Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

2.50
Hdl Handle:
http://hdl.handle.net/10146/617291
Title:
Effect of environmental phthalate exposure on pregnancy duration and birth outcomes
Authors:
Polanska, Kinga ( 0000-0002-3212-2307 ) ; Ligocka, Danuta ( 0000-0001-6075-0792 ) ; Sobala, Wojciech ( 0000-0002-5451-9321 ) ; Hanke, Wojciech ( 0000-0001-7162-2569 )
Abstract:
Objectives: The objective of this study was to evaluate the impact of phthalate exposure on pregnancy duration and birth outcomes based on the Polish Mother and Child Cohort (REPRO_PL). Material and Methods: Phthalate exposure was determined by measuring 11 phthalate metabolites (mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), 3OH-mono-n-butyl phthalate (OH-MnBP), mono-benzyl phthalate (MBzP), mono‑(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-iso-nonyl phthalate (MOiNP), and mono-n-octyl phthalate (MOP)) in the urine collected from 165 mothers during the third trimester of pregnancy by high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The following measures at birth were considered: gestational age, birth weight, length as well as head and chest circumference. Results: Pregnancy duration was inversely associated with natural log concentrations (μg/g creatinine) of MEP (standardized regression coefficient (β) = –0.2, p = 0.04) after adjustment for a variety of confounders. Significant impact of MOiNP on head circumference (β = –0.1, p = 0.05) was also observed. Conclusions: The study findings add further support to the hypothesis that phthalate exposure may be associated with shorter pregnancy duration and a decreased head circumference, and underscore importance of public health interventions to reduce that exposure.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Citation:
Int J Occup Med Environ Health 2016;29(4):683–697
Journal:
International Journal of Occupational Medicine and Environmental Health
Issue Date:
2016
URI:
http://hdl.handle.net/10146/617291
DOI:
10.13075/ijomeh.1896.00691
Additional Links:
http://www.journalssystem.com/ijomeh/Effect-of-environmental-phthalate-exposure-on-pregnancy-duration-and-birth-outcomes,60289,0,2.html; http://ijomeh.eu/Effect-of-environmental-phthalate-exposure-on-pregnancy-duration-and-birth-outcomes,60289,0,2.html
Type:
Article
Language:
en_US
ISSN:
1232-1087
Sponsors:
project No. DEC-2011/01/B/ NZ7/06462
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPolanska, Kingaen
dc.contributor.authorLigocka, Danutaen
dc.contributor.authorSobala, Wojciechen
dc.contributor.authorHanke, Wojciechen
dc.date.accessioned2016-07-21T10:30:32Z-
dc.date.available2016-07-21T10:30:32Z-
dc.date.issued2016-
dc.identifier.citationInt J Occup Med Environ Health 2016;29(4):683–697en
dc.identifier.issn1232-1087-
dc.identifier.doi10.13075/ijomeh.1896.00691-
dc.identifier.urihttp://hdl.handle.net/10146/617291-
dc.description.abstractObjectives: The objective of this study was to evaluate the impact of phthalate exposure on pregnancy duration and birth outcomes based on the Polish Mother and Child Cohort (REPRO_PL). Material and Methods: Phthalate exposure was determined by measuring 11 phthalate metabolites (mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), 3OH-mono-n-butyl phthalate (OH-MnBP), mono-benzyl phthalate (MBzP), mono‑(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-iso-nonyl phthalate (MOiNP), and mono-n-octyl phthalate (MOP)) in the urine collected from 165 mothers during the third trimester of pregnancy by high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The following measures at birth were considered: gestational age, birth weight, length as well as head and chest circumference. Results: Pregnancy duration was inversely associated with natural log concentrations (μg/g creatinine) of MEP (standardized regression coefficient (β) = –0.2, p = 0.04) after adjustment for a variety of confounders. Significant impact of MOiNP on head circumference (β = –0.1, p = 0.05) was also observed. Conclusions: The study findings add further support to the hypothesis that phthalate exposure may be associated with shorter pregnancy duration and a decreased head circumference, and underscore importance of public health interventions to reduce that exposure.en
dc.description.sponsorshipproject No. DEC-2011/01/B/ NZ7/06462en
dc.language.isoen_USen
dc.relation.urlhttp://www.journalssystem.com/ijomeh/Effect-of-environmental-phthalate-exposure-on-pregnancy-duration-and-birth-outcomes,60289,0,2.htmlen
dc.relation.urlhttp://ijomeh.eu/Effect-of-environmental-phthalate-exposure-on-pregnancy-duration-and-birth-outcomes,60289,0,2.htmlen
dc.rightsArchived with thanks to International Journal of Occupational Medicine and Environmental Healthen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectprenatal exposureen
dc.subjectgestational ageen
dc.subjectcohort studyen
dc.subjectphthalatesen
dc.subjecturinary metabolitesen
dc.subjectbirth outcomesen
dc.titleEffect of environmental phthalate exposure on pregnancy duration and birth outcomesen_US
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalInternational Journal of Occupational Medicine and Environmental Healthen
This item is licensed under a Creative Commons License
Creative Commons
All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.