Allyl sulfur compounds from garlic modulate aberrant crypt formation.

2.50
Hdl Handle:
http://hdl.handle.net/10146/67741
Title:
Allyl sulfur compounds from garlic modulate aberrant crypt formation.
Authors:
Ross, Sharon A.; Finley, John W.; Milner, John A.
Abstract:
The health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided.
Citation:
J. Nutr. 2006, 136 (3 Suppl):852S-854S
Journal:
The Journal of nutrition
Issue Date:
Mar-2006
URI:
http://hdl.handle.net/10146/67741
PubMed ID:
16484579
Additional Links:
http://jn.nutrition.org/cgi/content/full/136/3/852S
Type:
Article
Language:
en
Description:
KEYWORDS - CLASSIFICATION: Adenoma;Animals;Anticarcinogenic Agents;chemically induced;Colonic Neoplasms;dietary modulation of cancer & cancer biomarkers;dietary modulation of carcinogenesis-related pathways;Disease Models,Animal;Garlic;prevention & control;Plant Extracts;Precancerous Conditions;Research;Rodentia;Sulfinic Acids;therapeutic use.
ISSN:
0022-3166
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorRoss, Sharon A.-
dc.contributor.authorFinley, John W.-
dc.contributor.authorMilner, John A.-
dc.date.accessioned2009-05-11T09:01:28Z-
dc.date.available2009-05-11T09:01:28Z-
dc.date.issued2006-03-
dc.identifier.citationJ. Nutr. 2006, 136 (3 Suppl):852S-854Sen
dc.identifier.issn0022-3166-
dc.identifier.pmid16484579-
dc.identifier.urihttp://hdl.handle.net/10146/67741-
dc.descriptionKEYWORDS - CLASSIFICATION: Adenoma;Animals;Anticarcinogenic Agents;chemically induced;Colonic Neoplasms;dietary modulation of cancer & cancer biomarkers;dietary modulation of carcinogenesis-related pathways;Disease Models,Animal;Garlic;prevention & control;Plant Extracts;Precancerous Conditions;Research;Rodentia;Sulfinic Acids;therapeutic use.en
dc.description.abstractThe health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided.en
dc.language.isoenen
dc.relation.urlhttp://jn.nutrition.org/cgi/content/full/136/3/852Sen
dc.subjectAberrant crypt focien
dc.subjectColorectal canceren
dc.subjectGarlicen
dc.subjectAllyl sulfur compoundsen
dc.subject.meshAdenoma-
dc.subject.meshAnimals-
dc.subject.meshAnticarcinogenic Agents-
dc.subject.meshColonic Neoplasms-
dc.subject.meshDisease Models, Animal-
dc.subject.meshGarlic-
dc.subject.meshPlant Extracts-
dc.subject.meshPrecancerous Conditions-
dc.subject.meshRodentia-
dc.subject.meshSulfinic Acids-
dc.titleAllyl sulfur compounds from garlic modulate aberrant crypt formation.en
dc.typeArticleen
dc.identifier.journalThe Journal of nutritionen

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