Short-term effects of selenium supplementation of cows' feed on the content and distribution of selenium, copper and zinc in bovine milk, whey and blood plasma.

2.50
Hdl Handle:
http://hdl.handle.net/10146/76775
Title:
Short-term effects of selenium supplementation of cows' feed on the content and distribution of selenium, copper and zinc in bovine milk, whey and blood plasma.
Authors:
Hoac, Tien; Stagsted, Jan; Lundh, Thomas; Nielsen, Jacob H.; Akesson, Bjorn
Abstract:
The effect of selenium supplementation of feed on the Se content in bovine milk, whey and plasma, and on the distribution of Se, Zn and Cu in whey and plasma was investigated. In a cross-over study two groups of cows were given a basal feed with 0.16 ppm selenite (approx. 3 mg Se/d) with or without 25 mg yeast Se/d for 2 weeks. In the supplemented group the Se content increased 10-fold in milk, 10-fold in whey and 2-fold in plasma, and after the cessation of the supplementation, selenium in milk decreased with a calculated half-life of 3.5 d. In another experiment, two groups of cows were given either 100 mg yeast Se/d for 1 week or only the basal feed. The increase in Se content in both whole and defatted milk was 40-50-fold, and in whey it was approx. 20-fold. Size-exclusion chromatography of whey using inductively coupled plasma mass spectrometry for detection showed that supplementation increased the proportion of Se in the beta-lactoglobulin-alpha-lactalbumin fraction. Distribution of Cu and Zn was essentially unaffected. In plasma, supplementation increased the Se content in all major Se fractions like selenoprotein P, albumin and low-molecular-weight compounds, but the distribution profiles of Zn and Cu underwent no major changes. The study showed for the first time the rapid kinetics of the Se increase and decrease in milk after the initiation and cessation of supplementation, respectively, and the preferential appearance of Se in the beta-lactoglobulin-alpha-lactalbumin fraction of whey. Milk highly enriched in selenium will be a useful tool for different research purposes.
Citation:
J. Dairy Res. 2008, 75 (3):326-334
Journal:
The Journal of dairy research
Issue Date:
Aug-2008
URI:
http://hdl.handle.net/10146/76775
DOI:
10.1017/S0022029908003324
PubMed ID:
18680617
Additional Links:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=2004548
Type:
Article
Language:
en
ISSN:
0022-0299
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorHoac, Tien-
dc.contributor.authorStagsted, Jan-
dc.contributor.authorLundh, Thomas-
dc.contributor.authorNielsen, Jacob H.-
dc.contributor.authorAkesson, Bjorn-
dc.date.accessioned2009-08-10T08:58:09Z-
dc.date.available2009-08-10T08:58:09Z-
dc.date.issued2008-08-
dc.identifier.citationJ. Dairy Res. 2008, 75 (3):326-334en
dc.identifier.issn0022-0299-
dc.identifier.pmid18680617-
dc.identifier.doi10.1017/S0022029908003324-
dc.identifier.urihttp://hdl.handle.net/10146/76775-
dc.description.abstractThe effect of selenium supplementation of feed on the Se content in bovine milk, whey and plasma, and on the distribution of Se, Zn and Cu in whey and plasma was investigated. In a cross-over study two groups of cows were given a basal feed with 0.16 ppm selenite (approx. 3 mg Se/d) with or without 25 mg yeast Se/d for 2 weeks. In the supplemented group the Se content increased 10-fold in milk, 10-fold in whey and 2-fold in plasma, and after the cessation of the supplementation, selenium in milk decreased with a calculated half-life of 3.5 d. In another experiment, two groups of cows were given either 100 mg yeast Se/d for 1 week or only the basal feed. The increase in Se content in both whole and defatted milk was 40-50-fold, and in whey it was approx. 20-fold. Size-exclusion chromatography of whey using inductively coupled plasma mass spectrometry for detection showed that supplementation increased the proportion of Se in the beta-lactoglobulin-alpha-lactalbumin fraction. Distribution of Cu and Zn was essentially unaffected. In plasma, supplementation increased the Se content in all major Se fractions like selenoprotein P, albumin and low-molecular-weight compounds, but the distribution profiles of Zn and Cu underwent no major changes. The study showed for the first time the rapid kinetics of the Se increase and decrease in milk after the initiation and cessation of supplementation, respectively, and the preferential appearance of Se in the beta-lactoglobulin-alpha-lactalbumin fraction of whey. Milk highly enriched in selenium will be a useful tool for different research purposes.en
dc.language.isoenen
dc.relation.urlhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=2004548en
dc.subjectblood plasmaen
dc.subjectICP-MSen
dc.subjectmilken
dc.subjectwheyen
dc.subjecttrace element distributionen
dc.subjectZnen
dc.subjectSe supplementationen
dc.subjectCuen
dc.subject.meshAnimal Feed-
dc.subject.meshAnimals-
dc.subject.meshCattle-
dc.subject.meshCopper-
dc.subject.meshDietary Supplements-
dc.subject.meshFemale-
dc.subject.meshMilk-
dc.subject.meshSelenium-
dc.subject.meshTime Factors-
dc.subject.meshZinc-
dc.titleShort-term effects of selenium supplementation of cows' feed on the content and distribution of selenium, copper and zinc in bovine milk, whey and blood plasma.en
dc.typeArticleen
dc.identifier.journalThe Journal of dairy researchen

Related articles on PubMed

All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.