Trafnosc diagnostyczna oznaczen alergenowo swoistych przeciwcial IgE w zawodowej alergii drog oddechowych na czynniki o duzej masie czasteczkowej.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618125
Title:
Trafnosc diagnostyczna oznaczen alergenowo swoistych przeciwcial IgE w zawodowej alergii drog oddechowych na czynniki o duzej masie czasteczkowej.
Authors:
Zgorzelska-Kowalik, Joanna; Walusiak-Skorupa, Jolanta ( 0000-0003-0836-6800 ) ; Nowakowska-Swirta, Ewa; Wiszniewska, Marta
Other Titles:
Diagnostic accuracy of specific IgE antibodies measurements in occupational airway allergy to high molecular weight agents.
Abstract:
The performance of specific inhalation challenge test (SICT) - reference method in diagnostics of occupational allergy - has some limitations due to health status of a particular patient. Therefore, it is extremely important to identify usefulness of other tests, and the evaluation of diagnostic accuracy of commercially available serum specific immunoglobulin E (sIgE) kits to the most common high molecular weight agents has been launched.; The study group comprised 141 subjects - 110 bakers and 31 farmers - with suspicion of occupational airway allergy. All patients underwent evaluation of serum sIgE to occupational allergens with the use of Phadia and Allergopharma kits: in bakers to flour mix and α-amylase, in farmers to epithelium of cow, pig and feathers. Specific inhalation challenge test with workplace allergens performed in all subjects was a reference method for further analysis.; Serum specific IgE to flour mix had the highest sensitivity (Phadia - 95.6%, Allergopharma - 88.3%), while its specificity was relatively low (Phadia - 47.8%, Allergopharma - 25%). There were numerous discrepancies between the results of sIgE estimation for particular single allergens (k87, e4, e83), as well as for their mixtures (fx901, fx20, ex71), performed with the kits of both companies (Phadia vs. Allergopharma).; Evaluation of serum specific IgE is characterized by inadequate sensitivity, specificity and predictive value to take the place of specific inhalation challenge test in diagnostics of occupational respiratory allergy. Med Pr 2017;68(1):31-43.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Journal:
Medycyna Pracy 2017 Feb 28;68(1):31-43.
Issue Date:
28-Feb-2017
URI:
http://hdl.handle.net/10146/618125
DOI:
10.13075/mp.5893.00486
PubMed ID:
28245002
Additional Links:
http://medpr.imp.lodz.pl/Trafnosc-diagnostyczna-oznaczen-alergenowo-swoistych-przeciwcial-IgE-w-zawodowej-alergii-drog-oddechowych-na-czynniki-o-duzej-masie-czasteczkowej,63046,0,2.html
Type:
Article
Language:
pl
ISSN:
0465-5893
Sponsors:
Finansowanie / Funding: praca wykonana w ramach zadania finansowanego z dotacji na działalność statutową nr IMP 12.3 pt. „Standaryzacja metod diagnostyki alergii IgE-zależnej o etiologii zawodowej”. Kierownik tematu: dr hab. n. med. Marta Wiszniewska, prof. IMP.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorZgorzelska-Kowalik, Joannaen
dc.contributor.authorWalusiak-Skorupa, Jolantaen
dc.contributor.authorNowakowska-Swirta, Ewaen
dc.contributor.authorWiszniewska, Martaen
dc.date.accessioned2017-08-22T09:11:32Z-
dc.date.available2017-08-22T09:11:32Z-
dc.date.issued2017-02-28-
dc.identifier.issn0465-5893-
dc.identifier.pmid28245002-
dc.identifier.doi10.13075/mp.5893.00486-
dc.identifier.urihttp://hdl.handle.net/10146/618125-
dc.description.abstractThe performance of specific inhalation challenge test (SICT) - reference method in diagnostics of occupational allergy - has some limitations due to health status of a particular patient. Therefore, it is extremely important to identify usefulness of other tests, and the evaluation of diagnostic accuracy of commercially available serum specific immunoglobulin E (sIgE) kits to the most common high molecular weight agents has been launched.en
dc.description.abstractThe study group comprised 141 subjects - 110 bakers and 31 farmers - with suspicion of occupational airway allergy. All patients underwent evaluation of serum sIgE to occupational allergens with the use of Phadia and Allergopharma kits: in bakers to flour mix and α-amylase, in farmers to epithelium of cow, pig and feathers. Specific inhalation challenge test with workplace allergens performed in all subjects was a reference method for further analysis.en
dc.description.abstractSerum specific IgE to flour mix had the highest sensitivity (Phadia - 95.6%, Allergopharma - 88.3%), while its specificity was relatively low (Phadia - 47.8%, Allergopharma - 25%). There were numerous discrepancies between the results of sIgE estimation for particular single allergens (k87, e4, e83), as well as for their mixtures (fx901, fx20, ex71), performed with the kits of both companies (Phadia vs. Allergopharma).en
dc.description.abstractEvaluation of serum specific IgE is characterized by inadequate sensitivity, specificity and predictive value to take the place of specific inhalation challenge test in diagnostics of occupational respiratory allergy. Med Pr 2017;68(1):31-43.en
dc.description.sponsorshipFinansowanie / Funding: praca wykonana w ramach zadania finansowanego z dotacji na działalność statutową nr IMP 12.3 pt. „Standaryzacja metod diagnostyki alergii IgE-zależnej o etiologii zawodowej”. Kierownik tematu: dr hab. n. med. Marta Wiszniewska, prof. IMP.en
dc.languagepol-
dc.language.isoplen
dc.relation.urlhttp://medpr.imp.lodz.pl/Trafnosc-diagnostyczna-oznaczen-alergenowo-swoistych-przeciwcial-IgE-w-zawodowej-alergii-drog-oddechowych-na-czynniki-o-duzej-masie-czasteczkowej,63046,0,2.htmlen
dc.rightsArchived with thanks to Medycyna pracyen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectairway allergyen
dc.subjectbakersen
dc.subjectdiagnosticsen
dc.subjectfarmersen
dc.subjectoccupational allergyen
dc.subjectserum specific IgE antibodiesen
dc.subject.meshAdult-
dc.subject.meshAir Pollutants, Occupational-
dc.subject.meshAllergens-
dc.subject.meshEnvironmental Monitoring-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunoglobulin E-
dc.subject.meshInhalation Exposure-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshOccupational Diseases-
dc.subject.meshOccupational Exposure-
dc.subject.meshParticulate Matter-
dc.subject.meshRisk Assessment-
dc.subject.meshWorkplace-
dc.titleTrafnosc diagnostyczna oznaczen alergenowo swoistych przeciwcial IgE w zawodowej alergii drog oddechowych na czynniki o duzej masie czasteczkowej.pl
dc.title.alternativeDiagnostic accuracy of specific IgE antibodies measurements in occupational airway allergy to high molecular weight agents.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalMedycyna Pracy 2017 Feb 28;68(1):31-43.en

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