Biomarkers of exposure in environment-wide association studies - Opportunities to decode the exposome using human biomonitoring data.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618209
Title:
Biomarkers of exposure in environment-wide association studies - Opportunities to decode the exposome using human biomonitoring data.
Authors:
Steckling, Nadine; Gotti, Alberto; Bose-O'Reilly, Stephan; Chapizanis, Dimitris; Costopoulou, Danae; De Vocht, Frank; Garí, Mercè; Grimalt, Joan O; Heath, Ester; Hiscock, Rosemary; Jagodic, Marta; Karakitsios, Spyros P; Kedikoglou, Kleopatra; Kosjek, Tina; Leondiadis, Leondios; Maggos, Thomas; Mazej, Darja; Polanska, Kinga ( 0000-0002-3212-2307 ) ; Povey, Andrew; Rovira, Joaquim; Schoierer, Julia; Schuhmacher, Marta; Špirić, Zdravko; Stajnko, Anja; Stierum, Rob; Tratnik, Janja Snoj; Vassiliadou, Irene; Annesi-Maesano, Isabella; Horvat, Milena; Sarigiannis, Dimosthenis A
Abstract:
The European Union's 7th Framework Programme (EU's FP7) project HEALS - Health and Environment-wide Associations based on Large Population Surveys - aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific biomarkers of exposure (BoE) is limited.; The objective was to summarize the availability of BoEs for a broad range of environmental stressors and exposure determinants and corresponding reference and exposure limit values and biomonitoring equivalents useful for unraveling the exposome using the framework of environment-wide association studies (EWAS).; In a face-to-face group discussion, scope, content, and structure of the HEALS deliverable "Guidelines for appropriate BoE selection for EWAS studies" were determined. An expert-driven, distributed, narrative review process involving around 30 individuals of the HEALS consortium made it possible to include extensive information targeted towards the specific characteristics of various environmental stressors and exposure determinants. From the resulting 265 page report, targeted information about BoE, corresponding reference values (e.g., 95th percentile or measures of central tendency), exposure limit values (e.g., the German HBM I and II values) and biomonitoring equivalents (BEs) were summarized and updated.; 64 individual biological, chemical, physical, psychological and social environmental stressors or exposure determinants were included to fulfil the requirements of EWAS. The list of available BoEs is extensive with a number of 135; however, 12 of the stressors and exposure determinants considered do not leave any measurable specific substance in accessible body specimens. Opportunities to estimate the internal exposure stressors not (yet) detectable in human specimens were discussed.; Data about internal exposures are useful to decode the exposome. The paper provides extensive information for EWAS. Information included serves as a guideline - snapshot in time without any claim to comprehensiveness - to interpret HBM data and offers opportunities to collect information about the internal exposure of stressors if no specific BoE is available.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Citation:
Environ. Res. 2018, 164:597-624
Journal:
Environmental Research
Issue Date:
4-Apr-2018
URI:
http://hdl.handle.net/10146/618209
DOI:
10.1016/j.envres.2018.02.041
PubMed ID:
29626821
Additional Links:
https://www.sciencedirect.com/science/article/pii/S0013935118301166
Type:
Article
Language:
en
ISSN:
1096-0953
Sponsors:
This work has received funding from the European Union's Seventh Programme for research, technological development and demonstration under grant agreement No. 603946 (Health and Environment-wide Associations based on Large population Surveys, HEALS). All HEALS partners involved in the discussion of deliverable 4.2 during the annual HEALS meeting in Edinburgh, UK, on September 16, 2014, are grate-fully acknowledged. Special thanks go to our colleagues outside WP4 and outside HEALS who reviewed chapters of their expertise: Thank you, Tomislav Bituh, Danijela Š timac, and Matthias Weigl.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSteckling, Nadineen
dc.contributor.authorGotti, Albertoen
dc.contributor.authorBose-O'Reilly, Stephanen
dc.contributor.authorChapizanis, Dimitrisen
dc.contributor.authorCostopoulou, Danaeen
dc.contributor.authorDe Vocht, Franken
dc.contributor.authorGarí, Mercèen
dc.contributor.authorGrimalt, Joan Oen
dc.contributor.authorHeath, Esteren
dc.contributor.authorHiscock, Rosemaryen
dc.contributor.authorJagodic, Martaen
dc.contributor.authorKarakitsios, Spyros Pen
dc.contributor.authorKedikoglou, Kleopatraen
dc.contributor.authorKosjek, Tinaen
dc.contributor.authorLeondiadis, Leondiosen
dc.contributor.authorMaggos, Thomasen
dc.contributor.authorMazej, Darjaen
dc.contributor.authorPolanska, Kingaen
dc.contributor.authorPovey, Andrewen
dc.contributor.authorRovira, Joaquimen
dc.contributor.authorSchoierer, Juliaen
dc.contributor.authorSchuhmacher, Martaen
dc.contributor.authorŠpirić, Zdravkoen
dc.contributor.authorStajnko, Anjaen
dc.contributor.authorStierum, Roben
dc.contributor.authorTratnik, Janja Snojen
dc.contributor.authorVassiliadou, Ireneen
dc.contributor.authorAnnesi-Maesano, Isabellaen
dc.contributor.authorHorvat, Milenaen
dc.contributor.authorSarigiannis, Dimosthenis Aen
dc.date.accessioned2018-04-09T11:47:55Z-
dc.date.available2018-04-09T11:47:55Z-
dc.date.issued2018-04-04-
dc.identifier.citationEnviron. Res. 2018, 164:597-624en
dc.identifier.issn1096-0953-
dc.identifier.pmid29626821-
dc.identifier.doi10.1016/j.envres.2018.02.041-
dc.identifier.urihttp://hdl.handle.net/10146/618209-
dc.description.abstractThe European Union's 7th Framework Programme (EU's FP7) project HEALS - Health and Environment-wide Associations based on Large Population Surveys - aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific biomarkers of exposure (BoE) is limited.en
dc.description.abstractThe objective was to summarize the availability of BoEs for a broad range of environmental stressors and exposure determinants and corresponding reference and exposure limit values and biomonitoring equivalents useful for unraveling the exposome using the framework of environment-wide association studies (EWAS).en
dc.description.abstractIn a face-to-face group discussion, scope, content, and structure of the HEALS deliverable "Guidelines for appropriate BoE selection for EWAS studies" were determined. An expert-driven, distributed, narrative review process involving around 30 individuals of the HEALS consortium made it possible to include extensive information targeted towards the specific characteristics of various environmental stressors and exposure determinants. From the resulting 265 page report, targeted information about BoE, corresponding reference values (e.g., 95th percentile or measures of central tendency), exposure limit values (e.g., the German HBM I and II values) and biomonitoring equivalents (BEs) were summarized and updated.en
dc.description.abstract64 individual biological, chemical, physical, psychological and social environmental stressors or exposure determinants were included to fulfil the requirements of EWAS. The list of available BoEs is extensive with a number of 135; however, 12 of the stressors and exposure determinants considered do not leave any measurable specific substance in accessible body specimens. Opportunities to estimate the internal exposure stressors not (yet) detectable in human specimens were discussed.en
dc.description.abstractData about internal exposures are useful to decode the exposome. The paper provides extensive information for EWAS. Information included serves as a guideline - snapshot in time without any claim to comprehensiveness - to interpret HBM data and offers opportunities to collect information about the internal exposure of stressors if no specific BoE is available.en
dc.description.sponsorshipThis work has received funding from the European Union's Seventh Programme for research, technological development and demonstration under grant agreement No. 603946 (Health and Environment-wide Associations based on Large population Surveys, HEALS). All HEALS partners involved in the discussion of deliverable 4.2 during the annual HEALS meeting in Edinburgh, UK, on September 16, 2014, are grate-fully acknowledged. Special thanks go to our colleagues outside WP4 and outside HEALS who reviewed chapters of their expertise: Thank you, Tomislav Bituh, Danijela Š timac, and Matthias Weigl.en
dc.language.isoenen
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0013935118301166en
dc.rightsArchived with thanks to Environmental researchen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiomarkers of exposureen
dc.subjectBiomonitoring equivalentsen
dc.subjectEnvironment-wide association studiesen
dc.subjectExposure limit valuesen
dc.subjectHuman biomonitoringen
dc.subjectReference valuesen
dc.titleBiomarkers of exposure in environment-wide association studies - Opportunities to decode the exposome using human biomonitoring data.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalEnvironmental Researchen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.