2.50
Hdl Handle:
http://hdl.handle.net/10146/59333
Title:
Inflammation, a key event in cancer development.
Authors:
Lu, Haitian; Ouyang, Weiming; Huang, Chuanshu
Abstract:
Several recent studies have identified nuclear factor-kappaB as a key modulator in driving inflammation to cancers. Besides this transcription factor, essential in regulating inflammation and cancer development, an inflammatory microenvironment inhabiting various inflammatory cells and a network of signaling molecules are also indispensable for the malignant progression of transformed cells, which is attributed to the mutagenic predisposition of persistent infection-fighting agents at sites of chronic inflammation. As a subverted host response to inflammation-induced tumors, the inflammatory cells and regulators may facilitate angiogenesis and promote the growth, invasion, and metastasis of tumor cells. Thus far, research regarding inflammation-associated cancer development has focused on cytokines and chemokines as well as their downstream targets in linking inflammation and cancer. Moreover, other proteins with extensive roles in inflammation and cancer, such as signal transducers and activators of transcription, Nrf2, and nuclear factor of activated T cells, are also proposed to be promising targets for future studies. The elucidation of their specific effects and interactions will accelerate the development of novel therapeutic interventions against cancer development triggered by inflammation.
Citation:
Mol. Cancer Res. 2006, 4 (4):221-233
Journal:
Molecular cancer research : MCR
Issue Date:
Apr-2006
URI:
http://hdl.handle.net/10146/59333
DOI:
10.1158/1541-7786.MCR-05-0261
PubMed ID:
16603636
Additional Links:
http://mcr.aacrjournals.org/cgi/content/full/4/4/221
Type:
Article
Language:
en
Description:
KEYWORDS CLASSIFICATION: Animals;complications;epidemiology;Humans;immunology;Inflammation;metabolism;mechanisms of carcinogenesis;Neoplasms;New York;Research;Signal Transduction;Transcription Factors.
ISSN:
1541-7786
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorLu, Haitian-
dc.contributor.authorOuyang, Weiming-
dc.contributor.authorHuang, Chuanshu-
dc.date.accessioned2009-04-03T07:46:48Z-
dc.date.available2009-04-03T07:46:48Z-
dc.date.issued2006-04-
dc.identifier.citationMol. Cancer Res. 2006, 4 (4):221-233en
dc.identifier.issn1541-7786-
dc.identifier.pmid16603636-
dc.identifier.doi10.1158/1541-7786.MCR-05-0261-
dc.identifier.urihttp://hdl.handle.net/10146/59333-
dc.descriptionKEYWORDS CLASSIFICATION: Animals;complications;epidemiology;Humans;immunology;Inflammation;metabolism;mechanisms of carcinogenesis;Neoplasms;New York;Research;Signal Transduction;Transcription Factors.en
dc.description.abstractSeveral recent studies have identified nuclear factor-kappaB as a key modulator in driving inflammation to cancers. Besides this transcription factor, essential in regulating inflammation and cancer development, an inflammatory microenvironment inhabiting various inflammatory cells and a network of signaling molecules are also indispensable for the malignant progression of transformed cells, which is attributed to the mutagenic predisposition of persistent infection-fighting agents at sites of chronic inflammation. As a subverted host response to inflammation-induced tumors, the inflammatory cells and regulators may facilitate angiogenesis and promote the growth, invasion, and metastasis of tumor cells. Thus far, research regarding inflammation-associated cancer development has focused on cytokines and chemokines as well as their downstream targets in linking inflammation and cancer. Moreover, other proteins with extensive roles in inflammation and cancer, such as signal transducers and activators of transcription, Nrf2, and nuclear factor of activated T cells, are also proposed to be promising targets for future studies. The elucidation of their specific effects and interactions will accelerate the development of novel therapeutic interventions against cancer development triggered by inflammation.en
dc.language.isoenen
dc.relation.urlhttp://mcr.aacrjournals.org/cgi/content/full/4/4/221en
dc.subject.meshAnimals-
dc.subject.meshHumans-
dc.subject.meshInflammation-
dc.subject.meshNeoplasms-
dc.subject.meshSignal Transduction-
dc.subject.meshTranscription Factors-
dc.titleInflammation, a key event in cancer development.en
dc.typeArticleen
dc.identifier.journalMolecular cancer research : MCRen

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