Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene.

2.50
Hdl Handle:
http://hdl.handle.net/10146/68614
Title:
Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene.
Authors:
Yu, Zhen; Mahadevan, Brinda; Lohr, Christiane V.; Fischer, Kay A.; Louderback, Mandy A.; Krueger, Sharon K.; Pereira, Clifford B.; Albershardt, Daniel J.; Baird, William M.; Bailey, George S.; Williams, David E.
Abstract:
The fetus and neonate are sensitive targets for chemically induced carcinogenesis. Few studies have examined the risk/benefit of chemoprotective phytochemicals, given in the maternal diet, against transplacental carcinogenesis. In this study, B6129 SF1/J (AHR(b-1/d)) and 129Sv/ImJ (AHR(d/d)) mice were cross-bred. The polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/kg, gavage) on gestation day 17, and 2000 p.p.m. indole-3-carbinol (I3C), a chemoprotective phytochemical from cruciferous vegetables, was fed to half of the mice from gestation day 9 until weaning. Offspring born to dams fed I3C exhibited markedly fewer mortalities (P < 0.0001). Maternal dietary exposure to I3C also significantly lowered lung tumor multiplicity (P = 0.035) in offspring surviving to 10 months of age. The I3C chemoprotection was independent of either maternal or fetal AHR genotype. The bioavailability of DBP to fetal target tissue was demonstrated by assessing DNA covalent adduction with a (33)P-post-labeling assay. The bioavailability of I3C was determined by dosing a subset of pregnant mice with [(14)C]-I3C. Addition of chemoprotective agents to the maternal diet during pregnancy and nursing may be an effective new approach in reducing the incidence of cancers in children and young adults.
Citation:
Carcinogenesis 2006, 27 (10):2116-2123
Journal:
Carcinogenesis
Issue Date:
Oct-2006
URI:
http://hdl.handle.net/10146/68614
DOI:
10.1093/carcin/bgl072
PubMed ID:
16704990
Additional Links:
http://carcin.oxfordjournals.org/cgi/content/full/27/10/2116
Type:
Article
Language:
en
Description:
Dietary modulation of cancer & cancer biomarkers. Dietary item or component studied: indole-3-carbinol (I3C)Outcome studied: lung tumor multiplicity. Study type: mice resulting from reciprocal crosses between B6129 SF1/J [AHR(b-1/d)] and 129Sv/ImJ [AHR(d/d)] mice. Tissue/biological material/sample size: heart, thymus, lung, spleen, liver, kidney, abnormal lymph node, testes or ovaries, colon and skinMode of exposure: dibenzo[a,l]pyrene (DBP) was administered to pregnant mice (15 mg/kg, gavage) on gestation day 17, and 2000 p.p.m. indole-3-carbinol (I3C) was fed to half of the mice from gestation day 9 until weaning. Impact on outcome (including dose-response): Offspring born to dams fed I3C exhibited markedly fewer mortalities (P < 0.0001). Maternal dietary exposure to I3C also significantly lowered lung tumor multiplicity (P = 0.035) in offspring surviving to 10 months of age. The I3C chemoprotection was independent of either maternal or fetal AHR genotype. The bioavailability of DBP to fetal target tissue was demonstrated by assessing DNA covalent adduction with a (33)P-post-labeling assay. The bioavailability of I3C was determined by dosing a subset of pregnant mice with [(14)C]-I3C. KEYWORD CLASSIFICATION: administration & dosage;analysis;Animals;antagonists & inhibitors;Anticarcinogenic Agents;Benzopyrenes;Biological Availability;chemically induced;Diet;dietary modulation of cancer & cancer biomarkers;DNA Adducts;Female;Fetal Diseases;humans;Indoles;Liver Neoplasms,Experimental;Lung;Lung Neoplasms;Lymphoma;Male;Maternal-Fetal Exchange;metabolism;Mice;mortality;NF-kappa B;nursing;pharmacokinetics;Pregnancy;prevention & control;Research;toxicity;Toxicology;
ISSN:
0143-3334
Appears in Collections:
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Full metadata record

DC FieldValue Language
dc.contributor.authorYu, Zhen-
dc.contributor.authorMahadevan, Brinda-
dc.contributor.authorLohr, Christiane V.-
dc.contributor.authorFischer, Kay A.-
dc.contributor.authorLouderback, Mandy A.-
dc.contributor.authorKrueger, Sharon K.-
dc.contributor.authorPereira, Clifford B.-
dc.contributor.authorAlbershardt, Daniel J.-
dc.contributor.authorBaird, William M.-
dc.contributor.authorBailey, George S.-
dc.contributor.authorWilliams, David E.-
dc.date.accessioned2009-05-20T07:45:12Z-
dc.date.available2009-05-20T07:45:12Z-
dc.date.issued2006-10-
dc.identifier.citationCarcinogenesis 2006, 27 (10):2116-2123en
dc.identifier.issn0143-3334-
dc.identifier.pmid16704990-
dc.identifier.doi10.1093/carcin/bgl072-
dc.identifier.urihttp://hdl.handle.net/10146/68614-
dc.descriptionDietary modulation of cancer & cancer biomarkers. Dietary item or component studied: indole-3-carbinol (I3C)Outcome studied: lung tumor multiplicity. Study type: mice resulting from reciprocal crosses between B6129 SF1/J [AHR(b-1/d)] and 129Sv/ImJ [AHR(d/d)] mice. Tissue/biological material/sample size: heart, thymus, lung, spleen, liver, kidney, abnormal lymph node, testes or ovaries, colon and skinMode of exposure: dibenzo[a,l]pyrene (DBP) was administered to pregnant mice (15 mg/kg, gavage) on gestation day 17, and 2000 p.p.m. indole-3-carbinol (I3C) was fed to half of the mice from gestation day 9 until weaning. Impact on outcome (including dose-response): Offspring born to dams fed I3C exhibited markedly fewer mortalities (P < 0.0001). Maternal dietary exposure to I3C also significantly lowered lung tumor multiplicity (P = 0.035) in offspring surviving to 10 months of age. The I3C chemoprotection was independent of either maternal or fetal AHR genotype. The bioavailability of DBP to fetal target tissue was demonstrated by assessing DNA covalent adduction with a (33)P-post-labeling assay. The bioavailability of I3C was determined by dosing a subset of pregnant mice with [(14)C]-I3C. KEYWORD CLASSIFICATION: administration & dosage;analysis;Animals;antagonists & inhibitors;Anticarcinogenic Agents;Benzopyrenes;Biological Availability;chemically induced;Diet;dietary modulation of cancer & cancer biomarkers;DNA Adducts;Female;Fetal Diseases;humans;Indoles;Liver Neoplasms,Experimental;Lung;Lung Neoplasms;Lymphoma;Male;Maternal-Fetal Exchange;metabolism;Mice;mortality;NF-kappa B;nursing;pharmacokinetics;Pregnancy;prevention & control;Research;toxicity;Toxicology;en
dc.description.abstractThe fetus and neonate are sensitive targets for chemically induced carcinogenesis. Few studies have examined the risk/benefit of chemoprotective phytochemicals, given in the maternal diet, against transplacental carcinogenesis. In this study, B6129 SF1/J (AHR(b-1/d)) and 129Sv/ImJ (AHR(d/d)) mice were cross-bred. The polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/kg, gavage) on gestation day 17, and 2000 p.p.m. indole-3-carbinol (I3C), a chemoprotective phytochemical from cruciferous vegetables, was fed to half of the mice from gestation day 9 until weaning. Offspring born to dams fed I3C exhibited markedly fewer mortalities (P < 0.0001). Maternal dietary exposure to I3C also significantly lowered lung tumor multiplicity (P = 0.035) in offspring surviving to 10 months of age. The I3C chemoprotection was independent of either maternal or fetal AHR genotype. The bioavailability of DBP to fetal target tissue was demonstrated by assessing DNA covalent adduction with a (33)P-post-labeling assay. The bioavailability of I3C was determined by dosing a subset of pregnant mice with [(14)C]-I3C. Addition of chemoprotective agents to the maternal diet during pregnancy and nursing may be an effective new approach in reducing the incidence of cancers in children and young adults.en
dc.language.isoenen
dc.relation.urlhttp://carcin.oxfordjournals.org/cgi/content/full/27/10/2116en
dc.subject.meshAnimals-
dc.subject.meshAnticarcinogenic Agents-
dc.subject.meshBenzopyrenes-
dc.subject.meshBiological Availability-
dc.subject.meshDNA Adducts-
dc.subject.meshDiet-
dc.subject.meshFemale-
dc.subject.meshFetal Diseases-
dc.subject.meshIndoles-
dc.subject.meshLiver Neoplasms, Experimental-
dc.subject.meshLung-
dc.subject.meshLung Neoplasms-
dc.subject.meshLymphoma-
dc.subject.meshMale-
dc.subject.meshMaternal-Fetal Exchange-
dc.subject.meshMice-
dc.subject.meshNF-kappa B-
dc.subject.meshPregnancy-
dc.titleIndole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene.en
dc.typeArticleen
dc.identifier.journalCarcinogenesisen

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