Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure.

2.50
Hdl Handle:
http://hdl.handle.net/10146/76454
Title:
Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure.
Authors:
de Vocht, Frank; Burstyn, Igor; Ferro, Gilles; Olsson, Ann; Hashibe, Mia; Kromhout, Hans; Boffetta, Paolo
Abstract:
PURPOSE: A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations. METHODS: New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated. RESULTS: The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure. CONCLUSIONS: The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.
Citation:
Int. Arch. Occup. Environ. Health 2009, 82 (6):723-733
Journal:
International archives of occupational and environmental health
Issue Date:
May-2009
URI:
http://hdl.handle.net/10146/76454
DOI:
10.1007/s00420-008-0373-6
PubMed ID:
18956211
Additional Links:
http://www.springerlink.com/content/e0728722ht844630/
Type:
Article
Language:
en
ISSN:
1432-1246
Sponsors:
This study was sponsored by a training fellowship grant from the European Union Sixth Framework Programme Network of Excellence on Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS) (FOOD-CT-2005-513 943). The international component of the study was supported by share cost contracts from the European Commission (grant No. BMH4-CT95-1100) and EAPA, Eurobitume, and CONCAWE.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorde Vocht, Frank-
dc.contributor.authorBurstyn, Igor-
dc.contributor.authorFerro, Gilles-
dc.contributor.authorOlsson, Ann-
dc.contributor.authorHashibe, Mia-
dc.contributor.authorKromhout, Hans-
dc.contributor.authorBoffetta, Paolo-
dc.date.accessioned2009-08-06T07:57:36Z-
dc.date.available2009-08-06T07:57:36Z-
dc.date.issued2009-05-
dc.identifier.citationInt. Arch. Occup. Environ. Health 2009, 82 (6):723-733en
dc.identifier.issn1432-1246-
dc.identifier.pmid18956211-
dc.identifier.doi10.1007/s00420-008-0373-6-
dc.identifier.urihttp://hdl.handle.net/10146/76454-
dc.description.abstractPURPOSE: A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations. METHODS: New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated. RESULTS: The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure. CONCLUSIONS: The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.en
dc.description.sponsorshipThis study was sponsored by a training fellowship grant from the European Union Sixth Framework Programme Network of Excellence on Environmental Cancer risk, Nutrition and Individual Susceptibility (ECNIS) (FOOD-CT-2005-513 943). The international component of the study was supported by share cost contracts from the European Commission (grant No. BMH4-CT95-1100) and EAPA, Eurobitume, and CONCAWE.en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/e0728722ht844630/en
dc.subjectAsphalt industryen
dc.subjectAsphalt pavingen
dc.subjectExposure assessmenten
dc.subjectBitumen fumeen
dc.subjectSensitivity analysisen
dc.subject.meshAir Pollutants, Occupational-
dc.subject.meshCohort Studies-
dc.subject.meshFrance-
dc.subject.meshHumans-
dc.subject.meshHydrocarbons-
dc.subject.meshInhalation Exposure-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshOccupational Diseases-
dc.subject.meshOccupational Exposure-
dc.subject.meshRisk-
dc.titleSensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure.en
dc.typeArticleen
dc.identifier.journalInternational archives of occupational and environmental healthen

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