Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10146/77374
Title:
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.
Authors:
Kiemeney, Lambertus A.; Thorlacius, Steinunn; Sulem, Patrick; Geller, Frank; Aben, Katja K.H.; Stacey, Simon N.; Gudmundsson, Julius; Jakobsdottir, Margret; Bergthorsson, Jon T..; Sigurdsson, Asgeir; Blondal, Thorarinn; Witjes, J. Alfred; Vermeulen, Sita H.; Hulsbergen-van de Kaa, Christina A.; Swinkels, Dorine W.; Ploeg, Martine; Cornel, Erik B.; Vergunst, Henk; Thorgeirsson, Thorgeir E.; Gudbjartsson, Daniel; Gudjonsson, Sigurjon A.; Thorleifsson, Gudmar; Kristinsson, Kari T.; Mouy, Magali; Snorradottir, Steinunn; Placidi, Donatella; Campagna, Marcello; Arici, Cecilia; Koppova, Kvetoslava; Gurzau, Eugene; Rudnai, Peter; Kellen, Eliane; Polidoro, Silvia; Guarrera, Simonetta; Sacerdote, Carlotta; Sanchez, Manuel; Saez, Berta; Valdivia, Gabriel; Ryk, Charlotta; de Verdier, Petra; Lindblom, Annika; Golka, Klaus; Bishop, D. Timothy; Knowles, Margaret A.; Nikulasson, Sigfus; Petursdottir, Vigdis; Jonsson, Eirikur; Geirsson, Gudmundur; Kristjansson, Baldvin; Mayordomo, Jose I.; Steineck, Gunnar; Porru, Stefano; Buntinx, Frank; Zeegers, Maurice P.; Fletcher, Tony; Kumar, Rajiv; Matullo, Giuseppe; Vineis, Paolo; Kiltie, Anne E; Gulcher, Jeffrey R..; Thorsteinsdottir, Unnur; Kong, Augustine; Rafnar, Thorunn; Stefansson, Kari
Abstract:
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).
Citation:
Nat. Genet. 2008, 40 (11):1307-1312
Journal:
Nature genetics
Issue Date:
Nov-2008
URI:
http://hdl.handle.net/10146/77374
DOI:
10.1038/ng.229
PubMed ID:
18794855
Additional Links:
http://www.nature.com/ng/journal/v40/n11/abs/ng.229.html
Type:
Article
Language:
en
Description:
Comment in: Eur Urol. 2009 Jun;55(6):1487-8. Eur Urol. 2009 May;55(5):1237.
ISSN:
1546-1718
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorKiemeney, Lambertus A.-
dc.contributor.authorThorlacius, Steinunn-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorGeller, Frank-
dc.contributor.authorAben, Katja K.H.-
dc.contributor.authorStacey, Simon N.-
dc.contributor.authorGudmundsson, Julius-
dc.contributor.authorJakobsdottir, Margret-
dc.contributor.authorBergthorsson, Jon T..-
dc.contributor.authorSigurdsson, Asgeir-
dc.contributor.authorBlondal, Thorarinn-
dc.contributor.authorWitjes, J. Alfred-
dc.contributor.authorVermeulen, Sita H.-
dc.contributor.authorHulsbergen-van de Kaa, Christina A.-
dc.contributor.authorSwinkels, Dorine W.-
dc.contributor.authorPloeg, Martine-
dc.contributor.authorCornel, Erik B.-
dc.contributor.authorVergunst, Henk-
dc.contributor.authorThorgeirsson, Thorgeir E.-
dc.contributor.authorGudbjartsson, Daniel-
dc.contributor.authorGudjonsson, Sigurjon A.-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorKristinsson, Kari T.-
dc.contributor.authorMouy, Magali-
dc.contributor.authorSnorradottir, Steinunn-
dc.contributor.authorPlacidi, Donatella-
dc.contributor.authorCampagna, Marcello-
dc.contributor.authorArici, Cecilia-
dc.contributor.authorKoppova, Kvetoslava-
dc.contributor.authorGurzau, Eugene-
dc.contributor.authorRudnai, Peter-
dc.contributor.authorKellen, Eliane-
dc.contributor.authorPolidoro, Silvia-
dc.contributor.authorGuarrera, Simonetta-
dc.contributor.authorSacerdote, Carlotta-
dc.contributor.authorSanchez, Manuel-
dc.contributor.authorSaez, Berta-
dc.contributor.authorValdivia, Gabriel-
dc.contributor.authorRyk, Charlotta-
dc.contributor.authorde Verdier, Petra-
dc.contributor.authorLindblom, Annika-
dc.contributor.authorGolka, Klaus-
dc.contributor.authorBishop, D. Timothy-
dc.contributor.authorKnowles, Margaret A.-
dc.contributor.authorNikulasson, Sigfus-
dc.contributor.authorPetursdottir, Vigdis-
dc.contributor.authorJonsson, Eirikur-
dc.contributor.authorGeirsson, Gudmundur-
dc.contributor.authorKristjansson, Baldvin-
dc.contributor.authorMayordomo, Jose I.-
dc.contributor.authorSteineck, Gunnar-
dc.contributor.authorPorru, Stefano-
dc.contributor.authorBuntinx, Frank-
dc.contributor.authorZeegers, Maurice P.-
dc.contributor.authorFletcher, Tony-
dc.contributor.authorKumar, Rajiv-
dc.contributor.authorMatullo, Giuseppe-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorKiltie, Anne E-
dc.contributor.authorGulcher, Jeffrey R..-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorKong, Augustine-
dc.contributor.authorRafnar, Thorunn-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2009-08-14T11:14:49Z-
dc.date.available2009-08-14T11:14:49Z-
dc.date.issued2008-11-
dc.identifier.citationNat. Genet. 2008, 40 (11):1307-1312en
dc.identifier.issn1546-1718-
dc.identifier.pmid18794855-
dc.identifier.doi10.1038/ng.229-
dc.identifier.urihttp://hdl.handle.net/10146/77374-
dc.descriptionComment in: Eur Urol. 2009 Jun;55(6):1487-8. Eur Urol. 2009 May;55(5):1237.en
dc.description.abstractWe conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).en
dc.language.isoenen
dc.relation.urlhttp://www.nature.com/ng/journal/v40/n11/abs/ng.229.htmlen
dc.subjectChromosomes, Human, Pair 3en
dc.subjectChromosomes, Human, Pair 8en
dc.subjectGenetic Markersen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectLinkage Disequilibriumen
dc.subjectMutationen
dc.subjectUrinary Bladder Neoplasmsen
dc.subjectCase-Control Studiesen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBase Sequence-
dc.subject.meshCase-Control Studies-
dc.subject.meshChromosomes, Human, Pair 3-
dc.subject.meshChromosomes, Human, Pair 8-
dc.subject.meshFemale-
dc.subject.meshGenetic Markers-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHumans-
dc.subject.meshLinkage Disequilibrium-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMutation-
dc.subject.meshUrinary Bladder Neoplasms-
dc.titleSequence variant on 8q24 confers susceptibility to urinary bladder cancer.en
dc.typeArticleen
dc.identifier.journalNature geneticsen

Related articles on PubMed

All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.