Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research.

2.50
Hdl Handle:
http://hdl.handle.net/10146/68255
Title:
Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research.
Authors:
Fenton, Jenifer I.; Hord, Norman G.
Abstract:
Clinical evidence reveals that the efficacy of dietary factors to prevent cancer is probably stage-dependent. The ability to demonstrate stage-specific effects of dietary compounds on normal, preneoplastic and malignant cell models may provide insights into puzzling clinical results from cancer chemoprevention trials. The relevance of these models to the field of cancer prevention is immense and will undoubtedly facilitate the ability to discover which dietary factors are most effective at preventing cancer and which, if any, specific steps in neoplastic transformation render cells refractory to the effects of dietary compounds. There are illustrative examples where exposure of high-risk individuals to dietary chemopreventive agents increases rather than decreases cancer risk. While geneticists and clinical oncologists acknowledge the morphological continuum along which tumors develop in specific tissues, tumor cells, rather than normal and preneoplastic cells, continue to be the primary in vitro reductionist tool employed to elucidate mechanisms underlying disease progression and to investigate the potential utility of dietary as well as other chemopreventive agents. Currently, there are few relevant model systems to study the progression of neoplastic transformation, especially in epithelial cells. We highlight examples of model systems isolated from prostate, breast, endometrial and intestinal tissue, with special emphasis on a specific set of non-tumorigenic, conditionally immortal cell lines derived from C57/BL6 mice [YAMC (Young Adult Mouse Colon cells; Apc+/+) cells and IMCE (Immorto-Min Colonic Epithelium cells; ApcMin/+) cells] that have yielded important information on early events in colorectal neoplasia development. These cell lines are an illustrative example of how researchers can examine stage-dependent effects of specific dietary components on carcinogenesis. The utilization of cell culture systems modeling early, middle and late stages of tumorigenesis will yield important insights into mechanisms by which dietary components impact cancer progression.
Citation:
Carcinogenesis 2006, 27 (5):893-902
Journal:
Carcinogenesis
Issue Date:
May-2006
URI:
http://hdl.handle.net/10146/68255
DOI:
10.1093/carcin/bgi355
PubMed ID:
16474168
Additional Links:
http://carcin.oxfordjournals.org/cgi/content/full/27/5/893
Type:
Article
Language:
en
Description:
KEYWORDS - CLASSIFICATION: Adult;Animals;Anticarcinogenic Agents;Cell Line;Cell Line,Tumor;Colon;diet therapy;Diet;Disease Models,Animal;Disease Progression;Epithelium;Genome;Humans;mechanisms of carcinogenesis;Mice;Mice,Inbred C57BL;Neoplasms;prevention & control;Research;Risk;therapeutic use;utilization.
ISSN:
0143-3334
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorFenton, Jenifer I.-
dc.contributor.authorHord, Norman G.-
dc.date.accessioned2009-05-15T08:19:36Z-
dc.date.available2009-05-15T08:19:36Z-
dc.date.issued2006-05-
dc.identifier.citationCarcinogenesis 2006, 27 (5):893-902en
dc.identifier.issn0143-3334-
dc.identifier.pmid16474168-
dc.identifier.doi10.1093/carcin/bgi355-
dc.identifier.urihttp://hdl.handle.net/10146/68255-
dc.descriptionKEYWORDS - CLASSIFICATION: Adult;Animals;Anticarcinogenic Agents;Cell Line;Cell Line,Tumor;Colon;diet therapy;Diet;Disease Models,Animal;Disease Progression;Epithelium;Genome;Humans;mechanisms of carcinogenesis;Mice;Mice,Inbred C57BL;Neoplasms;prevention & control;Research;Risk;therapeutic use;utilization.en
dc.description.abstractClinical evidence reveals that the efficacy of dietary factors to prevent cancer is probably stage-dependent. The ability to demonstrate stage-specific effects of dietary compounds on normal, preneoplastic and malignant cell models may provide insights into puzzling clinical results from cancer chemoprevention trials. The relevance of these models to the field of cancer prevention is immense and will undoubtedly facilitate the ability to discover which dietary factors are most effective at preventing cancer and which, if any, specific steps in neoplastic transformation render cells refractory to the effects of dietary compounds. There are illustrative examples where exposure of high-risk individuals to dietary chemopreventive agents increases rather than decreases cancer risk. While geneticists and clinical oncologists acknowledge the morphological continuum along which tumors develop in specific tissues, tumor cells, rather than normal and preneoplastic cells, continue to be the primary in vitro reductionist tool employed to elucidate mechanisms underlying disease progression and to investigate the potential utility of dietary as well as other chemopreventive agents. Currently, there are few relevant model systems to study the progression of neoplastic transformation, especially in epithelial cells. We highlight examples of model systems isolated from prostate, breast, endometrial and intestinal tissue, with special emphasis on a specific set of non-tumorigenic, conditionally immortal cell lines derived from C57/BL6 mice [YAMC (Young Adult Mouse Colon cells; Apc+/+) cells and IMCE (Immorto-Min Colonic Epithelium cells; ApcMin/+) cells] that have yielded important information on early events in colorectal neoplasia development. These cell lines are an illustrative example of how researchers can examine stage-dependent effects of specific dietary components on carcinogenesis. The utilization of cell culture systems modeling early, middle and late stages of tumorigenesis will yield important insights into mechanisms by which dietary components impact cancer progression.en
dc.language.isoenen
dc.relation.urlhttp://carcin.oxfordjournals.org/cgi/content/full/27/5/893en
dc.subject.meshAnimals-
dc.subject.meshAnticarcinogenic Agents-
dc.subject.meshCell Line-
dc.subject.meshCell Line, Tumor-
dc.subject.meshDiet-
dc.subject.meshDisease Models, Animal-
dc.subject.meshDisease Progression-
dc.subject.meshGenome-
dc.subject.meshHumans-
dc.subject.meshMice-
dc.subject.meshMice, Inbred C57BL-
dc.subject.meshNeoplasms-
dc.subject.meshRisk-
dc.titleStage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research.en
dc.typeArticleen
dc.identifier.journalCarcinogenesisen

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