Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618149
Title:
Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies.
Authors:
Olsson, Ann C; Vermeulen, Roel; Schüz, Joachim; Kromhout, Hans; Pesch, Beate; Peters, Susan; Behrens, Thomas; Portengen, Lützen; Mirabelli, Dario; Gustavsson, Per; Kendzia, Benjamin; Almansa, Josue; Luzon, Veronique; Vlaanderen, Jelle; Stücker, Isabelle; Guida, Florence; Consonni, Dario; Caporaso, Neil; Landi, Maria Teresa; Field, John; Brüske, Irene; Wichmann, Heinz-Erich; Siemiatycki, Jack; Parent, Marie-Elise; Richiardi, Lorenzo; Merletti, Franco; Jöckel, Karl-Heinz; Ahrens, Wolfgang; Pohlabeln, Hermann; Plato, Nils; Tardón, Adonina; Zaridze, David; McLaughlin, John; Demers, Paul; Szeszenia-Dabrowska, Neonila ( 0000-0001-5307-7720 ) ; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Stanescu Dumitru, Rodica; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Boffetta, Paolo; Bueno-de-Mesquita, Bas; Forastiere, Francesco; Brüning, Thomas; Straif, Kurt
Abstract:
Evidence is limited regarding risk and the shape of the exposure-response curve at low asbestos exposure levels. We estimated the exposure-response for occupational asbestos exposure and assessed the joint effect of asbestos exposure and smoking by sex and lung cancer subtype in general population studies.; We pooled 14 case-control studies conducted in 1985-2010 in Europe and Canada, including 17,705 lung cancer cases and 21,813 controls with detailed information on tobacco habits and lifetime occupations. We developed a quantitative job-exposure-matrix to estimate job-, time period-, and region-specific exposure levels. Fiber-years (ff/ml-years) were calculated for each subject by linking the matrix with individual occupational histories. We fit unconditional logistic regression models to estimate odds ratios (ORs), 95% confidence intervals (CIs), and trends.; The fully adjusted OR for ever-exposure to asbestos was 1.24 (95% CI, 1.18, 1.31) in men and 1.12 (95% CI, 0.95, 1.31) in women. In men, increasing lung cancer risk was observed with increasing exposure in all smoking categories and for all three major lung cancer subtypes. In women, lung cancer risk for all subtypes was increased in current smokers (ORs ~two-fold). The joint effect of asbestos exposure and smoking did not deviate from multiplicativity among men, and was more than additive among women.; Our results in men showed an excess risk of lung cancer and its subtypes at low cumulative exposure levels, with a steeper exposure-response slope in this exposure range than at higher, previously studied levels. (See video abstract at, http://links.lww.com/EDE/B161.).
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland
Citation:
Epidemiology 2017, 28 (2):288-299
Journal:
Epidemiology (Cambridge, Mass.)
Issue Date:
Mar-2017
URI:
http://hdl.handle.net/10146/618149
DOI:
10.1097/EDE.0000000000000604
PubMed ID:
28141674
Additional Links:
http://journals.lww.com/epidem/fulltext/2017/03000/Exposure_Response_Analyses_of_Asbestos_and_Lung.19.aspx
Type:
Article
Language:
en
ISSN:
1531-5487
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorOlsson, Ann Cen
dc.contributor.authorVermeulen, Roelen
dc.contributor.authorSchüz, Joachimen
dc.contributor.authorKromhout, Hansen
dc.contributor.authorPesch, Beateen
dc.contributor.authorPeters, Susanen
dc.contributor.authorBehrens, Thomasen
dc.contributor.authorPortengen, Lützenen
dc.contributor.authorMirabelli, Darioen
dc.contributor.authorGustavsson, Peren
dc.contributor.authorKendzia, Benjaminen
dc.contributor.authorAlmansa, Josueen
dc.contributor.authorLuzon, Veroniqueen
dc.contributor.authorVlaanderen, Jelleen
dc.contributor.authorStücker, Isabelleen
dc.contributor.authorGuida, Florenceen
dc.contributor.authorConsonni, Darioen
dc.contributor.authorCaporaso, Neilen
dc.contributor.authorLandi, Maria Teresaen
dc.contributor.authorField, Johnen
dc.contributor.authorBrüske, Ireneen
dc.contributor.authorWichmann, Heinz-Erichen
dc.contributor.authorSiemiatycki, Jacken
dc.contributor.authorParent, Marie-Eliseen
dc.contributor.authorRichiardi, Lorenzoen
dc.contributor.authorMerletti, Francoen
dc.contributor.authorJöckel, Karl-Heinzen
dc.contributor.authorAhrens, Wolfgangen
dc.contributor.authorPohlabeln, Hermannen
dc.contributor.authorPlato, Nilsen
dc.contributor.authorTardón, Adoninaen
dc.contributor.authorZaridze, Daviden
dc.contributor.authorMcLaughlin, Johnen
dc.contributor.authorDemers, Paulen
dc.contributor.authorSzeszenia-Dabrowska, Neonilaen
dc.contributor.authorLissowska, Jolantaen
dc.contributor.authorRudnai, Peteren
dc.contributor.authorFabianova, Eleonoraen
dc.contributor.authorStanescu Dumitru, Rodicaen
dc.contributor.authorBencko, Vladimiren
dc.contributor.authorForetova, Lenkaen
dc.contributor.authorJanout, Vladimiren
dc.contributor.authorBoffetta, Paoloen
dc.contributor.authorBueno-de-Mesquita, Basen
dc.contributor.authorForastiere, Francescoen
dc.contributor.authorBrüning, Thomasen
dc.contributor.authorStraif, Kurten
dc.date.accessioned2017-08-25T11:50:48Z-
dc.date.available2017-08-25T11:50:48Z-
dc.date.issued2017-03-
dc.identifier.citationEpidemiology 2017, 28 (2):288-299en
dc.identifier.issn1531-5487-
dc.identifier.pmid28141674-
dc.identifier.doi10.1097/EDE.0000000000000604-
dc.identifier.urihttp://hdl.handle.net/10146/618149-
dc.description.abstractEvidence is limited regarding risk and the shape of the exposure-response curve at low asbestos exposure levels. We estimated the exposure-response for occupational asbestos exposure and assessed the joint effect of asbestos exposure and smoking by sex and lung cancer subtype in general population studies.en
dc.description.abstractWe pooled 14 case-control studies conducted in 1985-2010 in Europe and Canada, including 17,705 lung cancer cases and 21,813 controls with detailed information on tobacco habits and lifetime occupations. We developed a quantitative job-exposure-matrix to estimate job-, time period-, and region-specific exposure levels. Fiber-years (ff/ml-years) were calculated for each subject by linking the matrix with individual occupational histories. We fit unconditional logistic regression models to estimate odds ratios (ORs), 95% confidence intervals (CIs), and trends.en
dc.description.abstractThe fully adjusted OR for ever-exposure to asbestos was 1.24 (95% CI, 1.18, 1.31) in men and 1.12 (95% CI, 0.95, 1.31) in women. In men, increasing lung cancer risk was observed with increasing exposure in all smoking categories and for all three major lung cancer subtypes. In women, lung cancer risk for all subtypes was increased in current smokers (ORs ~two-fold). The joint effect of asbestos exposure and smoking did not deviate from multiplicativity among men, and was more than additive among women.en
dc.description.abstractOur results in men showed an excess risk of lung cancer and its subtypes at low cumulative exposure levels, with a steeper exposure-response slope in this exposure range than at higher, previously studied levels. (See video abstract at, http://links.lww.com/EDE/B161.).en
dc.language.isoenen
dc.relation.urlhttp://journals.lww.com/epidem/fulltext/2017/03000/Exposure_Response_Analyses_of_Asbestos_and_Lung.19.aspxen
dc.rightsArchived with thanks to Epidemiology (Cambridge, Mass.)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectlung canceren
dc.subjectasbestos exposureen
dc.titleExposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Polanden
dc.identifier.journalEpidemiology (Cambridge, Mass.)en

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