Occupational exposure to selected isocyanates in Polish industry

2.50
Hdl Handle:
http://hdl.handle.net/10146/576206
Title:
Occupational exposure to selected isocyanates in Polish industry
Authors:
Brzeznicki, Slawomir ( 0000-0002-0542-8538 ) ; Bonczarowska, Marzena
Other Titles:
ZAWODOWE NARAŻENIE NA WYBRANE IZOCYJANIANY W POLSKIM PRZEMYŚLE
Abstract:
Isocyanates constitute a group of highly reactive, low molecular weight chemicals used worldwide for polyurethane manufacturing. The occupational exposure to these compounds is a major cause of occupational asthma, thus it is very important to monitor their concentration in the workplace atmosphere. The aim of the study was to measure the concentration of 4,4’-methylenediphenyl diisocyanate (MDI; CAS 101-68-8), toluene-2,4-di-isocyanate (2,4-TDI; CAS 584-84-9), toluene-2,6-di-isocyanate (2,6-TDI; CAS 91-08-7) and hexamethylene di-isocyanate (HDI; CAS 822-06-0) in the work environment for evaluation of the occupational exposure to these compounds. Material and Methods: Determination of concentrations of selected isocyanates was carried out in 21 manufacturing plants, during different industrial processes. The collected air samples (personal samples) were analyzed by means of the high-performance liquid chromatography (HPLC). Results: The presented results represent the 1st data on the occupational exposure to isocyanates in Poland. This set of data is generally indicative of concentrations of analyzed isocyanates that are low and do not exceed the maximum admissible concentration (MAC) values in Poland. Elevated concentrations (above the MAC value) were found only for the TDI in the course of manufacturing of polyurethane foam blocks. Conclusions: Results of many studies show that low concentrations of isocyanates (particularly of low volatility like for example MDI) in the air cannot exclude the possibility of additional absorption of these compounds through skin. Taking into consideration all the uncertainties associated with the evaluation of the risk of exposure to isocyanates based solely on measurement of their levels in the air, it would seem that the simultaneous application of environmental and biological monitoring would only facilitate a reliable assessment of the occupational exposure risk.
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland
Citation:
Medycyna Pracy 2015;66(3):291–301
Journal:
Medycyna Pracy
Issue Date:
2015
URI:
http://hdl.handle.net/10146/576206
DOI:
10.13075/mp.5893.00020
Additional Links:
http://www.journalssystem.com/medpr/-Zawodowe-narazenie-na-wybrane-izocyjaniany-w-polskim-przemysle-,58273,0,2.html; http://medpr.imp.lodz.pl/Zawodowe-narazenie-na-wybrane-izocyjaniany-w-polskim-przemysle,58273,0,1.html
Type:
Article
Language:
en_US
ISSN:
0465-5893
Sponsors:
IMP 4.8 titled “Evaluation of reliability of selected isocyanates determinations in the air of workplace based on the biological monitoring of their metabolites eliminated with urine.”
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorBrzeznicki, Slawomiren
dc.contributor.authorBonczarowska, Marzenaen
dc.date.accessioned2015-09-02T09:27:59Zen
dc.date.available2015-09-02T09:27:59Zen
dc.date.issued2015en
dc.identifier.citationMedycyna Pracy 2015;66(3):291–301en
dc.identifier.issn0465-5893en
dc.identifier.doi10.13075/mp.5893.00020en
dc.identifier.urihttp://hdl.handle.net/10146/576206en
dc.description.abstractIsocyanates constitute a group of highly reactive, low molecular weight chemicals used worldwide for polyurethane manufacturing. The occupational exposure to these compounds is a major cause of occupational asthma, thus it is very important to monitor their concentration in the workplace atmosphere. The aim of the study was to measure the concentration of 4,4’-methylenediphenyl diisocyanate (MDI; CAS 101-68-8), toluene-2,4-di-isocyanate (2,4-TDI; CAS 584-84-9), toluene-2,6-di-isocyanate (2,6-TDI; CAS 91-08-7) and hexamethylene di-isocyanate (HDI; CAS 822-06-0) in the work environment for evaluation of the occupational exposure to these compounds. Material and Methods: Determination of concentrations of selected isocyanates was carried out in 21 manufacturing plants, during different industrial processes. The collected air samples (personal samples) were analyzed by means of the high-performance liquid chromatography (HPLC). Results: The presented results represent the 1st data on the occupational exposure to isocyanates in Poland. This set of data is generally indicative of concentrations of analyzed isocyanates that are low and do not exceed the maximum admissible concentration (MAC) values in Poland. Elevated concentrations (above the MAC value) were found only for the TDI in the course of manufacturing of polyurethane foam blocks. Conclusions: Results of many studies show that low concentrations of isocyanates (particularly of low volatility like for example MDI) in the air cannot exclude the possibility of additional absorption of these compounds through skin. Taking into consideration all the uncertainties associated with the evaluation of the risk of exposure to isocyanates based solely on measurement of their levels in the air, it would seem that the simultaneous application of environmental and biological monitoring would only facilitate a reliable assessment of the occupational exposure risk.en
dc.description.sponsorshipIMP 4.8 titled “Evaluation of reliability of selected isocyanates determinations in the air of workplace based on the biological monitoring of their metabolites eliminated with urine.”en
dc.language.isoen_USen
dc.relation.urlhttp://www.journalssystem.com/medpr/-Zawodowe-narazenie-na-wybrane-izocyjaniany-w-polskim-przemysle-,58273,0,2.htmlen
dc.relation.urlhttp://medpr.imp.lodz.pl/Zawodowe-narazenie-na-wybrane-izocyjaniany-w-polskim-przemysle,58273,0,1.htmlen
dc.rightsArchived with thanks to Medycyna Pracyen
dc.subjectIsocyanatesen
dc.subjectOccupational exposureen
dc.subjectPolyurethanesen
dc.subject4,4’-methylenediphenyl diisocyanateen
dc.subjecttoluene diisocyanateen
dc.subjecthexamethylene diisocyanateen
dc.titleOccupational exposure to selected isocyanates in Polish industryen_US
dc.title.alternativeZAWODOWE NARAŻENIE NA WYBRANE IZOCYJANIANY W POLSKIM PRZEMYŚLEen
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Polanden
dc.identifier.journalMedycyna Pracyen
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