Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements.

2.50
Hdl Handle:
http://hdl.handle.net/10146/76635
Title:
Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements.
Authors:
Gromadzinska, Jolanta; Reszka, Edyta ( 0000-0003-2153-4864 ) ; Bruzelius, Katharina; Wasowicz, Wojciech ( 0000-0002-2991-9040 ) ; Akesson, Bjorn
Abstract:
BACKGROUND: The relationship between selenium and cancer involves many different aspects. These include the forms of selenium present in the diet and in the body, their functions and mechanisms of action, and methods employed in assessing an individual's selenium nutritional status-both in general, and in epidemiological studies of the risk of cancer in relation to diet, as well as in connection with long-term trials for investigating the disease-preventive potential of selenium supplementation. AIM OF THE REVIEW: To review different aspects on selenium metabolism, the occurrence of different selenoproteins and their use as biomarkers of selenium status, the results of intervention trials of the cancer-preventive effects of selenium supplementation, the mechanisms of action involved, together with epidemiological findings on relations between the selenium status in the body and risk of cancer. RESULTS AND CONCLUSIONS: The rapid advance in the knowledge of different selenoproteins and their biological functions has opened up new possibilities for the understanding of the biological effects of selenium supplementation. A wide variety of effects of different forms and doses of selenium has been observed in a number of experimental systems, and it is at present difficult to pinpoint the mechanism that may explain the positive preventive effects of selenium supplementation observed in some human long-term trials. Moreover, additional such trials are needed to define the benefits and risks of different types and doses of selenium supplements which in the future may be implemented for public health reasons. Another necessary focus for future research is a better understanding of the mechanisms by which selenium interferes with the carcinogenesis process.
Citation:
Eur. J. Nutr. 2008, 47 Suppl 2:29-50
Journal:
European journal of nutrition
Issue Date:
May-2008
URI:
http://hdl.handle.net/10146/76635
DOI:
10.1007/s00394-008-2005-z
PubMed ID:
18458833
Additional Links:
http://www.springerlink.com/content/341r86xk66lj4476/
Type:
Article
Language:
en
ISSN:
1436-6207
Sponsors:
This review was written as a part of the research integration in the Workpackage “Mechanisms of modulation of cancer by dietary factors” in the NoE Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS, no. 513943; www.ecnis.org). Additional support was obtained from the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, the Lund University Hospital, and the Påhlsson Foundation. We thank Dr. Gunilla Önning for helpful advice. Biomedical Nutrition is also a member of the EU NoE the European Nutrigenomics Organization (NuGO, no. 505944) which partly supported the study.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorGromadzinska, Jolantaen
dc.contributor.authorReszka, Edytaen
dc.contributor.authorBruzelius, Katharinaen
dc.contributor.authorWasowicz, Wojciechen
dc.contributor.authorAkesson, Bjornen
dc.date.accessioned2009-08-07T07:59:19Zen
dc.date.available2009-08-07T07:59:19Zen
dc.date.issued2008-05en
dc.identifier.citationEur. J. Nutr. 2008, 47 Suppl 2:29-50en
dc.identifier.issn1436-6207en
dc.identifier.pmid18458833en
dc.identifier.doi10.1007/s00394-008-2005-zen
dc.identifier.urihttp://hdl.handle.net/10146/76635en
dc.description.abstractBACKGROUND: The relationship between selenium and cancer involves many different aspects. These include the forms of selenium present in the diet and in the body, their functions and mechanisms of action, and methods employed in assessing an individual's selenium nutritional status-both in general, and in epidemiological studies of the risk of cancer in relation to diet, as well as in connection with long-term trials for investigating the disease-preventive potential of selenium supplementation. AIM OF THE REVIEW: To review different aspects on selenium metabolism, the occurrence of different selenoproteins and their use as biomarkers of selenium status, the results of intervention trials of the cancer-preventive effects of selenium supplementation, the mechanisms of action involved, together with epidemiological findings on relations between the selenium status in the body and risk of cancer. RESULTS AND CONCLUSIONS: The rapid advance in the knowledge of different selenoproteins and their biological functions has opened up new possibilities for the understanding of the biological effects of selenium supplementation. A wide variety of effects of different forms and doses of selenium has been observed in a number of experimental systems, and it is at present difficult to pinpoint the mechanism that may explain the positive preventive effects of selenium supplementation observed in some human long-term trials. Moreover, additional such trials are needed to define the benefits and risks of different types and doses of selenium supplements which in the future may be implemented for public health reasons. Another necessary focus for future research is a better understanding of the mechanisms by which selenium interferes with the carcinogenesis process.en
dc.description.sponsorshipThis review was written as a part of the research integration in the Workpackage “Mechanisms of modulation of cancer by dietary factors” in the NoE Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS, no. 513943; www.ecnis.org). Additional support was obtained from the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, the Lund University Hospital, and the Påhlsson Foundation. We thank Dr. Gunilla Önning for helpful advice. Biomedical Nutrition is also a member of the EU NoE the European Nutrigenomics Organization (NuGO, no. 505944) which partly supported the study.en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/341r86xk66lj4476/en
dc.subjectselenoproteinsen
dc.subjectforms of seleniumen
dc.subjectselenium status and cancer risken
dc.subjectcellular actions of seleniumen
dc.subjectchemopreventive effect of seleniumen
dc.subject.meshAntioxidantsen
dc.subject.meshBiological Markersen
dc.subject.meshDietary Supplementsen
dc.subject.meshHumansen
dc.subject.meshNeoplasmsen
dc.subject.meshNutritional Statusen
dc.subject.meshRisk Factorsen
dc.subject.meshSeleniumen
dc.subject.meshSelenoproteinsen
dc.titleSelenium and cancer: biomarkers of selenium status and molecular action of selenium supplements.en
dc.typeArticleen
dc.identifier.journalEuropean journal of nutritionen

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