Genome-wide association study identifies multiple risk loci for renal cell carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618150
Title:
Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Authors:
Scelo, Ghislaine; Purdue, Mark P; Brown, Kevin M; Johansson, Mattias; Wang, Zhaoming; Eckel-Passow, Jeanette E; Ye, Yuanqing; Hofmann, Jonathan N; Choi, Jiyeon; Foll, Matthieu; Gaborieau, Valerie; Machiela, Mitchell J; Colli, Leandro M; Li, Peng; Sampson, Joshua N; Abedi-Ardekani, Behnoush; Besse, Celine; Blanche, Helene; Boland, Anne; Burdette, Laurie; Chabrier, Amelie; Durand, Geoffroy; Le Calvez-Kelm, Florence; Prokhortchouk, Egor; Robinot, Nivonirina; Skryabin, Konstantin G; Wozniak, Magdalena B; Yeager, Meredith; Basta-Jovanovic, Gordana; Dzamic, Zoran; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Mukeriya, Anush; Rascu, Stefan; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleonora; Jinga, Viorel; Lissowska, Jolanta; Lubinski, Jan; Navratilova, Marie; Rudnai, Peter; Szeszenia-Dabrowska, Neonila ( 0000-0001-5307-7720 ) ; Benhamou, Simone; Cancel-Tassin, Geraldine; Cussenot, Olivier; Baglietto, Laura; Boeing, Heiner; Khaw, Kay-Tee; Weiderpass, Elisabete; Ljungberg, Borje; Sitaram, Raviprakash T; Bruinsma, Fiona; Jordan, Susan J; Severi, Gianluca; Winship, Ingrid; Hveem, Kristian; Vatten, Lars J; Fletcher, Tony; Koppova, Kvetoslava; Larsson, Susanna C; Wolk, Alicja; Banks, Rosamonde E; Selby, Peter J; Easton, Douglas F; Pharoah, Paul; Andreotti, Gabriella; Freeman, Laura E Beane; Koutros, Stella; Albanes, Demetrius; Männistö, Satu; Weinstein, Stephanie; Clark, Peter E; Edwards, Todd L; Lipworth, Loren; Gapstur, Susan M; Stevens, Victoria L; Carol, Hallie; Freedman, Matthew L; Pomerantz, Mark M; Cho, Eunyoung; Kraft, Peter; Preston, Mark A; Wilson, Kathryn M; Michael Gaziano, J; Sesso, Howard D; Black, Amanda; Freedman, Neal D; Huang, Wen-Yi; Anema, John G; Kahnoski, Richard J; Lane, Brian R; Noyes, Sabrina L; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet L; Johnson, Lisa; Luo, Juhua; Buring, Julie; Lee, I-Min; Chow, Wong-Ho; Moore, Lee E; Wood, Christopher; Eisen, Timothy; Henrion, Marc; Larkin, James; Barman, Poulami; Leibovich, Bradley C; Choueiri, Toni K; Mark Lathrop, G; Rothman, Nathaniel; Deleuze, Jean-Francois; McKay, James D; Parker, Alexander S; Wu, Xifeng; Houlston, Richard S; Brennan, Paul; Chanock, Stephen J
Abstract:
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10(-10)), 3p22.1 (rs67311347, P=2.5 × 10(-8)), 3q26.2 (rs10936602, P=8.8 × 10(-9)), 8p21.3 (rs2241261, P=5.8 × 10(-9)), 10q24.33-q25.1 (rs11813268, P=3.9 × 10(-8)), 11q22.3 (rs74911261, P=2.1 × 10(-10)) and 14q24.2 (rs4903064, P=2.2 × 10(-24)). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland
Citation:
Nat Commun 2017, 8:15724
Journal:
Nature Communications
Issue Date:
9-Jun-2017
URI:
http://hdl.handle.net/10146/618150
DOI:
10.1038/ncomms15724
PubMed ID:
28598434
Additional Links:
https://www.nature.com/articles/ncomms15724
Type:
Article
Language:
en
ISSN:
2041-1723
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorScelo, Ghislaineen
dc.contributor.authorPurdue, Mark Pen
dc.contributor.authorBrown, Kevin Men
dc.contributor.authorJohansson, Mattiasen
dc.contributor.authorWang, Zhaomingen
dc.contributor.authorEckel-Passow, Jeanette Een
dc.contributor.authorYe, Yuanqingen
dc.contributor.authorHofmann, Jonathan Nen
dc.contributor.authorChoi, Jiyeonen
dc.contributor.authorFoll, Matthieuen
dc.contributor.authorGaborieau, Valerieen
dc.contributor.authorMachiela, Mitchell Jen
dc.contributor.authorColli, Leandro Men
dc.contributor.authorLi, Pengen
dc.contributor.authorSampson, Joshua Nen
dc.contributor.authorAbedi-Ardekani, Behnoushen
dc.contributor.authorBesse, Celineen
dc.contributor.authorBlanche, Heleneen
dc.contributor.authorBoland, Anneen
dc.contributor.authorBurdette, Laurieen
dc.contributor.authorChabrier, Amelieen
dc.contributor.authorDurand, Geoffroyen
dc.contributor.authorLe Calvez-Kelm, Florenceen
dc.contributor.authorProkhortchouk, Egoren
dc.contributor.authorRobinot, Nivonirinaen
dc.contributor.authorSkryabin, Konstantin Gen
dc.contributor.authorWozniak, Magdalena Ben
dc.contributor.authorYeager, Meredithen
dc.contributor.authorBasta-Jovanovic, Gordanaen
dc.contributor.authorDzamic, Zoranen
dc.contributor.authorForetova, Lenkaen
dc.contributor.authorHolcatova, Ivanaen
dc.contributor.authorJanout, Vladimiren
dc.contributor.authorMates, Danaen
dc.contributor.authorMukeriya, Anushen
dc.contributor.authorRascu, Stefanen
dc.contributor.authorZaridze, Daviden
dc.contributor.authorBencko, Vladimiren
dc.contributor.authorCybulski, Cezaryen
dc.contributor.authorFabianova, Eleonoraen
dc.contributor.authorJinga, Viorelen
dc.contributor.authorLissowska, Jolantaen
dc.contributor.authorLubinski, Janen
dc.contributor.authorNavratilova, Marieen
dc.contributor.authorRudnai, Peteren
dc.contributor.authorSzeszenia-Dabrowska, Neonilaen
dc.contributor.authorBenhamou, Simoneen
dc.contributor.authorCancel-Tassin, Geraldineen
dc.contributor.authorCussenot, Olivieren
dc.contributor.authorBaglietto, Lauraen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorWeiderpass, Elisabeteen
dc.contributor.authorLjungberg, Borjeen
dc.contributor.authorSitaram, Raviprakash Ten
dc.contributor.authorBruinsma, Fionaen
dc.contributor.authorJordan, Susan Jen
dc.contributor.authorSeveri, Gianlucaen
dc.contributor.authorWinship, Ingriden
dc.contributor.authorHveem, Kristianen
dc.contributor.authorVatten, Lars Jen
dc.contributor.authorFletcher, Tonyen
dc.contributor.authorKoppova, Kvetoslavaen
dc.contributor.authorLarsson, Susanna Cen
dc.contributor.authorWolk, Alicjaen
dc.contributor.authorBanks, Rosamonde Een
dc.contributor.authorSelby, Peter Jen
dc.contributor.authorEaston, Douglas Fen
dc.contributor.authorPharoah, Paulen
dc.contributor.authorAndreotti, Gabriellaen
dc.contributor.authorFreeman, Laura E Beaneen
dc.contributor.authorKoutros, Stellaen
dc.contributor.authorAlbanes, Demetriusen
dc.contributor.authorMännistö, Satuen
dc.contributor.authorWeinstein, Stephanieen
dc.contributor.authorClark, Peter Een
dc.contributor.authorEdwards, Todd Len
dc.contributor.authorLipworth, Lorenen
dc.contributor.authorGapstur, Susan Men
dc.contributor.authorStevens, Victoria Len
dc.contributor.authorCarol, Hallieen
dc.contributor.authorFreedman, Matthew Len
dc.contributor.authorPomerantz, Mark Men
dc.contributor.authorCho, Eunyoungen
dc.contributor.authorKraft, Peteren
dc.contributor.authorPreston, Mark Aen
dc.contributor.authorWilson, Kathryn Men
dc.contributor.authorMichael Gaziano, Jen
dc.contributor.authorSesso, Howard Den
dc.contributor.authorBlack, Amandaen
dc.contributor.authorFreedman, Neal Den
dc.contributor.authorHuang, Wen-Yien
dc.contributor.authorAnema, John Gen
dc.contributor.authorKahnoski, Richard Jen
dc.contributor.authorLane, Brian Ren
dc.contributor.authorNoyes, Sabrina Len
dc.contributor.authorPetillo, Daviden
dc.contributor.authorTeh, Bin Teanen
dc.contributor.authorPeters, Ulrikeen
dc.contributor.authorWhite, Emilyen
dc.contributor.authorAnderson, Garnet Len
dc.contributor.authorJohnson, Lisaen
dc.contributor.authorLuo, Juhuaen
dc.contributor.authorBuring, Julieen
dc.contributor.authorLee, I-Minen
dc.contributor.authorChow, Wong-Hoen
dc.contributor.authorMoore, Lee Een
dc.contributor.authorWood, Christopheren
dc.contributor.authorEisen, Timothyen
dc.contributor.authorHenrion, Marcen
dc.contributor.authorLarkin, Jamesen
dc.contributor.authorBarman, Poulamien
dc.contributor.authorLeibovich, Bradley Cen
dc.contributor.authorChoueiri, Toni Ken
dc.contributor.authorMark Lathrop, Gen
dc.contributor.authorRothman, Nathanielen
dc.contributor.authorDeleuze, Jean-Francoisen
dc.contributor.authorMcKay, James Den
dc.contributor.authorParker, Alexander Sen
dc.contributor.authorWu, Xifengen
dc.contributor.authorHoulston, Richard Sen
dc.contributor.authorBrennan, Paulen
dc.contributor.authorChanock, Stephen Jen
dc.date.accessioned2017-08-25T12:12:37Z-
dc.date.available2017-08-25T12:12:37Z-
dc.date.issued2017-06-09-
dc.identifier.citationNat Commun 2017, 8:15724en
dc.identifier.issn2041-1723-
dc.identifier.pmid28598434-
dc.identifier.doi10.1038/ncomms15724-
dc.identifier.urihttp://hdl.handle.net/10146/618150-
dc.description.abstractPrevious genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10(-10)), 3p22.1 (rs67311347, P=2.5 × 10(-8)), 3q26.2 (rs10936602, P=8.8 × 10(-9)), 8p21.3 (rs2241261, P=5.8 × 10(-9)), 10q24.33-q25.1 (rs11813268, P=3.9 × 10(-8)), 11q22.3 (rs74911261, P=2.1 × 10(-10)) and 14q24.2 (rs4903064, P=2.2 × 10(-24)). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.en
dc.language.isoenen
dc.relation.urlhttps://www.nature.com/articles/ncomms15724en
dc.rightsArchived with thanks to Nature communicationsen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectcancer epidemiologyen
dc.subjectGenome-Wide Association Studyen
dc.titleGenome-wide association study identifies multiple risk loci for renal cell carcinoma.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Polanden
dc.identifier.journalNature Communicationsen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.