Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).

2.50
Hdl Handle:
http://hdl.handle.net/10146/76316
Title:
Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).
Authors:
Crusius, J.B.A.; Canzian, F.; Capella, G.; Pena, A .S.; Pera, G.; Sala, N.; Agudo, A..; Rico, F.; Del Giudice, G.; Palli, D.; Plebani, M.; Boeing, H.; Bueno-de-Mesquita, H.B.; Carneiro, F.; Pala, V.; Save, V.E.; Vineis, P.; Tumino, R.; Panico, S.; Berglund, G.; Manjer, J.; Stenling, R.; Hallmans, G.; Martinez, C.; Dorronsoro, M.; Barricarte, A.; Navarro, C.; Quiros, J.R.; Allen, N.; Key, T.J.; Binghan, S; Caldas, C..; Linseisen, J.; Kaaks, R.; Overvad, K.; Tjonneland, A.; Bchner, F.C.; Peeters, P.H.M.; Numans, M.E.; Clavel-Chapelon, F.; Trichopoulou, A.; Lund, E; Jenab, M.; Rinaldi, S..; Ferrari, P.; Riboli, E.; Gonzáalez, C.A.
Abstract:
BACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. RESULTS: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). CONCLUSION: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.
Citation:
Ann. Oncol. 2008, 19 (11):1894-1902
Journal:
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Issue Date:
Nov-2008
URI:
http://hdl.handle.net/10146/76316
DOI:
10.1093/annonc/mdn400
PubMed ID:
18628242
Additional Links:
http://annonc.oxfordjournals.org/cgi/content/full/19/11/1894
Type:
Article
Language:
en
ISSN:
1569-8041
Sponsors:
Some authors are partners of ECNIS, a network of excellence of the EC (FP6 contract 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorCrusius, J.B.A.-
dc.contributor.authorCanzian, F.-
dc.contributor.authorCapella, G.-
dc.contributor.authorPena, A .S.-
dc.contributor.authorPera, G.-
dc.contributor.authorSala, N.-
dc.contributor.authorAgudo, A..-
dc.contributor.authorRico, F.-
dc.contributor.authorDel Giudice, G.-
dc.contributor.authorPalli, D.-
dc.contributor.authorPlebani, M.-
dc.contributor.authorBoeing, H.-
dc.contributor.authorBueno-de-Mesquita, H.B.-
dc.contributor.authorCarneiro, F.-
dc.contributor.authorPala, V.-
dc.contributor.authorSave, V.E.-
dc.contributor.authorVineis, P.-
dc.contributor.authorTumino, R.-
dc.contributor.authorPanico, S.-
dc.contributor.authorBerglund, G.-
dc.contributor.authorManjer, J.-
dc.contributor.authorStenling, R.-
dc.contributor.authorHallmans, G.-
dc.contributor.authorMartinez, C.-
dc.contributor.authorDorronsoro, M.-
dc.contributor.authorBarricarte, A.-
dc.contributor.authorNavarro, C.-
dc.contributor.authorQuiros, J.R.-
dc.contributor.authorAllen, N.-
dc.contributor.authorKey, T.J.-
dc.contributor.authorBinghan, S-
dc.contributor.authorCaldas, C..-
dc.contributor.authorLinseisen, J.-
dc.contributor.authorKaaks, R.-
dc.contributor.authorOvervad, K.-
dc.contributor.authorTjonneland, A.-
dc.contributor.authorBchner, F.C.-
dc.contributor.authorPeeters, P.H.M.-
dc.contributor.authorNumans, M.E.-
dc.contributor.authorClavel-Chapelon, F.-
dc.contributor.authorTrichopoulou, A.-
dc.contributor.authorLund, E-
dc.contributor.authorJenab, M.-
dc.contributor.authorRinaldi, S..-
dc.contributor.authorFerrari, P.-
dc.contributor.authorRiboli, E.-
dc.contributor.authorGonzáalez, C.A.-
dc.date.accessioned2009-08-05T07:54:25Z-
dc.date.available2009-08-05T07:54:25Z-
dc.date.issued2008-11-
dc.identifier.citationAnn. Oncol. 2008, 19 (11):1894-1902en
dc.identifier.issn1569-8041-
dc.identifier.pmid18628242-
dc.identifier.doi10.1093/annonc/mdn400-
dc.identifier.urihttp://hdl.handle.net/10146/76316-
dc.description.abstractBACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. RESULTS: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). CONCLUSION: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.en
dc.description.sponsorshipSome authors are partners of ECNIS, a network of excellence of the EC (FP6 contract 513943).en
dc.language.isoenen
dc.relation.urlhttp://annonc.oxfordjournals.org/cgi/content/full/19/11/1894en
dc.subjectAdenocarcinomaen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectInterleukinsen
dc.subjectNutritional Statusen
dc.subjectStomach Neoplasmsen
dc.subjectTumor Necrosis Factor-alphaen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCase-Control Studies-
dc.subject.meshCytokines-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenotype-
dc.subject.meshHaplotypes-
dc.subject.meshHumans-
dc.subject.meshInterleukins-
dc.subject.meshLymphotoxin-alpha-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNutritional Status-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshProspective Studies-
dc.subject.meshStomach Neoplasms-
dc.subject.meshTumor Necrosis Factor-alpha-
dc.titleCytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).en
dc.typeArticleen
dc.identifier.journalAnnals of oncology : official journal of the European Society for Medical Oncology / ESMOen

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