Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618165
Title:
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
Authors:
Lesseur, Corina; Diergaarde, Brenda; Olshan, Andrew F; Wünsch-Filho, Victor; Ness, Andrew R; Liu, Geoffrey; Lacko, Martin; Eluf-Neto, José; Franceschi, Silvia; Lagiou, Pagona; Macfarlane, Gary J; Richiardi, Lorenzo; Boccia, Stefania; Polesel, Jerry; Kjaerheim, Kristina; Zaridze, David; Johansson, Mattias; Menezes, Ana M; Curado, Maria Paula; Robinson, Max; Ahrens, Wolfgang; Canova, Cristina; Znaor, Ariana; Castellsagué, Xavier; Conway, David I; Holcátová, Ivana; Mates, Dana; Vilensky, Marta; Healy, Claire M; Szeszenia-Dąbrowska, Neonila; Fabiánová, Eleonóra; Lissowska, Jolanta; Grandis, Jennifer R; Weissler, Mark C; Tajara, Eloiza H; Nunes, Fabio D; de Carvalho, Marcos B; Thomas, Steve; Hung, Rayjean J; Peters, Wilbert H M; Herrero, Rolando; Cadoni, Gabriella; Bueno-de-Mesquita, H Bas; Steffen, Annika; Agudo, Antonio; Shangina, Oxana; Xiao, Xiangjun; Gaborieau, Valérie; Chabrier, Amélie; Anantharaman, Devasena; Boffetta, Paolo; Amos, Christopher I; McKay, James D; Brennan, Paul
Abstract:
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland
Citation:
Nat. Genet. 2016, 48 (12):1544-1550
Journal:
Nature Genetics
Issue Date:
Dec-2016
URI:
http://hdl.handle.net/10146/618165
DOI:
10.1038/ng.3685
PubMed ID:
27749845
Type:
Dataset
Language:
en
ISSN:
1546-1718
Appears in Collections:
Research data

Full metadata record

DC FieldValue Language
dc.contributor.authorLesseur, Corinaen
dc.contributor.authorDiergaarde, Brendaen
dc.contributor.authorOlshan, Andrew Fen
dc.contributor.authorWünsch-Filho, Victoren
dc.contributor.authorNess, Andrew Ren
dc.contributor.authorLiu, Geoffreyen
dc.contributor.authorLacko, Martinen
dc.contributor.authorEluf-Neto, Joséen
dc.contributor.authorFranceschi, Silviaen
dc.contributor.authorLagiou, Pagonaen
dc.contributor.authorMacfarlane, Gary Jen
dc.contributor.authorRichiardi, Lorenzoen
dc.contributor.authorBoccia, Stefaniaen
dc.contributor.authorPolesel, Jerryen
dc.contributor.authorKjaerheim, Kristinaen
dc.contributor.authorZaridze, Daviden
dc.contributor.authorJohansson, Mattiasen
dc.contributor.authorMenezes, Ana Men
dc.contributor.authorCurado, Maria Paulaen
dc.contributor.authorRobinson, Maxen
dc.contributor.authorAhrens, Wolfgangen
dc.contributor.authorCanova, Cristinaen
dc.contributor.authorZnaor, Arianaen
dc.contributor.authorCastellsagué, Xavieren
dc.contributor.authorConway, David Ien
dc.contributor.authorHolcátová, Ivanaen
dc.contributor.authorMates, Danaen
dc.contributor.authorVilensky, Martaen
dc.contributor.authorHealy, Claire Men
dc.contributor.authorSzeszenia-Dąbrowska, Neonilaen
dc.contributor.authorFabiánová, Eleonóraen
dc.contributor.authorLissowska, Jolantaen
dc.contributor.authorGrandis, Jennifer Ren
dc.contributor.authorWeissler, Mark Cen
dc.contributor.authorTajara, Eloiza Hen
dc.contributor.authorNunes, Fabio Den
dc.contributor.authorde Carvalho, Marcos Ben
dc.contributor.authorThomas, Steveen
dc.contributor.authorHung, Rayjean Jen
dc.contributor.authorPeters, Wilbert H Men
dc.contributor.authorHerrero, Rolandoen
dc.contributor.authorCadoni, Gabriellaen
dc.contributor.authorBueno-de-Mesquita, H Basen
dc.contributor.authorSteffen, Annikaen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorShangina, Oxanaen
dc.contributor.authorXiao, Xiangjunen
dc.contributor.authorGaborieau, Valérieen
dc.contributor.authorChabrier, Amélieen
dc.contributor.authorAnantharaman, Devasenaen
dc.contributor.authorBoffetta, Paoloen
dc.contributor.authorAmos, Christopher Ien
dc.contributor.authorMcKay, James Den
dc.contributor.authorBrennan, Paulen
dc.date.accessioned2017-10-20T08:18:27Z-
dc.date.available2017-10-20T08:18:27Z-
dc.date.issued2016-12-
dc.identifier.citationNat. Genet. 2016, 48 (12):1544-1550en
dc.identifier.issn1546-1718-
dc.identifier.pmid27749845-
dc.identifier.doi10.1038/ng.3685-
dc.identifier.urihttp://hdl.handle.net/10146/618165-
dc.description.abstractWe conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.en
dc.language.isoenen
dc.rightsArchived with thanks to Nature geneticsen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.meshAged-
dc.subject.meshCase-Control Studies-
dc.subject.meshFemale-
dc.subject.meshGenetic Markers-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenetic Variation-
dc.subject.meshGenome-Wide Association Study-
dc.subject.meshHLA Antigens-
dc.subject.meshHaplotypes-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMouth-
dc.subject.meshMouth Neoplasms-
dc.subject.meshPapillomaviridae-
dc.subject.meshPapillomavirus Infections-
dc.subject.meshPharyngeal Neoplasms-
dc.titleGenome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.en
dc.typeDataseten
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Polanden
dc.identifier.journalNature Geneticsen
dc.relation.isPartOfhttp://ecnis.openrepository.com/ecnis/handle/10146/618164-

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