Preservatives as important etiologic factors of allergic contact dermatitis

2.50
Hdl Handle:
http://hdl.handle.net/10146/576207
Title:
Preservatives as important etiologic factors of allergic contact dermatitis
Authors:
Krecisz, Beata; Chomiczewska-Skora, Dorota; Kiec-Swierczynska, Marta
Other Titles:
KONSERWANTY JAKO ISTOTNE CZYNNIKI ETIOLOGICZNE ALERGICZNEGO KONTAKTOWEGO ZAPALENIA SKÓRY
Abstract:
Background: Preservatives present in cosmetics and other industrial products can cause allergic contact dermatitis. The aim of the study was to assess the frequency of allergy to selected preservatives in consecutive patients examined due to contact dermatitis in the Nofer Institute of Occupational Medicine, Łódź, and to establish whether individuals sensitized to formaldehyde react simultaneously to formaldehyde releasers. Material and Methods: A group of 405 patients (308 females and 97 males) was examined in 2011–2013. In all participants patch tests with a series of 13 preservatives (paraben mix, formaldehyde, Quaternium 15, chloromethylisothiazolinone/methylisothiazolinone mix, methyldibromoglutaronitrile, diazolidinyl urea, imidazolidinyl urea, DMDM hydantoin, 2-bromo-2-nitropropane-1,3-diol, iodopropynyl butylcarbamate, benzalkonium chloride, sodium metabisulfite, produced by Chemotechnique Diagnostics, Sweden) were performed. Results: Of the 405 patients 74 (including 52 females) showed positive results of patch tests. Contact allergy to at least 1 preservative was noted in 47 (11.6%) patients, including 34 (11%) females and 13 (13.4%) males. Methylisothiazolinone proved to be the most frequent sensitizer – 4.7% (5.2% females, 3.1% males) while parabens, 2-bromo-2-nitropropane-1,3-diol and imidazolidinyl urea (0.2%) were found to be the least frequent. Fourteen (3.4%) participants, 10 women and 4 men, were allergic to formaldehyde and/or formaldehyde releasers. In 11 (78.6%) of them monovalent hypersensitivity was observed. In 13 (3.2% of the examined group) patients allergy to preservatives might have been of occupational origin. Conclusions: Preservatives, particularly isothiazolinones, are significant causal factors of allergic contact dermatitis, including occupational cases. Individuals sensitized to formaldehyde may react simultaneously to formaldehyde releasers, however, such reactions are relatively rare.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Citation:
Medycyna Pracy 2015;66(3):327–332
Journal:
Medycyna Pracy
Issue Date:
2015
URI:
http://hdl.handle.net/10146/576207
DOI:
10.13075/mp.5893.00176
Additional Links:
http://www.journalssystem.com/medpr/KONSERWANTY-JAKO-ISTOTNE-CZYNNIKI-ETIOLOGICZNE-ALERGICZNEGO-KONTAKTOWEGO-ZAPALENIA-SKORY,58325,0,2.html; http://medpr.imp.lodz.pl/Konserwanty-jako-istotne-czynniki-etiologiczne-alergicznego-kontaktowego-zapalenia-skory,58325,0,1.html
Type:
Article
Language:
pl
ISSN:
0465-5893
Sponsors:
IMP 11.1 pt. „Reakcje alergiczne skóry i układu oddechowego na konserwanty”.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorKrecisz, Beataen
dc.contributor.authorChomiczewska-Skora, Dorotaen
dc.contributor.authorKiec-Swierczynska, Martaen
dc.date.accessioned2015-09-02T09:49:33Zen
dc.date.available2015-09-02T09:49:33Zen
dc.date.issued2015en
dc.identifier.citationMedycyna Pracy 2015;66(3):327–332en
dc.identifier.issn0465-5893en
dc.identifier.doi10.13075/mp.5893.00176en
dc.identifier.urihttp://hdl.handle.net/10146/576207en
dc.description.abstractBackground: Preservatives present in cosmetics and other industrial products can cause allergic contact dermatitis. The aim of the study was to assess the frequency of allergy to selected preservatives in consecutive patients examined due to contact dermatitis in the Nofer Institute of Occupational Medicine, Łódź, and to establish whether individuals sensitized to formaldehyde react simultaneously to formaldehyde releasers. Material and Methods: A group of 405 patients (308 females and 97 males) was examined in 2011–2013. In all participants patch tests with a series of 13 preservatives (paraben mix, formaldehyde, Quaternium 15, chloromethylisothiazolinone/methylisothiazolinone mix, methyldibromoglutaronitrile, diazolidinyl urea, imidazolidinyl urea, DMDM hydantoin, 2-bromo-2-nitropropane-1,3-diol, iodopropynyl butylcarbamate, benzalkonium chloride, sodium metabisulfite, produced by Chemotechnique Diagnostics, Sweden) were performed. Results: Of the 405 patients 74 (including 52 females) showed positive results of patch tests. Contact allergy to at least 1 preservative was noted in 47 (11.6%) patients, including 34 (11%) females and 13 (13.4%) males. Methylisothiazolinone proved to be the most frequent sensitizer – 4.7% (5.2% females, 3.1% males) while parabens, 2-bromo-2-nitropropane-1,3-diol and imidazolidinyl urea (0.2%) were found to be the least frequent. Fourteen (3.4%) participants, 10 women and 4 men, were allergic to formaldehyde and/or formaldehyde releasers. In 11 (78.6%) of them monovalent hypersensitivity was observed. In 13 (3.2% of the examined group) patients allergy to preservatives might have been of occupational origin. Conclusions: Preservatives, particularly isothiazolinones, are significant causal factors of allergic contact dermatitis, including occupational cases. Individuals sensitized to formaldehyde may react simultaneously to formaldehyde releasers, however, such reactions are relatively rare.en
dc.description.sponsorshipIMP 11.1 pt. „Reakcje alergiczne skóry i układu oddechowego na konserwanty”.en
dc.language.isoplen
dc.relation.urlhttp://www.journalssystem.com/medpr/KONSERWANTY-JAKO-ISTOTNE-CZYNNIKI-ETIOLOGICZNE-ALERGICZNEGO-KONTAKTOWEGO-ZAPALENIA-SKORY,58325,0,2.htmlen
dc.relation.urlhttp://medpr.imp.lodz.pl/Konserwanty-jako-istotne-czynniki-etiologiczne-alergicznego-kontaktowego-zapalenia-skory,58325,0,1.htmlen
dc.rightsArchived with thanks to Medycyna Pracyen
dc.subjectMethylisothiazolinoneen
dc.subjectAllergic contact dermatitisen
dc.subjectPreservativesen
dc.subjectPatch testsen
dc.subjectOccupational dermatitisen
dc.titlePreservatives as important etiologic factors of allergic contact dermatitispl
dc.title.alternativeKONSERWANTY JAKO ISTOTNE CZYNNIKI ETIOLOGICZNE ALERGICZNEGO KONTAKTOWEGO ZAPALENIA SKÓRYen
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalMedycyna Pracyen
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