Mechanisms of combined action of different chemopreventive dietary compounds: a review.

2.50
Hdl Handle:
http://hdl.handle.net/10146/76433
Title:
Mechanisms of combined action of different chemopreventive dietary compounds: a review.
Authors:
de Kok, Theo M.; van Breda, Simone G.; Manson, Margaret M.
Abstract:
Consumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug-phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.
Citation:
Eur. J. Nutr. 2008, 47 Suppl 2:51-59
Journal:
European journal of nutrition
Issue Date:
May-2008
URI:
http://hdl.handle.net/10146/76433
DOI:
10.1007/s00394-008-2006-y
PubMed ID:
18458834
Additional Links:
http://www.springerlink.com/content/t07k43lv73323137/
Type:
Article
Language:
en
ISSN:
1436-6207
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorde Kok, Theo M.-
dc.contributor.authorvan Breda, Simone G.-
dc.contributor.authorManson, Margaret M.-
dc.date.accessioned2009-08-06T07:54:06Z-
dc.date.available2009-08-06T07:54:06Z-
dc.date.issued2008-05-
dc.identifier.citationEur. J. Nutr. 2008, 47 Suppl 2:51-59en
dc.identifier.issn1436-6207-
dc.identifier.pmid18458834-
dc.identifier.doi10.1007/s00394-008-2006-y-
dc.identifier.urihttp://hdl.handle.net/10146/76433-
dc.description.abstractConsumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug-phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/t07k43lv73323137/en
dc.subjectchemopreventionen
dc.subjectphytochemicalsen
dc.subjectsynergistic effectsen
dc.subjectpolyphenolsen
dc.subjectvegetablesen
dc.subject.meshAnticarcinogenic Agents-
dc.subject.meshChemoprevention-
dc.subject.meshDrug Synergism-
dc.subject.meshFlavonoids-
dc.subject.meshFruit-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshPhenols-
dc.subject.meshPlant Extracts-
dc.subject.meshVegetables-
dc.titleMechanisms of combined action of different chemopreventive dietary compounds: a review.en
dc.typeArticleen
dc.identifier.journalEuropean journal of nutritionen

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