Bladder cancer mortality and private well use in New England: an ecological study.

2.50
Hdl Handle:
http://hdl.handle.net/10146/57057
Title:
Bladder cancer mortality and private well use in New England: an ecological study.
Authors:
Ayotte, Joseph D.; Baris, Dalsu; Cantor, Kenneth P.; Colt, Joanne; Robinson, Gilpin R.; Lubin, Jay H.; Karagas, Margaret; Hoover, Robert N.; Fraumeni, Joseph F.; Silverman, Debra T.
Abstract:
STUDY OBJECTIVE: To investigate the possible relation between bladder cancer mortality among white men and women and private water use in New England, USA, where rates have been persistently raised and use of private water supplies (wells) common. DESIGN: Ecological study relating age adjusted cancer mortality rates for white men and women during 1985-1999 and proportion of persons using private water supplies in 1970. After regressing mortality rates on population density, Pearson correlation coefficients were computed between residual rates and the proportion of the population using private water supplies, using the state economic area as the unit of calculation. Calculations were conducted within each of 10 US regions. SETTING: The 504 state economic areas of the contiguous United States. PARTICIPANTS: Mortality analysis of 11 cancer sites, with the focus on bladder cancer. MAIN RESULTS: After adjusting for the effect of population density, there was a statistically significant positive correlation between residual bladder cancer mortality rates and private water supply use among both men and women in New England (men, r = 0.42; women, r = 0.48) and New York/New Jersey (men, r = 0.49; women, r = 0.62). CONCLUSIONS: Use of well water from private sources, or a close correlate, may be an explanatory variable for the excess bladder cancer mortality in New England. Analytical studies are underway to clarify the relation between suspected water contaminants, particularly arsenic, and raised bladder cancer rates in northern New England.
Citation:
J Epidemiol Community Health 2006, 60 (2):168-172
Journal:
Journal of epidemiology and community health
Issue Date:
Feb-2006
URI:
http://hdl.handle.net/10146/57057
DOI:
10.1136/jech.2005.038620
PubMed ID:
16415269
Additional Links:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16415269; http://jech.bmj.com/cgi/content/abstract/60/2/168
Type:
Article
Language:
en
Description:
Cancer epidemiologyCancer type: bladder cancerStudy design: cross-sectionalStudy size: 379548Description of cohort(s) studied: individuals from 504 state economic areas in 10 US regionsExposure(s) evaluated: private waterConfounders controlled for: sexImpact on risk: Among men, bladder cancer rate residuals were significantly correlated with private well use in New England (region 1), as well as in regions 2 (NY and NJ) and 8 (six Western states), P<0.05Among women, significant associations for bladder cancer mortality residuals were found in New England and region 2, P<0.05. KEYWORDS CLASSIFICATION: adverse effects;analysis;Adult;cancer epidemiology;Carcinogens;Carcinogens,Environmental;dietary modulation of cancer & cancer biomarkers;epidemiology;etiology;England;Environmental Exposure;European Continental Ancestry Group;Female;Humans;mortality;Male;Middle Aged;New England;Research;United States;Urinary Bladder Neoplasms;Water;Water Supply.
ISSN:
0143-005X
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorAyotte, Joseph D.-
dc.contributor.authorBaris, Dalsu-
dc.contributor.authorCantor, Kenneth P.-
dc.contributor.authorColt, Joanne-
dc.contributor.authorRobinson, Gilpin R.-
dc.contributor.authorLubin, Jay H.-
dc.contributor.authorKaragas, Margaret-
dc.contributor.authorHoover, Robert N.-
dc.contributor.authorFraumeni, Joseph F.-
dc.contributor.authorSilverman, Debra T.-
dc.date.accessioned2009-03-25T10:10:21Z-
dc.date.available2009-03-25T10:10:21Z-
dc.date.issued2006-02-
dc.identifier.citationJ Epidemiol Community Health 2006, 60 (2):168-172en
dc.identifier.issn0143-005X-
dc.identifier.pmid16415269-
dc.identifier.doi10.1136/jech.2005.038620-
dc.identifier.urihttp://hdl.handle.net/10146/57057-
dc.descriptionCancer epidemiologyCancer type: bladder cancerStudy design: cross-sectionalStudy size: 379548Description of cohort(s) studied: individuals from 504 state economic areas in 10 US regionsExposure(s) evaluated: private waterConfounders controlled for: sexImpact on risk: Among men, bladder cancer rate residuals were significantly correlated with private well use in New England (region 1), as well as in regions 2 (NY and NJ) and 8 (six Western states), P<0.05Among women, significant associations for bladder cancer mortality residuals were found in New England and region 2, P<0.05. KEYWORDS CLASSIFICATION: adverse effects;analysis;Adult;cancer epidemiology;Carcinogens;Carcinogens,Environmental;dietary modulation of cancer & cancer biomarkers;epidemiology;etiology;England;Environmental Exposure;European Continental Ancestry Group;Female;Humans;mortality;Male;Middle Aged;New England;Research;United States;Urinary Bladder Neoplasms;Water;Water Supply.en
dc.description.abstractSTUDY OBJECTIVE: To investigate the possible relation between bladder cancer mortality among white men and women and private water use in New England, USA, where rates have been persistently raised and use of private water supplies (wells) common. DESIGN: Ecological study relating age adjusted cancer mortality rates for white men and women during 1985-1999 and proportion of persons using private water supplies in 1970. After regressing mortality rates on population density, Pearson correlation coefficients were computed between residual rates and the proportion of the population using private water supplies, using the state economic area as the unit of calculation. Calculations were conducted within each of 10 US regions. SETTING: The 504 state economic areas of the contiguous United States. PARTICIPANTS: Mortality analysis of 11 cancer sites, with the focus on bladder cancer. MAIN RESULTS: After adjusting for the effect of population density, there was a statistically significant positive correlation between residual bladder cancer mortality rates and private water supply use among both men and women in New England (men, r = 0.42; women, r = 0.48) and New York/New Jersey (men, r = 0.49; women, r = 0.62). CONCLUSIONS: Use of well water from private sources, or a close correlate, may be an explanatory variable for the excess bladder cancer mortality in New England. Analytical studies are underway to clarify the relation between suspected water contaminants, particularly arsenic, and raised bladder cancer rates in northern New England.en
dc.language.isoenen
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16415269en
dc.relation.urlhttp://jech.bmj.com/cgi/content/abstract/60/2/168en
dc.subjectBladder canceren
dc.subjectDrinking wateren
dc.subjectPrivate water supplyen
dc.subjectNew Englanden
dc.subject.meshAdult-
dc.subject.meshCarcinogens, Environmental-
dc.subject.meshEnvironmental Exposure-
dc.subject.meshEuropean Continental Ancestry Group-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNew England-
dc.subject.meshUrinary Bladder Neoplasms-
dc.subject.meshWater Supply-
dc.titleBladder cancer mortality and private well use in New England: an ecological study.en
dc.typeArticleen
dc.identifier.journalJournal of epidemiology and community healthen

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