HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation leukocytosis: A retrospective analysis on 53 transplant candidates (1989-2003).

2.50
Hdl Handle:
http://hdl.handle.net/10146/68537
Title:
HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation leukocytosis: A retrospective analysis on 53 transplant candidates (1989-2003).
Authors:
Ng, Margaret H.L.; Lau, K.M.; Hawkins, B.R.; Chik, K.W.; Chan, Natalie P.H.; Wong, W.S.; Tsang, K.S.; Shing, Matthew M.K.; Li, C.K.
Abstract:
We performed a retrospective analysis on the human leukocyte antigen (HLA) data of 53 consecutive Chinese patients with high-risk childhood acute lymphoblastic leukemia (ALL) diagnosed from 1989 to 2003. A significantly higher frequency of HLA-B67 in the male relapse group of patients [OR, 23.08; 95% CI, 5.31-100.36; p = 0.0042; for statistical significance after Bonferroni correction (Bc) p (Bc) < 0.0083] was identified after Bonferroni correction. Although not surviving the Bonferroni correction, gender effects on the association were also observed with HLA-A11, HLA-A32, HLA-A33, and HLA-B22, which were however more prevalent in the female patients and particularly those developing relapse. Two patients with HLA-A29 and HLA-B7 revealed significantly shortened survivals, suggestive of their potential prognostic impacts. Notably, for the first time, we found a significant correlation of leukocyte count with HLA types, where HLA-A33 (p = 0.006) or HLA-B17 (p < 0.001) signifies higher leukocytosis at presentation. Taken together, our findings support the involvement of HLA in Chinese high-risk childhood ALL.
Citation:
Ann. Hematol. 2006, 85 (8):535-541.
Journal:
Annals of Hematology
Issue Date:
Aug-2006
URI:
http://hdl.handle.net/10146/68537
DOI:
10.1007/s00277-006-0118-0
PubMed ID:
16710717
Additional Links:
http://www.springerlink.com/content/w2q01742820g519m/
Type:
Article
Language:
en
Description:
Biomarker: human leukocyte antigen HLA-B67. Effect studied: high-risk childhood acute lymphoblastic leukemia (ALL). Study type: humans Study design: nested case-control. Study size: 53 cases. Tissue/biological material/sample size: blood. Method of analysis: Serological typing was performed for Class I (HLA-A/HLA-B) up to 1996 and by moleculartechniques from 1997 onwards with comparable accuracy and concordance for all major A and B loci. Impact on outcome (including dose-response): A significantly higher frequency of HLA-B67 in the male relapse group of patients [OR, 23.08; 95% CI, 5.31-100.36; p = 0.0042; for statistical significance after Bonferroni correction (Bc) p (Bc) < 0.0083] was identified after Bonferroni correction. Although not surviving the Bonferroni correction, gender effects on the association were also observed with HLA-A11, HLA-A32, HLA-A33, and HLA-B22, which were however more prevalent in the female patients and particularly those developing relapse. Two patients with HLA-A29 and HLA-B7 revealed significantly shortened survivals, suggestive of their potential prognostic impacts. Notably, for the first time, we found a significant correlation of leukocyte count with HLA types, where HLA-A33 (p = 0.006) or HLA-B17 (p < 0.001) signifies higher leukocytosis at presentation. KEYWORD CLASSIFICATION: Adolescent;Adult;analysis;Asian Continental Ancestry Group;biomarkers of individual susceptibility: validation;blood;Child;Child,Preschool;China;diagnosis;Disease Susceptibility;Disease-Free Survival;Female;Follow-Up Studies;genetic;HLA-A Antigens;HLA-B Antigens;Hong Kong;Humans;Leukemia,Lymphocytic,Acute,L1;Leukocytosis;Male;mortality;Prognosis;Recurrence;Research;Retrospective Studies;Sex Characteristics;transplantation;Tumor Markers,Biological;validation;Wales;
ISSN:
0939-5555
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorNg, Margaret H.L.-
dc.contributor.authorLau, K.M.-
dc.contributor.authorHawkins, B.R.-
dc.contributor.authorChik, K.W.-
dc.contributor.authorChan, Natalie P.H.-
dc.contributor.authorWong, W.S.-
dc.contributor.authorTsang, K.S.-
dc.contributor.authorShing, Matthew M.K.-
dc.contributor.authorLi, C.K.-
dc.date.accessioned2009-05-19T08:35:51Z-
dc.date.available2009-05-19T08:35:51Z-
dc.date.issued2006-08-
dc.identifier.citationAnn. Hematol. 2006, 85 (8):535-541.en
dc.identifier.issn0939-5555-
dc.identifier.pmid16710717-
dc.identifier.doi10.1007/s00277-006-0118-0-
dc.identifier.urihttp://hdl.handle.net/10146/68537-
dc.descriptionBiomarker: human leukocyte antigen HLA-B67. Effect studied: high-risk childhood acute lymphoblastic leukemia (ALL). Study type: humans Study design: nested case-control. Study size: 53 cases. Tissue/biological material/sample size: blood. Method of analysis: Serological typing was performed for Class I (HLA-A/HLA-B) up to 1996 and by moleculartechniques from 1997 onwards with comparable accuracy and concordance for all major A and B loci. Impact on outcome (including dose-response): A significantly higher frequency of HLA-B67 in the male relapse group of patients [OR, 23.08; 95% CI, 5.31-100.36; p = 0.0042; for statistical significance after Bonferroni correction (Bc) p (Bc) < 0.0083] was identified after Bonferroni correction. Although not surviving the Bonferroni correction, gender effects on the association were also observed with HLA-A11, HLA-A32, HLA-A33, and HLA-B22, which were however more prevalent in the female patients and particularly those developing relapse. Two patients with HLA-A29 and HLA-B7 revealed significantly shortened survivals, suggestive of their potential prognostic impacts. Notably, for the first time, we found a significant correlation of leukocyte count with HLA types, where HLA-A33 (p = 0.006) or HLA-B17 (p < 0.001) signifies higher leukocytosis at presentation. KEYWORD CLASSIFICATION: Adolescent;Adult;analysis;Asian Continental Ancestry Group;biomarkers of individual susceptibility: validation;blood;Child;Child,Preschool;China;diagnosis;Disease Susceptibility;Disease-Free Survival;Female;Follow-Up Studies;genetic;HLA-A Antigens;HLA-B Antigens;Hong Kong;Humans;Leukemia,Lymphocytic,Acute,L1;Leukocytosis;Male;mortality;Prognosis;Recurrence;Research;Retrospective Studies;Sex Characteristics;transplantation;Tumor Markers,Biological;validation;Wales;en
dc.description.abstractWe performed a retrospective analysis on the human leukocyte antigen (HLA) data of 53 consecutive Chinese patients with high-risk childhood acute lymphoblastic leukemia (ALL) diagnosed from 1989 to 2003. A significantly higher frequency of HLA-B67 in the male relapse group of patients [OR, 23.08; 95% CI, 5.31-100.36; p = 0.0042; for statistical significance after Bonferroni correction (Bc) p (Bc) < 0.0083] was identified after Bonferroni correction. Although not surviving the Bonferroni correction, gender effects on the association were also observed with HLA-A11, HLA-A32, HLA-A33, and HLA-B22, which were however more prevalent in the female patients and particularly those developing relapse. Two patients with HLA-A29 and HLA-B7 revealed significantly shortened survivals, suggestive of their potential prognostic impacts. Notably, for the first time, we found a significant correlation of leukocyte count with HLA types, where HLA-A33 (p = 0.006) or HLA-B17 (p < 0.001) signifies higher leukocytosis at presentation. Taken together, our findings support the involvement of HLA in Chinese high-risk childhood ALL.en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/w2q01742820g519m/en
dc.subjectAcute lymphoblastic leukemiaen
dc.subjectHLAen
dc.subjecthuman leukocyte antigenen
dc.subjectHong Kong Chineseen
dc.subjectTransplant candidatesen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAsian Continental Ancestry Group-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDisease Susceptibility-
dc.subject.meshDisease-Free Survival-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHLA-A Antigens-
dc.subject.meshHLA-B Antigens-
dc.subject.meshHong Kong-
dc.subject.meshHumans-
dc.subject.meshLeukocytosis-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshPrognosis-
dc.subject.meshRecurrence-
dc.subject.meshRetrospective Studies-
dc.subject.meshSex Characteristics-
dc.subject.meshTumor Markers, Biological-
dc.titleHLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation leukocytosis: A retrospective analysis on 53 transplant candidates (1989-2003).en
dc.typeArticleen
dc.identifier.journalAnnals of Hematologyen

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