DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study.

2.50
Hdl Handle:
http://hdl.handle.net/10146/76314
Title:
DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study.
Authors:
Capella, Gabriel; Pera, Guillem; Sala, Nuria; Agudo, Antonio; Rico, Francisco; Del Giudicce, Giuseppe; Plebani, Mario; Palli, Domenico; Boeing, Heiner; Bueno-de-Mesquita, H. Bas; Carneiro, Fatima; Berrino, Franco; Vineis, Paolo; Tumino, Rosario; Panico, Salvatore; Berglund, Goran; Siman, Henrik; Nyren, Olof; Hallmans, Goran; Martinez, Carmen; Dorronsoro, Miren; Barricarte, Aurelio; Navarro, Carmen; Quirós, Jose R.; Allen, Naomi; Key, Tim; Bingham, Sheila; Caldas, Carlos; Linseisen, Jakob; Nagel, Gabriele; Overvad, Kim; Tjonneland, Anne; Boshuizen, Hendriek C.; Peeters, Petra H.M.; Numans, Mattijs E.; Clavel-Chapelon, Francoise; Trichopoulou, Antonia; Lund, Eiliv; Jenab, Mazda; Kaaks, Rudolf; Riboli, Elio; Gonzalez, Carlos A.
Abstract:
BACKGROUND: The contribution of genetic variation in DNA repair genes to gastric cancer (GC) risk remains essentially unknown. The aim of this study was to explore the relative contribution of DNA repair gene polymorphisms to GC risk and severe chronic atrophic gastritis (SCAG). Method A nested case control study within the EPIC cohort was performed including 246 gastric adenocarcinomas and 1175 matched controls. Controls with SCAG (n = 91), as defined by low pepsinogen A (PGA) levels, and controls with no SCAG (n = 1061) were also compared. Twelve polymorphisms at DNA repair genes (MSH2, MLH1, XRCC1, OGG1 and ERCC2) and TP53 gene were analysed. Antibodies against Helicobacter pylori were measured. RESULTS: No association was observed for any of these polymorphisms with stomach cancer risk. However, ERCC2 K751Q polymorphism was associated with an increased risk for non-cardial neoplasm [odds ratio (OR) = 1.78; 95% confidence interval (CI) 1.02-3.12], being ERCC2 K751Q and D312N polymorphisms associated with the diffuse type. ERCC2 D312N (OR = 2.0; 95% CI 1.09-3.65) and K751Q alleles (OR = 1.82; 95% CI 1.01-3.30) and XRCC1 R399Q (OR = 1.69; 95% CI 1.02-2.79) allele were associated with an increased risk for SCAG. CONCLUSION: Our study supports a role of ERCC2 in non-cardial GC but not in cardial cancer. A concordant result was observed for subjects with low PGA levels. XRCC1 allele was associated also with SCAG. This is the first prospective study suggesting that individual variation in DNA repair may be relevant for gastric carcinogenesis, a finding that will require further confirmation validation in larger independent studies.
Citation:
Int. J. Epidemiol. 2008, 37 (6):1316-1325
Journal:
International journal of epidemiology
Issue Date:
Dec-2008
URI:
http://hdl.handle.net/10146/76314
DOI:
10.1093/ije/dyn145
PubMed ID:
18641418
Additional Links:
http://ije.oxfordjournals.org/cgi/content/full/37/6/1316
Type:
Article
Language:
en
ISSN:
1464-3685
Sponsors:
Some authors are partners of ECNIS Network from the 6FP of the EC.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorCapella, Gabriel-
dc.contributor.authorPera, Guillem-
dc.contributor.authorSala, Nuria-
dc.contributor.authorAgudo, Antonio-
dc.contributor.authorRico, Francisco-
dc.contributor.authorDel Giudicce, Giuseppe-
dc.contributor.authorPlebani, Mario-
dc.contributor.authorPalli, Domenico-
dc.contributor.authorBoeing, Heiner-
dc.contributor.authorBueno-de-Mesquita, H. Bas-
dc.contributor.authorCarneiro, Fatima-
dc.contributor.authorBerrino, Franco-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorTumino, Rosario-
dc.contributor.authorPanico, Salvatore-
dc.contributor.authorBerglund, Goran-
dc.contributor.authorSiman, Henrik-
dc.contributor.authorNyren, Olof-
dc.contributor.authorHallmans, Goran-
dc.contributor.authorMartinez, Carmen-
dc.contributor.authorDorronsoro, Miren-
dc.contributor.authorBarricarte, Aurelio-
dc.contributor.authorNavarro, Carmen-
dc.contributor.authorQuirós, Jose R.-
dc.contributor.authorAllen, Naomi-
dc.contributor.authorKey, Tim-
dc.contributor.authorBingham, Sheila-
dc.contributor.authorCaldas, Carlos-
dc.contributor.authorLinseisen, Jakob-
dc.contributor.authorNagel, Gabriele-
dc.contributor.authorOvervad, Kim-
dc.contributor.authorTjonneland, Anne-
dc.contributor.authorBoshuizen, Hendriek C.-
dc.contributor.authorPeeters, Petra H.M.-
dc.contributor.authorNumans, Mattijs E.-
dc.contributor.authorClavel-Chapelon, Francoise-
dc.contributor.authorTrichopoulou, Antonia-
dc.contributor.authorLund, Eiliv-
dc.contributor.authorJenab, Mazda-
dc.contributor.authorKaaks, Rudolf-
dc.contributor.authorRiboli, Elio-
dc.contributor.authorGonzalez, Carlos A.-
dc.date.accessioned2009-08-05T07:26:20Z-
dc.date.available2009-08-05T07:26:20Z-
dc.date.issued2008-12-
dc.identifier.citationInt. J. Epidemiol. 2008, 37 (6):1316-1325en
dc.identifier.issn1464-3685-
dc.identifier.pmid18641418-
dc.identifier.doi10.1093/ije/dyn145-
dc.identifier.urihttp://hdl.handle.net/10146/76314-
dc.description.abstractBACKGROUND: The contribution of genetic variation in DNA repair genes to gastric cancer (GC) risk remains essentially unknown. The aim of this study was to explore the relative contribution of DNA repair gene polymorphisms to GC risk and severe chronic atrophic gastritis (SCAG). Method A nested case control study within the EPIC cohort was performed including 246 gastric adenocarcinomas and 1175 matched controls. Controls with SCAG (n = 91), as defined by low pepsinogen A (PGA) levels, and controls with no SCAG (n = 1061) were also compared. Twelve polymorphisms at DNA repair genes (MSH2, MLH1, XRCC1, OGG1 and ERCC2) and TP53 gene were analysed. Antibodies against Helicobacter pylori were measured. RESULTS: No association was observed for any of these polymorphisms with stomach cancer risk. However, ERCC2 K751Q polymorphism was associated with an increased risk for non-cardial neoplasm [odds ratio (OR) = 1.78; 95% confidence interval (CI) 1.02-3.12], being ERCC2 K751Q and D312N polymorphisms associated with the diffuse type. ERCC2 D312N (OR = 2.0; 95% CI 1.09-3.65) and K751Q alleles (OR = 1.82; 95% CI 1.01-3.30) and XRCC1 R399Q (OR = 1.69; 95% CI 1.02-2.79) allele were associated with an increased risk for SCAG. CONCLUSION: Our study supports a role of ERCC2 in non-cardial GC but not in cardial cancer. A concordant result was observed for subjects with low PGA levels. XRCC1 allele was associated also with SCAG. This is the first prospective study suggesting that individual variation in DNA repair may be relevant for gastric carcinogenesis, a finding that will require further confirmation validation in larger independent studies.en
dc.description.sponsorshipSome authors are partners of ECNIS Network from the 6FP of the EC.en
dc.language.isoenen
dc.relation.urlhttp://ije.oxfordjournals.org/cgi/content/full/37/6/1316en
dc.subjectGastric carcinomaen
dc.subjectDNA repairen
dc.subjectpolymorphismen
dc.subjectgenetic susceptibilityen
dc.subjectH. pylorien
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntibodies, Bacterial-
dc.subject.meshBiological Markers-
dc.subject.meshCardia-
dc.subject.meshCase-Control Studies-
dc.subject.meshChronic Disease-
dc.subject.meshDNA Repair-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGastritis, Atrophic-
dc.subject.meshGene Frequency-
dc.subject.meshGenes, p53-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHelicobacter Infections-
dc.subject.meshHelicobacter pylori-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshOdds Ratio-
dc.subject.meshPepsinogen A-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshProspective Studies-
dc.subject.meshRisk-
dc.subject.meshStomach Neoplasms-
dc.subject.meshXeroderma Pigmentosum Group D Protein-
dc.titleDNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study.en
dc.typeArticleen
dc.identifier.journalInternational journal of epidemiologyen

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