An in vivo biocompatibility study of surgical meshes made from bacterial cellulose modified with chitosan.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618212
Title:
An in vivo biocompatibility study of surgical meshes made from bacterial cellulose modified with chitosan.
Authors:
Piasecka-Zelga, Joanna; Zelga, Piotr; Szulc, Joanna; Wietecha, Justyna; Ciechańska, Danuta
Abstract:
Bacterial cellulose modified with chitosan (MBC) is an innovative biomaterial used in regenerative medicine which may potentially improve treatment outcomes mesh for hernia repair surgery by facilitating better absorption in native tissue with less risk of mesh-related infections. The aim of the present study was to evaluate the biocompatibility of mesh based on MBC, and determine whether immunological reactions occur due to hypersensitivity to the implants. Forty five Imp:WIST rats were randomly assigned to be implanted with one of three mesh types: simple polypropylene mesh (n = 15), mesh modified by bacterial cellulose only (n = 15) and MBC mesh (n = 15) and evaluated after one and three months following intramuscular implantation. For MBC mesh, basic toxicological studies, i.e. Acute Dermal Irritation, Intradermal Reactivity and Acute Sensitization (GPMT), were also carried out on 9 Imp:BN albino rabbits and 15 Imp:D-H guinea pigs. The lowest immune response and the highest degree of fibroplasia were observed for MBC mesh both after one and three months after implantation. Toxicological studies classified the tested MBC mesh as a barely perceptible irritant with no signs of sensitization or allergic reactions observed during the studies. The findings indicate that MBC mesh does not irritate, does not sensitize and does not cause hypersensitivity in the implant site, and therefore presents a low risk of provoking such reactions in humans.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Citation:
Int. J. Biol. Macromol.2018, 116:1119-1127
Journal:
International Journal of Biological Macromolecules
Issue Date:
18-May-2018
URI:
http://hdl.handle.net/10146/618212
DOI:
10.1016/j.ijbiomac.2018.05.123
PubMed ID:
29782983
Additional Links:
https://www.sciencedirect.com/science/article/pii/S014181301830103X?via%3Dihub
Type:
Article
Language:
en
ISSN:
1879-0003
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPiasecka-Zelga, Joannaen
dc.contributor.authorZelga, Piotren
dc.contributor.authorSzulc, Joannaen
dc.contributor.authorWietecha, Justynaen
dc.contributor.authorCiechańska, Danutaen
dc.date.accessioned2018-06-04T10:39:53Z-
dc.date.available2018-06-04T10:39:53Z-
dc.date.issued2018-05-18-
dc.identifier.citationInt. J. Biol. Macromol.2018, 116:1119-1127en
dc.identifier.issn1879-0003-
dc.identifier.pmid29782983-
dc.identifier.doi10.1016/j.ijbiomac.2018.05.123-
dc.identifier.urihttp://hdl.handle.net/10146/618212-
dc.description.abstractBacterial cellulose modified with chitosan (MBC) is an innovative biomaterial used in regenerative medicine which may potentially improve treatment outcomes mesh for hernia repair surgery by facilitating better absorption in native tissue with less risk of mesh-related infections. The aim of the present study was to evaluate the biocompatibility of mesh based on MBC, and determine whether immunological reactions occur due to hypersensitivity to the implants. Forty five Imp:WIST rats were randomly assigned to be implanted with one of three mesh types: simple polypropylene mesh (n = 15), mesh modified by bacterial cellulose only (n = 15) and MBC mesh (n = 15) and evaluated after one and three months following intramuscular implantation. For MBC mesh, basic toxicological studies, i.e. Acute Dermal Irritation, Intradermal Reactivity and Acute Sensitization (GPMT), were also carried out on 9 Imp:BN albino rabbits and 15 Imp:D-H guinea pigs. The lowest immune response and the highest degree of fibroplasia were observed for MBC mesh both after one and three months after implantation. Toxicological studies classified the tested MBC mesh as a barely perceptible irritant with no signs of sensitization or allergic reactions observed during the studies. The findings indicate that MBC mesh does not irritate, does not sensitize and does not cause hypersensitivity in the implant site, and therefore presents a low risk of provoking such reactions in humans.en
dc.language.isoenen
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S014181301830103X?via%3Dihuben
dc.rightsArchived with thanks to International journal of biological macromoleculesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectbacterial celluloseen
dc.subjectbiocompatibilityen
dc.subjectcontact allergyen
dc.subjecthernia repairen
dc.subjecthistopathologyen
dc.subjectIn vivoen
dc.titleAn in vivo biocompatibility study of surgical meshes made from bacterial cellulose modified with chitosan.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalInternational Journal of Biological Macromoleculesen

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