Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?

2.50
Hdl Handle:
http://hdl.handle.net/10146/77963
Title:
Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
Authors:
Loft, Steffen; Moller, Peter; Cooke, Marcus S.; Rozalski, Rafal; Olinski, Ryszard
Abstract:
Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.
Citation:
Eur. J. Nutr. 2008, 47 Suppl 2:19-28
Journal:
European journal of nutrition
Issue Date:
May-2008
URI:
http://hdl.handle.net/10146/77963
DOI:
10.1007/s00394-008-2004-0
PubMed ID:
18458832
Additional Links:
http://www.springerlink.com/content/b8711066866343k5/
Type:
Article
Language:
en
ISSN:
1436-6207
Sponsors:
This review was written as a part of the research integration in the Workpackage “Mechanisms of modulation of cancer by dietary factors” in the NoE Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS, no. 513943; www.ecnis.org).”
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorLoft, Steffen-
dc.contributor.authorMoller, Peter-
dc.contributor.authorCooke, Marcus S.-
dc.contributor.authorRozalski, Rafal-
dc.contributor.authorOlinski, Ryszard-
dc.date.accessioned2009-08-20T11:27:52Z-
dc.date.available2009-08-20T11:27:52Z-
dc.date.issued2008-05-
dc.identifier.citationEur. J. Nutr. 2008, 47 Suppl 2:19-28en
dc.identifier.issn1436-6207-
dc.identifier.pmid18458832-
dc.identifier.doi10.1007/s00394-008-2004-0-
dc.identifier.urihttp://hdl.handle.net/10146/77963-
dc.description.abstractOxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.en
dc.description.sponsorshipThis review was written as a part of the research integration in the Workpackage “Mechanisms of modulation of cancer by dietary factors” in the NoE Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS, no. 513943; www.ecnis.org).”en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/b8711066866343k5/en
dc.subjectantioxidantsen
dc.subjectcomet assayen
dc.subject8-oxodGen
dc.subjectoxidative stressen
dc.subjectoxidative damage to DNAen
dc.subject.meshAntioxidants-
dc.subject.meshComet Assay-
dc.subject.meshDNA Damage-
dc.subject.meshDNA Repair-
dc.subject.meshDeoxyguanosine-
dc.subject.meshDiet-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshNutritional Physiological Phenomena-
dc.subject.meshOxidation-Reduction-
dc.subject.meshOxidative Stress-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshReactive Oxygen Species-
dc.subject.meshRisk Factors-
dc.subject.meshTumor Markers, Biological-
dc.subject.meshVitamins-
dc.titleAntioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?en
dc.typeArticleen
dc.identifier.journalEuropean journal of nutritionen

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