Search:
Browse by
Collection All
bullet
bullet
bullet
bullet
bullet
bullet
Listed communities
bullet
bullet

ECNIS Repository > ECNIS annotated biomarkers bibliographic database - test version > Articles with annotation > Solar cycles and their relationship to human disease and adaptability.

Please use this identifier to cite or link to this item: http://hdl.handle.net/10146/69694
    Del.icio.us     Citeulike     Connotea     Facebook     Stumble it!


Title: Solar cycles and their relationship to human disease and adaptability.
Authors: Davis, George E.
Lowell, Walter E.
Citation: Med. Hypotheses 2006, 67 (3):447-461
Journal : Medical hypotheses
Issue date: 2006
URI: http://hdl.handle.net/10146/69694
DOI: 10.1016/j.mehy.2006.03.011
PubMed ID: 16701959
Additional Links: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WN2-4JYKM11-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=59afe79a12a3894b4e259a4f042cd05d
http://www.medical-hypotheses.com/article/S0306-9877(06)00182-4/abstract
Abstract: In this paper, we show that 11-year solar cycle peaks predispose humans to disease, but also endow creativity and adaptability. We give several examples of diseases that are modulated by light and present evidence for an effect of intensity and variation in sunlight, primarily ultraviolet radiation (UVR), on the human genome. The birth dates of nearly 237,000 unique clients in the Maine Medicaid database collected from 1995 to 2004, inclusive, were related to solar cycle irradiance for the past seventy-one years, encompassing seven solar cycles. The sample was divided into four general categories of disease: mental/behavioral illnesses; metabolic diseases; autoimmune diseases; neoplasms. The birth months for those clients born in any given year were arranged in the form of a winter/summer ratio in order to more clearly appreciate the seasonality inherent in each disease category. Solar cycles were separated into chaotic (approximately three times as irradiant) or non-chaotic according to the Gutenberg-Richter power law and the uncertainty inherent in predicting solar storms. The results show that radiation peaks in solar cycles and particularly in chaotic solar cycles (CSCs) are associated with a higher incidence of mental disorders, suggesting the sensitivity of ectodermal embryonic tissues to UVR. Autoimmune diseases have intermediate sensitivity, while the neoplasms in the study, primarily of endoderm, appear suppressed by peak UVR intensity. The ratio of the number of clients born in CSC cycles to non-CSC cycles was highest for the more genetic mental diseases, like schizophrenia and bipolar disorder, but as that ratio decreased, the clients with diseases like multiple sclerosis and rheumatoid arthritis showed more environmental features manifested as a greater winter/summer birth month ratio that was significantly different than that of the average client in the whole data set. The paper presents evidence that latitude, e.g., variation in light, is an added stress to the immune system (especially at 53-54 degrees N. latitude) that is involved in nearly all human disease. We hypothesize that introns, the presumptive engenderers of gene control, modulate the effects of UVR, particularly for the neoplasms studied. We conclude that intermittent and largely unpredictable peak solar cycle radiation has been the fundamental engine of evolution, forcing organisms to adapt to mutagenic UVR and producing enough damage to instigate genetic variation. Probably a chance genetic mutation over 80,000 years ago produced a human brain capable of abstract thought and consciousness. The slight genetic instability that favored an adaptable, creative brain also produced other somatic variations that present phenotypically as disease, but largely expressed after natural selection (reproduction) and associated with the inexorable entropy of aging.
Type: Article
Language: en
Description: Cancer type: breast cancer; lung cancer; brain neoplasm; leukemia; prostate cancer; colon cancer. Study design: cohort study. Description of cohort(s) studied: Birth date (month, year of birth), gender and diagnosis data were collected from the Maine Medicaid database from 1995 to 2004, inclusive and comprised of 236,962 unique clients/patients across 37 categories of disease. Clients usually had more than one disease, with an average of 2.2 diseases per client.Exposure(s) evaluated: intensity and variation in sunlight, primarily ultraviolet radiation (UVR)Dose-response: The results show that radiation peaks in solar cycles and particularly in chaotic solar cycles (CSCs) are associated with a higher incidence of mental disorders, suggesting the sensitivity of ectodermal embryonic tissues to UVR. Autoimmune diseases have intermediate sensitivity, while the neoplasms in the study, primarily of endoderm, appear suppressed by peak UVR intensity. The ratio of the number of clients born in CSC cycles to non-CSC cycles was highest for the more genetic mental diseases, like schizophrenia and bipolar disorder, but as that ratio decreased, the clients with diseases like multiple sclerosis and rheumatoid arthritis showed more environmental features manifested as a greater winter/summer birth month ratio that was significantly different than that of the average client in the whole data set. KEYWORD CLASSIFICATION: Adaptation,Physiological;analysis;Autoimmune Diseases;cancer epidemiology;classification;Databases,Factual;diagnosis;Disease;epidemiology;etiology;Evaluation;Female;genetic;Genome,Human;Humans;immunology;Incidence;Male;Melanoma;Mental Disorders;Metabolic Diseases;Models,Biological;Neoplasms;pathology;radiation effects;Registries;Research;Retrospective Studies;Seasons;Solar Activity;Ultraviolet Rays;
MeSH: Adaptation, Physiological
Autoimmune Diseases
Databases, Factual
Disease
Female
Genome, Human
Humans
Incidence
Male
Mental Disorders
Metabolic Diseases
Models, Biological
Neoplasms
Registries
Retrospective Studies
Seasons
Solar Activity
Ultraviolet Rays
ISSN: 0306-9877
Appears in collections:Articles with annotation

Files in this item:

There are no files associated with this item.



Related articles on PubMed
bullet
bullet
bullet
Chronoastrobiology: proposal, nine conferences, heliogeomagnetics, transyears, near-weeks, near-decades, phylogenetic and ontogenetic memories.
Halberg F, Cornélissen G, Regal P, Otsuka K, Wang Z, Katinas GS, Siegelova J, Homolka P, Prikryl P, Chibisov SM, Holley DC, Wendt HW, Bingham C, Palm SL, Sonkowsky RP, Sothern RB, Pales E, Mikulecky M, Tarquini R, Perfetto F, Salti R, Maggioni C, Jozsa R, Konradov AA, Kharlitskaya EV, Revillam M, Wan C, Herold M, Syutkina EV, Masalov AV, Faraone P, Singh RB, Singh RK, Kumar A, Singhs R, Sundaram S, Sarabandi T, Pantaleoni G, Watanabe Y, Kumagai Y, Gubin D, Uezono K, Olah A, Borer K, Kanabrockia EA, Bathina S, Haus E, Hillman D, Schwartzkopff O, Bakken EE, Zeman M
2004 Oct
bullet
bullet
See all 340 articles

All items in ECNIS are protected by copyright, with all rights reserved, unless otherwise indicated.

 

OR Logo Powered by Open Repository
Valid XHTML 1.0!