Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

2.50
Hdl Handle:
http://hdl.handle.net/10146/618228
Title:
Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis
Authors:
Pastorino, Roberta; Puggina, Anna; Carreras-Torres, Robert; Lagiou, Pagona; Holcátová, Ivana; Richiardi, Lorenzo; Kjaerheim, Kristina; Agudo, Antonio; Castellsagué, Xavier; Macfarlane, Tatiana V.; Barzan, Luigi; Canova, Cristina; Thakker, Nalin S.; Conway, David I.; Znaor, Ariana; Healy, Claire M.; Ahrens, Wolfgang; Zaridze, David; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Fabianova, Eleonora; Mates, Ioan Nicolae; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Brennan, Paul; Gaborieau, Valérie; McKay, James D.; Boccia, Stefania
Abstract:
With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95%CI), 0.99–1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69–0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.
Affiliation:
Nofer Institute of Occupational Medicine
Citation:
Scientific Reports2018, 8 (1): art.4534
Journal:
Scientific Reports
Issue Date:
14-Mar-2018
URI:
http://hdl.handle.net/10146/618228
DOI:
10.1038/s41598-018-22626-w
Additional Links:
http://www.nature.com/articles/s41598-018-22626-w
Type:
Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPastorino, Robertaen
dc.contributor.authorPuggina, Annaen
dc.contributor.authorCarreras-Torres, Roberten
dc.contributor.authorLagiou, Pagonaen
dc.contributor.authorHolcátová, Ivanaen
dc.contributor.authorRichiardi, Lorenzoen
dc.contributor.authorKjaerheim, Kristinaen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorCastellsagué, Xavieren
dc.contributor.authorMacfarlane, Tatiana V.en
dc.contributor.authorBarzan, Luigien
dc.contributor.authorCanova, Cristinaen
dc.contributor.authorThakker, Nalin S.en
dc.contributor.authorConway, David I.en
dc.contributor.authorZnaor, Arianaen
dc.contributor.authorHealy, Claire M.en
dc.contributor.authorAhrens, Wolfgangen
dc.contributor.authorZaridze, Daviden
dc.contributor.authorSzeszenia-Dabrowska, Neoniliaen
dc.contributor.authorLissowska, Jolantaen
dc.contributor.authorFabianova, Eleonoraen
dc.contributor.authorMates, Ioan Nicolaeen
dc.contributor.authorBencko, Vladimiren
dc.contributor.authorForetova, Lenkaen
dc.contributor.authorJanout, Vladimiren
dc.contributor.authorBrennan, Paulen
dc.contributor.authorGaborieau, Valérieen
dc.contributor.authorMcKay, James D.en
dc.contributor.authorBoccia, Stefaniaen
dc.date.accessioned2018-12-04T09:17:35Z-
dc.date.available2018-12-04T09:17:35Z-
dc.date.issued2018-03-14-
dc.identifier.citationScientific Reports2018, 8 (1): art.4534en
dc.identifier.issn2045-2322-
dc.identifier.doi10.1038/s41598-018-22626-w-
dc.identifier.urihttp://hdl.handle.net/10146/618228-
dc.description.abstractWith the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95%CI), 0.99–1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69–0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.en
dc.language.isoenen
dc.relation.urlhttp://www.nature.com/articles/s41598-018-22626-wen
dc.rightsArchived with thanks to Scientific Reportsen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcancer epidemiologyen
dc.subjectrisk factorsen
dc.titleGenetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysisen
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicineen
dc.identifier.journalScientific Reportsen
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