Occupational exposure to diisocyanates in polyurethane foam factory workers

2.50
Hdl Handle:
http://hdl.handle.net/10146/570775
Title:
Occupational exposure to diisocyanates in polyurethane foam factory workers
Authors:
Swierczynska-Machura, Dominika; Brzeznicki, Slawomir ( 0000-0002-0542-8538 ) ; Nowakowska-Swirta, Ewa; Walusiak-Skorupa, Jolanta ( 0000-0003-0836-6800 ) ; Wittczak, Tomasz; Dudek, Wojciech ( 0000-0002-3502-4227 ) ; Bonczarowska, Marzena; Wesolowski, Wiktor; Czerczak, Slawomir; Palczynski, Cezary
Abstract:
Objectives: The aim of the study was to evaluate health effects of occupational exposure to diisocyanates (DIC) among polyurethane foam products factory workers. Material and Methods: Thirty workers had a physical examination, skin prick tests with common allergens, allergen-specific immunoglobulin E (IgE) antibodies to diisocyanates and pulmonary function tests. Concentrations of selected isocyanates in the workplace air samples as well as concentration of their metabolites in the urine samples collected from the workers of the plant were determined. Results: The most frequent work-related symptoms reported by the examined subjects were rhinitis and skin symptoms. Sensitization to at least 1 common allergen was noted in 26.7% of the subjects. Spirometry changes of bronchial obstruction of a mild degree was observed in 5 workers. The specific IgE antibodies to toluene diisocyanate (TDI) and 4,4’-methylenebis(phenyl isocyanate) (MDI) were not detected in any of the patients’ serum. Cellular profiles of the collected induced sputum (ISP) did not reveal any abnormalities. Air concentrations of TDI isomers ranged 0.2–58.9 μg/m3 and in 7 cases they exceeded the Combined Exposure Index (CEI) value for those compounds. Concentrations of TDI metabolites in post-shift urine samples were significantly higher than in the case of pre-shift urine samples and in 6 cases they exceeded the British Biological Monitoring Guidance Value (BMGV – 1 μmol amine/mol creatinine). We didn’t find a correlation between urinary concentrations of TDI, concentrations in the air and concentrations of toluenediamine (TDA) in the post shift urine samples. Lack of such a correlation may be an effect of the respiratory protective equipment use. Conclusions: Determination of specific IgE in serum is not sensitive enough to serve as a biomarker. Estimation of concentrations of diisocyanate metabolites in urine samples and the presence of work-related allergic symptoms seem to be an adequate method for occupational exposure monitoring of DIC, which may help to determine workers at risk as well as to recognize hazardous workplaces.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland; Medical University of Lodz, Łódź, Poland
Citation:
International Journal of Occupational Medicine and Environmental Health 2015;28(6)
Journal:
International Journal of Occupational Medicine and Environmental Health
Issue Date:
2015
URI:
http://hdl.handle.net/10146/570775
DOI:
10.13075/ijomeh.1896.00284
Additional Links:
http://www.journalssystem.com/ijomeh/OCCUPATIONAL-EXPOSURE-TO-DIISOCYANATES-IN-POLYURETHANE-FOAM-FACTORY-WORKERS,58489,0,2.html; http://ijomeh.eu/Occupational-exposure-to-diisocyanates-in-polyurethane-foam-factory-workers,58489,0,2.html
Type:
Article
Language:
en_US
ISSN:
1232-1087
Sponsors:
local statutory funds IMP 11.4 “Assessment of the health effects of inhalation exposure to diisocyanates among factory workers polyurethane foam” and IMP 4.8 entitled “Evaluation of reliability of chosen isocyanates determinations in the air of workplace based on the biological monitoring of their metabolites eliminated with urine”
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSwierczynska-Machura, Dominikaen
dc.contributor.authorBrzeznicki, Slawomiren
dc.contributor.authorNowakowska-Swirta, Ewaen
dc.contributor.authorWalusiak-Skorupa, Jolantaen
dc.contributor.authorWittczak, Tomaszen
dc.contributor.authorDudek, Wojciechen
dc.contributor.authorBonczarowska, Marzenaen
dc.contributor.authorWesolowski, Wiktoren
dc.contributor.authorCzerczak, Slawomiren
dc.contributor.authorPalczynski, Cezaryen
dc.date.accessioned2015-08-17T11:08:08Zen
dc.date.available2015-08-17T11:08:08Zen
dc.date.issued2015en
dc.identifier.citationInternational Journal of Occupational Medicine and Environmental Health 2015;28(6)en
dc.identifier.issn1232-1087en
dc.identifier.doi10.13075/ijomeh.1896.00284en
dc.identifier.urihttp://hdl.handle.net/10146/570775en
dc.description.abstractObjectives: The aim of the study was to evaluate health effects of occupational exposure to diisocyanates (DIC) among polyurethane foam products factory workers. Material and Methods: Thirty workers had a physical examination, skin prick tests with common allergens, allergen-specific immunoglobulin E (IgE) antibodies to diisocyanates and pulmonary function tests. Concentrations of selected isocyanates in the workplace air samples as well as concentration of their metabolites in the urine samples collected from the workers of the plant were determined. Results: The most frequent work-related symptoms reported by the examined subjects were rhinitis and skin symptoms. Sensitization to at least 1 common allergen was noted in 26.7% of the subjects. Spirometry changes of bronchial obstruction of a mild degree was observed in 5 workers. The specific IgE antibodies to toluene diisocyanate (TDI) and 4,4’-methylenebis(phenyl isocyanate) (MDI) were not detected in any of the patients’ serum. Cellular profiles of the collected induced sputum (ISP) did not reveal any abnormalities. Air concentrations of TDI isomers ranged 0.2–58.9 μg/m3 and in 7 cases they exceeded the Combined Exposure Index (CEI) value for those compounds. Concentrations of TDI metabolites in post-shift urine samples were significantly higher than in the case of pre-shift urine samples and in 6 cases they exceeded the British Biological Monitoring Guidance Value (BMGV – 1 μmol amine/mol creatinine). We didn’t find a correlation between urinary concentrations of TDI, concentrations in the air and concentrations of toluenediamine (TDA) in the post shift urine samples. Lack of such a correlation may be an effect of the respiratory protective equipment use. Conclusions: Determination of specific IgE in serum is not sensitive enough to serve as a biomarker. Estimation of concentrations of diisocyanate metabolites in urine samples and the presence of work-related allergic symptoms seem to be an adequate method for occupational exposure monitoring of DIC, which may help to determine workers at risk as well as to recognize hazardous workplaces.en
dc.description.sponsorshiplocal statutory funds IMP 11.4 “Assessment of the health effects of inhalation exposure to diisocyanates among factory workers polyurethane foam” and IMP 4.8 entitled “Evaluation of reliability of chosen isocyanates determinations in the air of workplace based on the biological monitoring of their metabolites eliminated with urine”en
dc.language.isoen_USen
dc.relation.urlhttp://www.journalssystem.com/ijomeh/OCCUPATIONAL-EXPOSURE-TO-DIISOCYANATES-IN-POLYURETHANE-FOAM-FACTORY-WORKERS,58489,0,2.htmlen
dc.relation.urlhttp://ijomeh.eu/Occupational-exposure-to-diisocyanates-in-polyurethane-foam-factory-workers,58489,0,2.htmlen
dc.rightsArchived with thanks to International Journal of Occupational Medicine and Environmental Healthen
dc.subjectBiomarkersen
dc.subjectDiisocyanatesen
dc.subjectAsthmaen
dc.subjectPolyurethanesen
dc.subjectBiological monitoringen
dc.subjectOccupational exposureen
dc.subjectOccupational diseasesen
dc.titleOccupational exposure to diisocyanates in polyurethane foam factory workersen_US
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Poland; Medical University of Lodz, Łódź, Polanden
dc.identifier.journalInternational Journal of Occupational Medicine and Environmental Healthen
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