Environmental Tobacco Smoke Exposure during Pregnancy and Child Neurodevelopment.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618167
Title:
Environmental Tobacco Smoke Exposure during Pregnancy and Child Neurodevelopment.
Authors:
Polanska, Kinga ( 0000-0002-3212-2307 ) ; Krol, Anna; Merecz-Kot, Dorota ( 0000-0002-8294-4309 ) ; Ligocka, Danuta ( 0000-0001-6075-0792 ) ; Mikolajewska, Karolina; Mirabella, Fiorino; Chiarotti, Flavia; Calamandrei, Gemma; Hanke, Wojciech ( 0000-0001-7162-2569 )
Abstract:
The developing fetus is especially vulnerable to environmental toxicants, including tobacco constituents. The aim of this study was to assess the impact of environmental tobacco smoke (ETS) exposure during pregnancy on child neurodevelopment within the first two years of life. The study population consisted of 461 non-smoking pregnant women (saliva cotinine level <10 ng/mL). Maternal passive smoking was assessed based on the cotinine level in saliva analyzed by the use of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS) and by questionnaire data. The cotinine cut-off value for passive smoking was established at 1.5 ng/mL (sensitivity 63%, specificity 71%). Psychomotor development was assessed in children at the age of one- and two-years using the Bayley Scales of Infant and Toddler Development. Approximately 30% of the women were exposed to ETS during pregnancy. The multivariate linear regression model indicated that ETS exposure in the 1st and the 2nd trimesters of pregnancy were associated with decreasing child language functions at the age of one (β = -3.0, p = 0.03, and β = -4.1, p = 0.008, respectively), and two years (β = -3.8, p = 0.05, and β = -6.3, p = 0.005, respectively). A negative association was found for cotinine level ≥1.5 ng/mL in the 2nd trimester of pregnancy and child cognition at the age of 2 (β = -4.6, p = 0.05), as well as cotinine levels ≥1.5 ng/mL in all trimesters of pregnancy and child motor abilities at two years of age (β = -3.9, p = 0.06, β = -5.3, p = 0.02, and β = -4.2, p = 0.05, for the 1st, the 2nd, and the 3rd trimester of pregnancy, respectively; for the 1st trimester the effect was of borderline statistical significance). This study confirmed that ETS exposure during pregnancy can have a negative impact on child psychomotor development within the first two years of life and underscore the importance of public health interventions aiming at reducing this exposure.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland
Citation:
2017, 14 (7) Int J Environ Res Public Health
Journal:
International Journal of Environmental Research and Public Health
Issue Date:
17-Jul-2017
URI:
http://hdl.handle.net/10146/618167
DOI:
10.3390/ijerph14070796
PubMed ID:
28714930
Additional Links:
http://www.mdpi.com/1660-4601/14/7/796
Type:
Article
Language:
en
ISSN:
1660-4601
Sponsors:
This work has been funded by the National Science Centre, Poland, under grant no. DEC-2014/15/B/NZ7/00998 and partly by the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 603946 and the Ministry of Science and Higher Education under grant agreement no. 3068/7.PR/2014/2.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPolanska, Kingaen
dc.contributor.authorKrol, Annaen
dc.contributor.authorMerecz-Kot, Dorotaen
dc.contributor.authorLigocka, Danutaen
dc.contributor.authorMikolajewska, Karolinaen
dc.contributor.authorMirabella, Fiorinoen
dc.contributor.authorChiarotti, Flaviaen
dc.contributor.authorCalamandrei, Gemmaen
dc.contributor.authorHanke, Wojciechen
dc.date.accessioned2017-10-20T09:08:42Z-
dc.date.available2017-10-20T09:08:42Z-
dc.date.issued2017-07-17-
dc.identifier.citation2017, 14 (7) Int J Environ Res Public Healthen
dc.identifier.issn1660-4601-
dc.identifier.pmid28714930-
dc.identifier.doi10.3390/ijerph14070796-
dc.identifier.urihttp://hdl.handle.net/10146/618167-
dc.description.abstractThe developing fetus is especially vulnerable to environmental toxicants, including tobacco constituents. The aim of this study was to assess the impact of environmental tobacco smoke (ETS) exposure during pregnancy on child neurodevelopment within the first two years of life. The study population consisted of 461 non-smoking pregnant women (saliva cotinine level <10 ng/mL). Maternal passive smoking was assessed based on the cotinine level in saliva analyzed by the use of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS) and by questionnaire data. The cotinine cut-off value for passive smoking was established at 1.5 ng/mL (sensitivity 63%, specificity 71%). Psychomotor development was assessed in children at the age of one- and two-years using the Bayley Scales of Infant and Toddler Development. Approximately 30% of the women were exposed to ETS during pregnancy. The multivariate linear regression model indicated that ETS exposure in the 1st and the 2nd trimesters of pregnancy were associated with decreasing child language functions at the age of one (β = -3.0, p = 0.03, and β = -4.1, p = 0.008, respectively), and two years (β = -3.8, p = 0.05, and β = -6.3, p = 0.005, respectively). A negative association was found for cotinine level ≥1.5 ng/mL in the 2nd trimester of pregnancy and child cognition at the age of 2 (β = -4.6, p = 0.05), as well as cotinine levels ≥1.5 ng/mL in all trimesters of pregnancy and child motor abilities at two years of age (β = -3.9, p = 0.06, β = -5.3, p = 0.02, and β = -4.2, p = 0.05, for the 1st, the 2nd, and the 3rd trimester of pregnancy, respectively; for the 1st trimester the effect was of borderline statistical significance). This study confirmed that ETS exposure during pregnancy can have a negative impact on child psychomotor development within the first two years of life and underscore the importance of public health interventions aiming at reducing this exposure.en
dc.description.sponsorshipThis work has been funded by the National Science Centre, Poland, under grant no. DEC-2014/15/B/NZ7/00998 and partly by the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 603946 and the Ministry of Science and Higher Education under grant agreement no. 3068/7.PR/2014/2.en
dc.language.isoenen
dc.relation.urlhttp://www.mdpi.com/1660-4601/14/7/796en
dc.rightsArchived with thanks to International journal of environmental research and public healthen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectenvironmental tobacco smokeen
dc.subjectpassive smokingen
dc.subjectpregnancyen
dc.subjectprenatal perioden
dc.subjectchild neurodevelopmenten
dc.subjectcognitiveen
dc.subjectlanguage and motor functionsen
dc.titleEnvironmental Tobacco Smoke Exposure during Pregnancy and Child Neurodevelopment.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Polanden
dc.identifier.journalInternational Journal of Environmental Research and Public Healthen

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