Air Pollution and Human Sperm Sex Ratio.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618199
Title:
Air Pollution and Human Sperm Sex Ratio.
Authors:
Radwan, Michał; Dziewirska, Emila; Radwan, Paweł; Jakubowski, Lucjusz; Hanke, Wojciech ( 0000-0001-7162-2569 ) ; Jurewicz, Joanna ( 0000-0001-9645-0134 )
Abstract:
The present study was designed to address the hypothesis that exposure to specific air pollutants may impact human sperm Y:X chromosome ratio. The study population consisted of 195 men who were attending an infertility clinic for diagnostic purposes and who had normal semen concentration of 15-300 mln/ml (WHO, 2010). Participants represented a subset of men in a multicenter parent study conducted in Poland to evaluate environmental factors and male fertility. Participants were interviewed and provided a semen sample. The Y:X ratio was assessed by fluorescent in situ hybridization (FISH). Air quality data were obtained from the AirBase database. In multivariate analysis the significant reduction was observed in the proportion of Y/X chromosome bearing sperm and exposure to particulate matter >10 μm in aerodynamic diameter PM10( p = .009) and particulate matter <10 μm in aerodynamic diameter PM2.5( p = .023). The observed effects of a lower Y:X sperm chromosome ratio among men exposed to air pollution support the evidence that the trend of declining sex ratio in several societies over past decades has been due to exposure to air pollution; however due to limited data on this issue, the obtained results should be confirmed in longitudinal studies.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Citation:
Am J Mens Health 2018:1557988317752608
Journal:
American Journal of Men's Health
Issue Date:
1-Jan-2018
URI:
http://hdl.handle.net/10146/618199
DOI:
10.1177/1557988317752608
PubMed ID:
29320903
Additional Links:
http://journals.sagepub.com/doi/abs/10.1177/1557988317752608?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#articleCitationDownloadContainer
Type:
Article
Language:
en
ISSN:
1557-9891
Sponsors:
This study was performed under the project “The association between environmental exposure to widespread man made endocrine disrupting chemicals and level of hormones associated with the activity of hypothalamic pituitary testicular axis among young men” supported by National Science Centre in Poland from grant no. UMO-2014/13/B/NZ7/02223 and the project financed with a grant for statutory activity IMP 10.23/2015.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorRadwan, Michałen
dc.contributor.authorDziewirska, Emilaen
dc.contributor.authorRadwan, Pawełen
dc.contributor.authorJakubowski, Lucjuszen
dc.contributor.authorHanke, Wojciechen
dc.contributor.authorJurewicz, Joannaen
dc.date.accessioned2018-02-21T10:44:17Z-
dc.date.available2018-02-21T10:44:17Z-
dc.date.issued2018-01-01-
dc.identifier.citationAm J Mens Health 2018:1557988317752608en
dc.identifier.issn1557-9891-
dc.identifier.pmid29320903-
dc.identifier.doi10.1177/1557988317752608-
dc.identifier.urihttp://hdl.handle.net/10146/618199-
dc.description.abstractThe present study was designed to address the hypothesis that exposure to specific air pollutants may impact human sperm Y:X chromosome ratio. The study population consisted of 195 men who were attending an infertility clinic for diagnostic purposes and who had normal semen concentration of 15-300 mln/ml (WHO, 2010). Participants represented a subset of men in a multicenter parent study conducted in Poland to evaluate environmental factors and male fertility. Participants were interviewed and provided a semen sample. The Y:X ratio was assessed by fluorescent in situ hybridization (FISH). Air quality data were obtained from the AirBase database. In multivariate analysis the significant reduction was observed in the proportion of Y/X chromosome bearing sperm and exposure to particulate matter >10 μm in aerodynamic diameter PM10( p = .009) and particulate matter <10 μm in aerodynamic diameter PM2.5( p = .023). The observed effects of a lower Y:X sperm chromosome ratio among men exposed to air pollution support the evidence that the trend of declining sex ratio in several societies over past decades has been due to exposure to air pollution; however due to limited data on this issue, the obtained results should be confirmed in longitudinal studies.en
dc.description.sponsorshipThis study was performed under the project “The association between environmental exposure to widespread man made endocrine disrupting chemicals and level of hormones associated with the activity of hypothalamic pituitary testicular axis among young men” supported by National Science Centre in Poland from grant no. UMO-2014/13/B/NZ7/02223 and the project financed with a grant for statutory activity IMP 10.23/2015.en
dc.language.isoenen
dc.relation.urlhttp://journals.sagepub.com/doi/abs/10.1177/1557988317752608?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#articleCitationDownloadContaineren
dc.rightsArchived with thanks to American journal of men's healthen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectsex ratioen
dc.subjectair pollutionen
dc.subjectspermen
dc.subjectmale fertilityen
dc.subjectenvironmental exposureen
dc.titleAir Pollution and Human Sperm Sex Ratio.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalAmerican Journal of Men's Healthen

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