Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals.

2.50
Hdl Handle:
http://hdl.handle.net/10146/76197
Title:
Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals.
Authors:
Brauner, Elvira V.; Moller, Peter; Barregard, Lars; Dragsted, Lars O.; Glasius, Marianne; Wahlin, Peter; Vinzents, Peter; Raaschou-Nielsen, Ole; Loft, Steffen
Abstract:
ABSTRACT: BACKGROUND: Particulate air pollution is associated with increased risk of cardiovascular events although the involved mechanisms are poorly understood. The objective of the present study was to investigate the effects of controlled exposure to ambient air fine and ultrafine particles on microvascular function and biomarkers related to inflammation, haemostasis and lipid and protein oxidation. METHODS: Twenty-nine subjects participated in a randomized, two-factor crossover study with or without biking exercise for 180 minutes and with 24 hour exposure to particle rich (number concentrations, NC: 11600 +/- 5600 per cm3, mass concentrations: 13.8 +/- 7.4 mug/m3 and 10.5 +/- 4.8 mug/m3 for PM10-2.5 and PM2.5, respectively) or particle filtered (NC: 555 +/- 1053 per cm3) air collected above a busy street. Microvascular function was assessed non-invasively by measuring digital peripheral artery tone following arm ischemia. Biomarkers included haemoglobin, red blood cells, platelet count, coagulation factors, C-reactive protein, fibrinogen, interleukin-6, tumour necrosis factor alpha, lag time to copper-induced oxidation of plasma lipids and protein oxidation measured as 2-aminoadipic semialdehyde in plasma. RESULTS: No statistically significant differences were observed on microvascular function or the biomarkers after exposure to particle rich or particle filtered air. CONCLUSION: This study indicates that exposure to air pollution particles at outdoor concentrations is not associated with detectable systemic inflammation, lipid or protein oxidation, altered haemostasis or microvascular function in young healthy participants.
Citation:
Part .Fibre Toxicol. 2008, 5:13
Journal:
Particle and fibre toxicology
Issue Date:
2008
URI:
http://hdl.handle.net/10146/76197
DOI:
10.1186/1743-8977-5-13
PubMed ID:
18837984
Additional Links:
http://www.particleandfibretoxicology.com/content/5/1/13; http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18837984
Type:
Article
Language:
en
ISSN:
1743-8977
Sponsors:
This work was supported by the Danish National Research Councils and ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: "Food Quality and Safety" (Contract No 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorBrauner, Elvira V.-
dc.contributor.authorMoller, Peter-
dc.contributor.authorBarregard, Lars-
dc.contributor.authorDragsted, Lars O.-
dc.contributor.authorGlasius, Marianne-
dc.contributor.authorWahlin, Peter-
dc.contributor.authorVinzents, Peter-
dc.contributor.authorRaaschou-Nielsen, Ole-
dc.contributor.authorLoft, Steffen-
dc.date.accessioned2009-08-04T08:34:23Z-
dc.date.available2009-08-04T08:34:23Z-
dc.date.issued2008-
dc.identifier.citationPart .Fibre Toxicol. 2008, 5:13en
dc.identifier.issn1743-8977-
dc.identifier.pmid18837984-
dc.identifier.doi10.1186/1743-8977-5-13-
dc.identifier.urihttp://hdl.handle.net/10146/76197-
dc.description.abstractABSTRACT: BACKGROUND: Particulate air pollution is associated with increased risk of cardiovascular events although the involved mechanisms are poorly understood. The objective of the present study was to investigate the effects of controlled exposure to ambient air fine and ultrafine particles on microvascular function and biomarkers related to inflammation, haemostasis and lipid and protein oxidation. METHODS: Twenty-nine subjects participated in a randomized, two-factor crossover study with or without biking exercise for 180 minutes and with 24 hour exposure to particle rich (number concentrations, NC: 11600 +/- 5600 per cm3, mass concentrations: 13.8 +/- 7.4 mug/m3 and 10.5 +/- 4.8 mug/m3 for PM10-2.5 and PM2.5, respectively) or particle filtered (NC: 555 +/- 1053 per cm3) air collected above a busy street. Microvascular function was assessed non-invasively by measuring digital peripheral artery tone following arm ischemia. Biomarkers included haemoglobin, red blood cells, platelet count, coagulation factors, C-reactive protein, fibrinogen, interleukin-6, tumour necrosis factor alpha, lag time to copper-induced oxidation of plasma lipids and protein oxidation measured as 2-aminoadipic semialdehyde in plasma. RESULTS: No statistically significant differences were observed on microvascular function or the biomarkers after exposure to particle rich or particle filtered air. CONCLUSION: This study indicates that exposure to air pollution particles at outdoor concentrations is not associated with detectable systemic inflammation, lipid or protein oxidation, altered haemostasis or microvascular function in young healthy participants.en
dc.description.sponsorshipThis work was supported by the Danish National Research Councils and ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: "Food Quality and Safety" (Contract No 513943).en
dc.language.isoenen
dc.relation.urlhttp://www.particleandfibretoxicology.com/content/5/1/13en
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18837984en
dc.titleExposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals.en
dc.typeArticleen
dc.identifier.journalParticle and fibre toxicologyen

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