributor.authorManjer, Jonasen
dc.contributor.authorMelander, Olleen
dc.contributor.authorMuller, David Cen
dc.contributor.authorOvervad, Kimen
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorLiu, Geoffreyen
dc.contributor.authorBojesen, Stig Een
dc.contributor.authorWu, Xifengen
dc.contributor.authorMarchand, Loic Leen
dc.contributor.authorAlbanes, Demetriosen
dc.contributor.authorBickeböller, Heikeen
dc.contributor.authorAldrich, Melinda Cen
dc.contributor.authorBush, William Sen
dc.contributor.authorTardon, Adoninaen
dc.contributor.authorRennert, Gaden
dc.contributor.authorTeare, M Dawnen
dc.contributor.authorField, John Ken
dc.contributor.authorKiemeney, Lambertus Aen
dc.contributor.authorLazarus, Philipen
dc.contributor.authorHaugen, Aageen
dc.contributor.authorLam, Stephenen
dc.contributor.authorSchabath, Matthew Ben
dc.contributor.authorAndrew, Angeline Sen
dc.contributor.authorBertazzi, Pier Albertoen
dc.contributor.authorPesatori, Angela Cen
dc.contributor.authorChristiani, David Cen
dc.contributor.authorCaporaso, Neilen
dc.contributor.authorJohansson, Mattiasen
dc.contributor.authorMcKay, James Den
dc.contributor.authorBrennan, Paulen
dc.contributor.authorHung, Rayjean Jen
dc.contributor.authorAmos, Christopher Ien
dc.date.accessioned2018-12-04T09:23:29Z-
dc.date.available2018-12-04T09:23:29Z-
dc.date.issued2018-03-
dc.identifier.citationCarcinogenesis 2018, 39 (3):336en
dc.identifier.issn0143-3334-
dc.identifier.issn1460-2180-
dc.identifier.doi10.1093/carcin/bgx113-
dc.identifier.urihttp://hdl.handle.net/10146/618229-
dc.description.abstractNon-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never- versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13336 non-small cell lung cancer cases. Candidate SNPs with P-value <0.001 were further analyzed using a standard case-control interaction analysis including 13970 controls. The significant SNPs with P-value <3.5 × 10-5 (correcting for multiple tests) from the case-control analysis in the discovery stage were further validated using an independent replication dataset comprising 5377 controls and 3054 non-small cell lung cancer cases. We further stratified the analysis by histological subtypes. Two novel SNPs, rs6441286 and rs17723637, were identified for overall lung cancer risk. The interaction odds ratio and meta-analysis P-value for these two SNPs were 1.24 with 6.96 × 10-7 and 1.37 with 3.49 × 10-7, respectively. In addition, interaction of smoking with rs4751674 was identified in squamous cell lung carcinoma with an odds ratio of 0.58 and P-value of 8.12 × 10-7. This study is by far the largest genome-wide SNP-smoking interaction analysis reported for lung cancer. The three identified novel SNPs provide potential candidate biomarkers for lung cancer risk screening and intervention. The results from our study reinforce that gene-smoking interactions play important roles in the etiology of lung cancer and account for part of the missing heritability of this disease.en
dc.language.isoenen
dc.relation.urlhttps://academic.oup.com/carcin/article/39/3/336/4558711en
dc.rightsArchived with thanks to Carcinogenesisen
dc.subjectsmokingen
dc.subjectlung canceren
dc.subjectcarcinogenesisen
dc.titleGenome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian populationen
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalCarcinogenesisen
dc.contributor.institutionBiomedical Data Science Department, Dartmouth College, Hanover, NH, USA-
dc.contributor.institutionBiomedical Data Science Department, Dartmouth College, Hanover, NH, USA-
dc.contributor.institutionBiomedical Data Science Department, Dartmouth College, Hanover, NH, USA-
dc.contributor.institutionBiomedical Data Science Department, Dartmouth College, Hanover, NH, USA-
dc.contributor.institutionBiomedical Data Science Department, Dartmouth College, Hanover, NH, USA-
dc.contributor.institutionDepartment of Medicine, The Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada-
dc.contributor.institutionDepartment of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen University, Herlev, Denmark-
dc.contributor.institutionPublic Health Sciences Division, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA-
dc.contributor.institutionPublic Health Sciences Division, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA-
dc.contributor.institutionPublic Health Sciences Division, Cancer Prevention Program, Swedish Medical Center, Seattle, WA, USA-
dc.contributor.institutionDepartment of Oncology, University of Sheffield, Sheffield UK-
dc.contributor.institutionDepartment of Oncology, University of Sheffield, Sheffield UK-
dc.contributor.institutionDepartment of Oncology, University of Sheffield, Sheffield UK-
dc.contributor.institutionInstitute of Epidemiology, Helmholtz Centre Munich, Neuherberg, Germany-
dc.contributor.institutionInstitute of Epidemiology, Helmholtz Centre Munich, Neuherberg, Germany-
dc.contributor.institutionBiobank and Tumor Documentation, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany-
dc.contributor.institutionBiobank and Tumor Documentation, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany-
dc.contributor.institutionDepartment of Genetic Epidemiology, Medical School, Georg-August University of Göttingen, Göttingen, Germany-
dc.contributor.institutionMarkey Cancer Center, University of Kentucky, Lexington, KY, USA-
dc.contributor.institutionDepartment of Thoracic Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA-
dc.contributor.institutionThoracic Surgery Division, “Marius Nasta” National Institute of Pneumology, București, Romania-
dc.contributor.institutionFaculty of Medicine, University of Ostrava, Ostrava, Czech Republic-
dc.contributor.institutionFaculty of Medicine, University of Ostrava, Ostrava, Czech Republic-
dc.contributor.institutionInternal Medicine, School of Medicine, Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia-
dc.contributor.institutionDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Institute of Oncology, Warsaw, Pol-
dc.contributor.institutionDepartment of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Centre, Moscow, Russia-
dc.contributor.institutionInternational Organization for Cancer Prevention and Research, Belgrade, Serbia-
dc.contributor.institutionDepartment of Thoracic Surgery, National Institute of Tuberculosis and Lung Diseases, Warsaw, Pol-
dc.contributor.institutionInternational Agency for Research on Cancer (IARC), Genetic Epidemiology Group, Lyon, France-
dc.contributor.institutionDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Pol-
dc.contributor.institutionDepartment of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Centre, Moscow, Russia-
dc.contributor.institutionDepartment of Clinical Science, University of Bergen, Bergen, Norway-
dc.contributor.institutionDepartment of Toxicology, National Institute of Occupational Health, Oslo, Norway-
dc.contributor.institutionDepartment of Toxicology, National Institute of Occupational Health, Oslo, Norway-
dc.contributor.institutionUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Hospitalet de Llobregat, Barcelona, Spain-
dc.contributor.institutionUniversity of Pittsburgh Cancer Institute, Pittsburgh, PA, USA-
dc.contributor.institutionThe Institute of Cancer Research, London, UK-
dc.contributor.institutionDepartment of Health Sciences, Genetic Epidemiology Group, University of Leicester, Leicester, UK-
dc.contributor.institutionDepartment of Medical Biosciences, Umeå University, Umeå, Sweden-
dc.contributor.institutionDepartment of Radiation Sciences, Umeå University, Umeå, Sweden-
dc.contributor.institutionMedical Oncology Toronto, Princess Margaret Hospital, Toronto, ON, Canada-
dc.contributor.institutionDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK-
dc.contributor.institutionDepartment of Clinical Sciences, Lund University, Lund, Sweden-
dc.contributor.institutionDepartment of Internal Medicine, Skåne University Hospital, Malmö, Sweden-
dc.contributor.institutionDepartment of Clinical Sciences, Lund University, Lund, Sweden-
dc.contributor.institutionDepartment of Epidemiology and Biostatistics, Imperial College London, St Mary’s Campus, London, UK-
dc.contributor.institutionSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus C, Denmark-
dc.contributor.institutionDepartment of Hygiene and Epidemiology, Medical School, University of Athens, Athens, Greece-
dc.contributor.institutionMolecular and Nutritional Epidemiology Unit, CSPO (Cancer Research and Prevention Centre), Scientific Institute of Tuscany, Florence, Italy-
dc.contributor.institutionPrincess Margaret Cancer Centre, Toronto, ON M5G, Canada-
dc.contributor.institutionDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark-
dc.contributor.institutionDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA-
dc.contributor.institutionEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA-
dc.contributor.institutionDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA-
dc.contributor.institutionDepartment of Genetic Epidemiology, University Medical Center, Georg-August University Göttingen, Göttingen, Germany-
dc.contributor.institutionDepartment of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA-
dc.contributor.institutionDepartment of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA-
dc.contributor.institutionMedicina, IUOPA-Universidad de Oviedo, Oviedo, Spain-
dc.contributor.institutionTechnion Faculty of Medicine, Clalit National Cancer Control Center, Carmel Medical Center, Haifa, Israel-
dc.contributor.institutionGenetic Epidemiology, School of Health and Related Research, University of Sheffield, Sheffield, UK-
dc.contributor.institutionInstitute of Translational Medicine, University of Liverpool, Liverpool, UK-
dc.contributor.institutionDepartment for Health Evidence, Radboud University Medical Center, Nijmegen EZ, Netherlands-
dc.contributor.institutionDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, USA-
dc.contributor.institutionDepartment of Toxicology, National Institute of Occupational Health, Oslo, Norway-
dc.contributor.institutionDepartment of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada-
dc.contributor.institutionDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA-
dc.contributor.institutionDepartment of Epidemiology, Norris Cotton Cancer Center, Dartmouth College, Hanover, NH, USA-
dc.contributor.institutionDepartment of Preventive Medicine, IRCCS Foundation Cà Granda Ospedale, Maggiore Policlinico, University of Milan, Milan, Italy-
dc.contributor.institutionDepartment of Clinical Sciences and Community Health–DISCCO, University of Milan, Milan, Italy-
dc.contributor.institutionDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA-
dc.contributor.institutionDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA-
dc.contributor.institutionInternational Agency for Research on Cancer, World Health Organization, Lyon, France-
dc.contributor.institutionInternational Agency for Research on Cancer (IARC), Genetic Epidemiology Group, Lyon, France-
dc.contributor.institutionInternational Agency for Research on Cancer, World Health Organization, Lyon, France-
dc.contributor.institutionDivision of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada-
dc.contributor.institutionBiomedical Data Science Department, Dartmouth College, Hanover, NH, USA-
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