Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene.

2.50
Hdl Handle:
http://hdl.handle.net/10146/581588
Title:
Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene.
Authors:
Swiercz, Radoslaw; Majcherek, Wanda; Wasowicz, Wojciech ( 0000-0002-2991-9040 )
Abstract:
The aim of the study has been to explore hemimellitene distribution in blood, liver, lung and kidney as well as toxicokinetics of its elimination from blood of rats after single and repeated inhalation exposure to this compound. Tissue distribution and excretion with urine of 2-dimethylbenzoic acids (2,3-DMBA and 2,6-DMBA) were also evaluated.; Male outbred IMP:WIST rats were used in the experiment. The animals were exposed to hemimellitene vapors at the nominal concentration of 25 ppm, 100 ppm, and 250 ppm in the dynamic inhalation chambers for 6 h for single exposure purpose and for 4 weeks (6 h/day for 5 day/week) for repeated exposure purposes.; Significantly lower concentrations of hemimellitene were detected in the blood and tissues of animals after repeated inhalation exposure of animals to hemimellitene vapors, which points to reduced retention of the chemical in the lungs of the experimental rats. The trend of hemimellitene elimination from the blood depended solely on exposure intensity, irrespective of exposure time, both after single and repeated exposure. As regards the 2 determined hemimellitene metabolites, the major trend of the metabolic transformation involved formation of 2,3-DMBA.; The significantly higher urinary 2,3-DMBA concentration after repeated exposure shows that hemimellitene induces enzymatic processes in the rat.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Citation:
Int J Occup Med Environ Health. 2016;29(1):113-28
Journal:
International Journal of Occupational Medicine and Environmental Health
Issue Date:
2016
URI:
http://hdl.handle.net/10146/581588
DOI:
10.13075/ijomeh.1896.00599
PubMed ID:
26489948
Additional Links:
http://ijomeh.eu/Hemimellitene-1-2-3-trimethylbenzene-in-the-liver-lung-kidney-and-blood-and-dimethylbenzoic-acid-isomers-in-the-liver-lung-kidney-and-urine-of-rats-after-single-and-repeated-inhalation-exposure-to-hemimellitene,58566,0,2.html
Type:
Article
Language:
en_US
ISSN:
1896-494X
Sponsors:
IMP grant 1.11. “Toxicokinetics and metabolism of hemimellitene after inhalation exposure in rats”
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSwiercz, Radoslawen
dc.contributor.authorMajcherek, Wandaen
dc.contributor.authorWasowicz, Wojciechen
dc.date.accessioned2015-11-03T08:14:57Zen
dc.date.available2015-11-03T08:14:57Zen
dc.date.issued2016en
dc.identifier.citationInt J Occup Med Environ Health. 2016;29(1):113-28en
dc.identifier.issn1896-494Xen
dc.identifier.pmid26489948en
dc.identifier.doi10.13075/ijomeh.1896.00599en
dc.identifier.urihttp://hdl.handle.net/10146/581588en
dc.description.abstractThe aim of the study has been to explore hemimellitene distribution in blood, liver, lung and kidney as well as toxicokinetics of its elimination from blood of rats after single and repeated inhalation exposure to this compound. Tissue distribution and excretion with urine of 2-dimethylbenzoic acids (2,3-DMBA and 2,6-DMBA) were also evaluated.en
dc.description.abstractMale outbred IMP:WIST rats were used in the experiment. The animals were exposed to hemimellitene vapors at the nominal concentration of 25 ppm, 100 ppm, and 250 ppm in the dynamic inhalation chambers for 6 h for single exposure purpose and for 4 weeks (6 h/day for 5 day/week) for repeated exposure purposes.en
dc.description.abstractSignificantly lower concentrations of hemimellitene were detected in the blood and tissues of animals after repeated inhalation exposure of animals to hemimellitene vapors, which points to reduced retention of the chemical in the lungs of the experimental rats. The trend of hemimellitene elimination from the blood depended solely on exposure intensity, irrespective of exposure time, both after single and repeated exposure. As regards the 2 determined hemimellitene metabolites, the major trend of the metabolic transformation involved formation of 2,3-DMBA.en
dc.description.abstractThe significantly higher urinary 2,3-DMBA concentration after repeated exposure shows that hemimellitene induces enzymatic processes in the rat.en
dc.description.sponsorshipIMP grant 1.11. “Toxicokinetics and metabolism of hemimellitene after inhalation exposure in rats”en
dc.language.isoen_USen
dc.relation.urlhttp://ijomeh.eu/Hemimellitene-1-2-3-trimethylbenzene-in-the-liver-lung-kidney-and-blood-and-dimethylbenzoic-acid-isomers-in-the-liver-lung-kidney-and-urine-of-rats-after-single-and-repeated-inhalation-exposure-to-hemimellitene,58566,0,2.htmlen
dc.rightsArchived with thanks to International journal of occupational medicine and environmental healthen
dc.subjectRatsen
dc.subjectHemimelliteneen
dc.subjectPseudocumeneen
dc.subjectMesityleneen
dc.subjectInhalationen
dc.subjectToxicokineticen
dc.titleHemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene.en_US
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalInternational Journal of Occupational Medicine and Environmental Healthen
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