Nanozloto - dzialanie biologiczne i dopuszczalne poziomy narazenia zawodowego.

2.50
Hdl Handle:
http://hdl.handle.net/10146/618120
Title:
Nanozloto - dzialanie biologiczne i dopuszczalne poziomy narazenia zawodowego.
Authors:
Swidwinska-Gajewska, Anna Maria; Czerczak, Sławomir
Other Titles:
Nanogold - Biological effects and occupational exposure levels.
Abstract:
Nanogold has different properties and biological activity compared to metallic gold. It can be applied in many fields, such as medicine, laboratory diagnostics and electronics. Studies on laboratory animals show that nanogold can be absorbed by inhalation and ingestion. It can penetrate deep into the epidermis and dermis, but there is no evidence that it is absorbed through the skin. Gold nanoobjects accumulate mainly in the liver and spleen, but they can also reach other internal organs. Nanogold can cross the blood-brain and blood-placenta barriers. Toxicokinetics of nanogold depends on the particle size, shape and surface charge. In animals exposure to gold nanoparticles via inhalation induces slight changes in the lungs. Exposure to nanogold by the oral route does not cause adverse health effects in rodents. In animals after injection of gold nanoobjects changes in the liver and lungs were observed. Nanogold induced genotoxic effects in cells, but not in animals. No adverse effects on the fetus or reproduction were found. There are no carcinogenicity studies on gold nanoparticles. The mechanism of toxicity may be related to the interaction of gold nanoobjects with proteins and DNA, and it leads to the induction of oxidative stress and genetic material damage. The impact of nanostructures on human health has not yet been fully understood. The person, who works with nanomaterials should exercise extreme caution and apply existing recommendations on the evaluation of nanoobjects exposure. The risk assessment should be the basis for taking appropriate measures to limit potential exposure to nanometals, including nanogold. Med Pr 2017;68(4):545-556.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland
Citation:
Medycyna Pracy 2017, 68 (4):545-556
Journal:
Medycyna Pracy
Issue Date:
27-Jun-2017
URI:
http://hdl.handle.net/10146/618120
DOI:
10.13075/mp.5893.00538
PubMed ID:
28584334
Additional Links:
http://medpr.imp.lodz.pl/Nanozloto-dzialanie-biologiczne-oraz-dopuszczalne-poziomy-narazenia-zawodowego,65958,0,2.html
Type:
Article
Language:
pl
ISSN:
0465-5893
Sponsors:
Funding: w ramach dotacji na działalność statutową, zadanie nr IMP 24.15/2015 pt. „Analiza ryzyka związanego z nanotechnologiami pod kątem wyznaczenia dopuszczalnych poziomów w środowisku pracy dla 4 substancji w postaci nanocząstek”. Kierownik tematu: mgr Anna Maria Świdwińska-Gajewska.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSwidwinska-Gajewska, Anna Mariaen
dc.contributor.authorCzerczak, Sławomiren
dc.date.accessioned2017-08-21T12:36:08Z-
dc.date.available2017-08-21T12:36:08Z-
dc.date.issued2017-06-27-
dc.identifier.citationMedycyna Pracy 2017, 68 (4):545-556en
dc.identifier.issn0465-5893-
dc.identifier.pmid28584334-
dc.identifier.doi10.13075/mp.5893.00538-
dc.identifier.urihttp://hdl.handle.net/10146/618120-
dc.description.abstractNanogold has different properties and biological activity compared to metallic gold. It can be applied in many fields, such as medicine, laboratory diagnostics and electronics. Studies on laboratory animals show that nanogold can be absorbed by inhalation and ingestion. It can penetrate deep into the epidermis and dermis, but there is no evidence that it is absorbed through the skin. Gold nanoobjects accumulate mainly in the liver and spleen, but they can also reach other internal organs. Nanogold can cross the blood-brain and blood-placenta barriers. Toxicokinetics of nanogold depends on the particle size, shape and surface charge. In animals exposure to gold nanoparticles via inhalation induces slight changes in the lungs. Exposure to nanogold by the oral route does not cause adverse health effects in rodents. In animals after injection of gold nanoobjects changes in the liver and lungs were observed. Nanogold induced genotoxic effects in cells, but not in animals. No adverse effects on the fetus or reproduction were found. There are no carcinogenicity studies on gold nanoparticles. The mechanism of toxicity may be related to the interaction of gold nanoobjects with proteins and DNA, and it leads to the induction of oxidative stress and genetic material damage. The impact of nanostructures on human health has not yet been fully understood. The person, who works with nanomaterials should exercise extreme caution and apply existing recommendations on the evaluation of nanoobjects exposure. The risk assessment should be the basis for taking appropriate measures to limit potential exposure to nanometals, including nanogold. Med Pr 2017;68(4):545-556.en
dc.description.sponsorshipFunding: w ramach dotacji na działalność statutową, zadanie nr IMP 24.15/2015 pt. „Analiza ryzyka związanego z nanotechnologiami pod kątem wyznaczenia dopuszczalnych poziomów w środowisku pracy dla 4 substancji w postaci nanocząstek”. Kierownik tematu: mgr Anna Maria Świdwińska-Gajewska.en
dc.languagepol-
dc.language.isoplen
dc.relation.urlhttp://medpr.imp.lodz.pl/Nanozloto-dzialanie-biologiczne-oraz-dopuszczalne-poziomy-narazenia-zawodowego,65958,0,2.htmlen
dc.rightsArchived with thanks to Medycyna pracyen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectnanogolden
dc.subjectnanoobjectsen
dc.subjectnanoparticlesen
dc.subjectoccupational exposureen
dc.subjecttoxicityen
dc.subjecttoxicokineticsen
dc.titleNanozloto - dzialanie biologiczne i dopuszczalne poziomy narazenia zawodowego.pl
dc.title.alternativeNanogold - Biological effects and occupational exposure levels.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Polanden
dc.identifier.journalMedycyna Pracyen

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