Nanosilver – Occupational exposure limits

2.50
Hdl Handle:
http://hdl.handle.net/10146/576303
Title:
Nanosilver – Occupational exposure limits
Authors:
Swidwinska-Gajewska, Anna; Czerczak, Slawomir
Other Titles:
NANOSREBRO – DOPUSZCZALNE POZIOMY NARAŻENIA ZAWODOWEGO
Abstract:
Historically, nanosilver has been known as colloidal silver composed of particles with a size below 100 nm. Silver nanoparticles are used in many technologies, creating a wide range of products. Due to antibacterial properties nanosilver is used, among others, in medical devices (wound dressings), textiles (sport clothes, socks), plastics and building materials (paints). Colloidal silver is considered by many as an ideal agent in the fight against pathogenic microorganisms, unlike antibiotics, without side effects. However, in light of toxicological research, nanosilver is not inert to the body. The inhalation of silver nanoparticles have an adverse effect mainly on the liver and lung of rats. The oxidative stress caused by reactive oxygen species is responsible for the toxicity of nanoparticles, contributing to cytotoxic and genotoxic effects. The activity of the readily oxidized nanosilver surface underlies the molecular mechanism of toxicity. This leads to the release of silver ions, a known harmful agent. Occupational exposure to silver nanoparticles may occur in the process of its manufacture, formulation and also usage during spraying, in particular. In Poland, as well as in other countries of the world, there is no separate hygiene standards applicable to nanomaterials. The present study attempts to estimate the value of MAC-TWA (maximum admissible concentration – the time-weighted average) for silver – a nano-objects fraction, which amounted to 0.01 mg/m3. The authors are of the opinion that the current value of the MAC-TWA for silver metallic – inhalable fraction (0.05 mg/m3) does not provide sufficient protection against the harmful effects of silver in the form of nano-objects.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Citation:
Medycyna Pracy 2015;66(3):429–442
Journal:
Medycyna Pracy
Issue Date:
2015
URI:
http://hdl.handle.net/10146/576303
DOI:
10.13075/mp.5893.00177
Additional Links:
http://www.journalssystem.com/medpr/NANOSREBRO-DOPUSZCZALNE-POZIOMY-NARAZENIA-ZAWODOWEGO,58326,0,2.html; http://medpr.imp.lodz.pl/Nanosrebro-dopuszczalne-poziomy-narazenia-zawodowego,58326,0,1.html
Type:
Article
Language:
pl
ISSN:
0465-5893
Sponsors:
IMP 24.10/2013
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSwidwinska-Gajewska, Annaen
dc.contributor.authorCzerczak, Slawomiren
dc.date.accessioned2015-09-02T10:38:32Zen
dc.date.available2015-09-02T10:38:32Zen
dc.date.issued2015en
dc.identifier.citationMedycyna Pracy 2015;66(3):429–442en
dc.identifier.issn0465-5893en
dc.identifier.doi10.13075/mp.5893.00177en
dc.identifier.urihttp://hdl.handle.net/10146/576303en
dc.description.abstractHistorically, nanosilver has been known as colloidal silver composed of particles with a size below 100 nm. Silver nanoparticles are used in many technologies, creating a wide range of products. Due to antibacterial properties nanosilver is used, among others, in medical devices (wound dressings), textiles (sport clothes, socks), plastics and building materials (paints). Colloidal silver is considered by many as an ideal agent in the fight against pathogenic microorganisms, unlike antibiotics, without side effects. However, in light of toxicological research, nanosilver is not inert to the body. The inhalation of silver nanoparticles have an adverse effect mainly on the liver and lung of rats. The oxidative stress caused by reactive oxygen species is responsible for the toxicity of nanoparticles, contributing to cytotoxic and genotoxic effects. The activity of the readily oxidized nanosilver surface underlies the molecular mechanism of toxicity. This leads to the release of silver ions, a known harmful agent. Occupational exposure to silver nanoparticles may occur in the process of its manufacture, formulation and also usage during spraying, in particular. In Poland, as well as in other countries of the world, there is no separate hygiene standards applicable to nanomaterials. The present study attempts to estimate the value of MAC-TWA (maximum admissible concentration – the time-weighted average) for silver – a nano-objects fraction, which amounted to 0.01 mg/m3. The authors are of the opinion that the current value of the MAC-TWA for silver metallic – inhalable fraction (0.05 mg/m3) does not provide sufficient protection against the harmful effects of silver in the form of nano-objects.en
dc.description.sponsorshipIMP 24.10/2013en
dc.language.isoplen
dc.relation.urlhttp://www.journalssystem.com/medpr/NANOSREBRO-DOPUSZCZALNE-POZIOMY-NARAZENIA-ZAWODOWEGO,58326,0,2.htmlen
dc.relation.urlhttp://medpr.imp.lodz.pl/Nanosrebro-dopuszczalne-poziomy-narazenia-zawodowego,58326,0,1.htmlen
dc.rightsArchived with thanks to Medycyna Pracyen
dc.subjectNanoparticlesen
dc.subjectOccupational exposureen
dc.subjectSilver, nanoobjectsen
dc.subjectMAC-TWAen
dc.subjectNanosilveren
dc.titleNanosilver – Occupational exposure limitspl
dc.title.alternativeNANOSREBRO – DOPUSZCZALNE POZIOMY NARAŻENIA ZAWODOWEGOen
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalMedycyna Pracyen
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