Endotoxin exposure and changes in short-term pulmonary function among sewage workers

2.50
Hdl Handle:
http://hdl.handle.net/10146/565711
Title:
Endotoxin exposure and changes in short-term pulmonary function among sewage workers
Authors:
Cyprowski, Marcin; Sobala, Wojciech ( 0000-0002-5451-9321 ) ; Buczynska, Alina; Szadkowska-Stanczyk, Irena
Abstract:
Objectives: The inhaled endotoxin is considered as a causative factor in the process of acute bronchial obstruction, which can be measured by a decrease in forced expiratory volume in 1 s (FEV1). The aim of this study was to assess endotoxin exposure among sewage treatment plant workers (STPW) and its effect on across-shift changes in respiratory airflow. Material and Methods: A group of 78 STPW from a large sewage treatment plant was studied. Inhalable dust for endotoxin assessment was collected using personal aerosol samplers. Endotoxin was assayed with the kinetic, chromogenic Limulus amebocyte lysate test. Across-shift spirometric measurements were performed on Mondays, after 2-days absence from work, with the use of portable spirometer. The forced vital capacity (FVC), and FEV1 parameters were analyzed. Multifactor regression modeling was performed to determine parameters significantly associated with endotoxin exposure. Results: The concentration of inhalable dust and endotoxin ranged from 0.01–1.38 mg/m3 and 0.68–214 endotoxin units per cubic meter of air (EU/m3), respectively. Endotoxins were characterized with the skewed distribution (arithmetic mean (AM) = 38.8 EU/m3, geometric mean (GM) = 15.4 EU/m3, geometric standard deviation (GSD) = 4.21). Through the use of multifactor analysis, which excluded the main confounders (inhalable dust and smoking habit) it was found that, despite low levels of endotoxin, it had significant impact on the observed across-shift decline in FEV1 (p = 0.044). For this parameter, the regression slope was additionally calculated (r = –0.017, p = 0.071). Conclusions: Relatively low levels of endotoxin among sewage treatment plant workers may cause small, but significant across-shift declines in FEV1. The observed relationship was independent of organic dust concentrations and smoking habit. The respiratory protection should be provided for STPW.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland; Central Institute for Labour Protection – National Research Institute, Warszawa, Poland
Citation:
International Journal of Occupational Medicine and Environmental Health 2015;28(5):803 – 811
Journal:
International Journal of Occupational Medicine and Environmental Health
Issue Date:
2015
URI:
http://hdl.handle.net/10146/565711
DOI:
10.13075/ijomeh.1896.00460
Additional Links:
http://www.journalssystem.com/ijomeh/ENDOTOXIN-EXPOSURE-AND-CHANGES-IN-SHORT-TERM-PULMONARY-FUNCTION-AMONG-SEWAGE-WORKERS,58543,0,2.html; http://ijomeh.eu/Endotoxin-exposure-and-changes-in-short-term-pulmonary-function-among-sewage-workers,58543,0,2.html
Type:
Article
Language:
en_US
ISSN:
1232-1087
Sponsors:
Award Number 5D43 TW000621-10 from the Fogarty International Center
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorCyprowski, Marcinen
dc.contributor.authorSobala, Wojciechen
dc.contributor.authorBuczynska, Alinaen
dc.contributor.authorSzadkowska-Stanczyk, Irenaen
dc.date.accessioned2015-08-07T07:53:46Zen
dc.date.available2015-08-07T07:53:46Zen
dc.date.issued2015en
dc.identifier.citationInternational Journal of Occupational Medicine and Environmental Health 2015;28(5):803 – 811en
dc.identifier.issn1232-1087en
dc.identifier.doi10.13075/ijomeh.1896.00460en
dc.identifier.urihttp://hdl.handle.net/10146/565711en
dc.description.abstractObjectives: The inhaled endotoxin is considered as a causative factor in the process of acute bronchial obstruction, which can be measured by a decrease in forced expiratory volume in 1 s (FEV1). The aim of this study was to assess endotoxin exposure among sewage treatment plant workers (STPW) and its effect on across-shift changes in respiratory airflow. Material and Methods: A group of 78 STPW from a large sewage treatment plant was studied. Inhalable dust for endotoxin assessment was collected using personal aerosol samplers. Endotoxin was assayed with the kinetic, chromogenic Limulus amebocyte lysate test. Across-shift spirometric measurements were performed on Mondays, after 2-days absence from work, with the use of portable spirometer. The forced vital capacity (FVC), and FEV1 parameters were analyzed. Multifactor regression modeling was performed to determine parameters significantly associated with endotoxin exposure. Results: The concentration of inhalable dust and endotoxin ranged from 0.01–1.38 mg/m3 and 0.68–214 endotoxin units per cubic meter of air (EU/m3), respectively. Endotoxins were characterized with the skewed distribution (arithmetic mean (AM) = 38.8 EU/m3, geometric mean (GM) = 15.4 EU/m3, geometric standard deviation (GSD) = 4.21). Through the use of multifactor analysis, which excluded the main confounders (inhalable dust and smoking habit) it was found that, despite low levels of endotoxin, it had significant impact on the observed across-shift decline in FEV1 (p = 0.044). For this parameter, the regression slope was additionally calculated (r = –0.017, p = 0.071). Conclusions: Relatively low levels of endotoxin among sewage treatment plant workers may cause small, but significant across-shift declines in FEV1. The observed relationship was independent of organic dust concentrations and smoking habit. The respiratory protection should be provided for STPW.en
dc.description.sponsorshipAward Number 5D43 TW000621-10 from the Fogarty International Centeren
dc.language.isoen_USen
dc.relation.urlhttp://www.journalssystem.com/ijomeh/ENDOTOXIN-EXPOSURE-AND-CHANGES-IN-SHORT-TERM-PULMONARY-FUNCTION-AMONG-SEWAGE-WORKERS,58543,0,2.htmlen
dc.relation.urlhttp://ijomeh.eu/Endotoxin-exposure-and-changes-in-short-term-pulmonary-function-among-sewage-workers,58543,0,2.htmlen
dc.rightsArchived with thanks to International Journal of Occupational Medicine and Environmental Healthen
dc.subjectsewage workersen
dc.subjectendotoxin exposureen
dc.subjectinhalable dusten
dc.subjectsmokingen
dc.subjectlung functionen
dc.subjectRegression Analysisen
dc.titleEndotoxin exposure and changes in short-term pulmonary function among sewage workersen_US
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Poland; Central Institute for Labour Protection – National Research Institute, Warszawa, Polanden
dc.identifier.journalInternational Journal of Occupational Medicine and Environmental Healthen
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