CYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10146/56163
Title:
CYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma.
Authors:
Esinler, I.; Aktas, D.; Alikasifoglu, M.; Tuncbilek, E.; Ayhan, A.
Abstract:
The cytochrome P4501A1 (CYP1A1) is involved in the metabolism of environmental carcinogens and estrogen. We hypothesized that CYP1A1 genetic polymorphism may be a susceptibility factor for endometrial hyperplasia (EH) and endometrial carcinoma (ECa). We therefore evaluated this hypothesis in patients with EH and ECa and control subjects using allele-specific polymerase chain reaction-based method in a Turkish population. The patients with CYP1A1 Ile/Val genotype had a fivefold higher risk of having EH than those with Ile/Ile. In contrast, a higher frequency of any Val genotype (Ile/Val and Val/Val) was found in patients with EH, indicating that persons carrying any Val allele are at increased risk for developing EH. In the ECa group, patients were also more likely to have CYP1A1 Ile/Val allele, with an adjusted odds ratio of 3.0. Moreover, there was a statistically significant increase in relative risk association with any Val genotype between patients and controls, suggesting that individuals carrying any Val genotype are at increased risk for developing ECa. We concluded that variant alleles of the CYP1A1 gene might be associated with EH and ECa susceptibility. Further studies with a large sample size should be considered to address issues of interactions between CYP1A1 and other risk factors.
Citation:
Int. J. Gynecol. Cancer, 2006 16 (3):1407-1411
Journal:
International Journal of Gynecological Cancer : official journal of the International Gynecological Cancer Society
Issue Date:
18-Mar-2009
URI:
http://hdl.handle.net/10146/56163
DOI:
10.1111/j.1525-1438.2006.00605.x
PubMed ID:
16803538
Additional Links:
http://www3.interscience.wiley.com/journal/118632224/abstract
Type:
Article
Language:
en
Description:
Biomarkers of individual susceptibility: field studies. Biomarker: CYP1A1 genetic polymorphism [the homozygous wild type (Ile/Ile); the heterozygous variant (Ile/Val); the homozygous variant (Val/Val)]Effect studied: endometrial hyperplasia (EH); endometrial carcinoma (ECa)Tissue/biological material/sample size: blood. Method of analysis: allele-specific polymerase chain reactionStudy design: case-control study. Study size: 59 cases with simple EH (cystic without atypia); 94 cases with endometrioid type of ECa; 202 controls. Impact on outcome (including dose-response): The patients with CYP1A1 Ile/Val genotype had a fivefold higher risk of having EH than those with Ile/Ile. In contrast, a higher frequency of any Val genotype (Ile/Val and Val/Val) was found in patients with EH, indicating that persons carrying any Val allele are at increased risk for developing EH. In the ECa group, patients were also more likely to have CYP1A1 Ile/Val allele, with an adjusted odds ratio of 3.0. Moreover, there was a statistically significant increase in relative risk association with any Val genotype between patients and controls, suggesting that individuals carrying any Val genotype are at increased risk for developing ECa.Quality control:The PCR analysis was performed at least twice for each sample. All the analyzed cases were reviewed by the same pathologist. KEYWORDS - CLASIFFICATION: Adult;Aged;Alleles;analysis;biomarkers of individual susceptibility: field studies;blood;cancer epidemiology;Carcinoma,Endometrioid;Case-Control Studies;Cytochrome P-450 CYP1A1;Endometrial Hyperplasia;Endometrial Neoplasms;epidemiology;Female;field studies;Gene Frequency;genetic;Genetic Predisposition to Disease;genetics;Genotype;history;Humans;metabolism;Middle Aged;Polymorphism,Genetic;Risk Factors;Turkey;
ISSN:
1048-891X
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorEsinler, I.-
dc.contributor.authorAktas, D.-
dc.contributor.authorAlikasifoglu, M.-
dc.contributor.authorTuncbilek, E.-
dc.contributor.authorAyhan, A.-
dc.date.accessioned2009-03-18T11:43:03Z-
dc.date.available2009-03-18T11:43:03Z-
dc.date.issued2009-03-18T11:43:03Z-
dc.identifier.citationInt. J. Gynecol. Cancer, 2006 16 (3):1407-1411en
dc.identifier.issn1048-891X-
dc.identifier.pmid16803538-
dc.identifier.doi10.1111/j.1525-1438.2006.00605.x-
dc.identifier.urihttp://hdl.handle.net/10146/56163-
dc.descriptionBiomarkers of individual susceptibility: field studies. Biomarker: CYP1A1 genetic polymorphism [the homozygous wild type (Ile/Ile); the heterozygous variant (Ile/Val); the homozygous variant (Val/Val)]Effect studied: endometrial hyperplasia (EH); endometrial carcinoma (ECa)Tissue/biological material/sample size: blood. Method of analysis: allele-specific polymerase chain reactionStudy design: case-control study. Study size: 59 cases with simple EH (cystic without atypia); 94 cases with endometrioid type of ECa; 202 controls. Impact on outcome (including dose-response): The patients with CYP1A1 Ile/Val genotype had a fivefold higher risk of having EH than those with Ile/Ile. In contrast, a higher frequency of any Val genotype (Ile/Val and Val/Val) was found in patients with EH, indicating that persons carrying any Val allele are at increased risk for developing EH. In the ECa group, patients were also more likely to have CYP1A1 Ile/Val allele, with an adjusted odds ratio of 3.0. Moreover, there was a statistically significant increase in relative risk association with any Val genotype between patients and controls, suggesting that individuals carrying any Val genotype are at increased risk for developing ECa.Quality control:The PCR analysis was performed at least twice for each sample. All the analyzed cases were reviewed by the same pathologist. KEYWORDS - CLASIFFICATION: Adult;Aged;Alleles;analysis;biomarkers of individual susceptibility: field studies;blood;cancer epidemiology;Carcinoma,Endometrioid;Case-Control Studies;Cytochrome P-450 CYP1A1;Endometrial Hyperplasia;Endometrial Neoplasms;epidemiology;Female;field studies;Gene Frequency;genetic;Genetic Predisposition to Disease;genetics;Genotype;history;Humans;metabolism;Middle Aged;Polymorphism,Genetic;Risk Factors;Turkey;en
dc.description.abstractThe cytochrome P4501A1 (CYP1A1) is involved in the metabolism of environmental carcinogens and estrogen. We hypothesized that CYP1A1 genetic polymorphism may be a susceptibility factor for endometrial hyperplasia (EH) and endometrial carcinoma (ECa). We therefore evaluated this hypothesis in patients with EH and ECa and control subjects using allele-specific polymerase chain reaction-based method in a Turkish population. The patients with CYP1A1 Ile/Val genotype had a fivefold higher risk of having EH than those with Ile/Ile. In contrast, a higher frequency of any Val genotype (Ile/Val and Val/Val) was found in patients with EH, indicating that persons carrying any Val allele are at increased risk for developing EH. In the ECa group, patients were also more likely to have CYP1A1 Ile/Val allele, with an adjusted odds ratio of 3.0. Moreover, there was a statistically significant increase in relative risk association with any Val genotype between patients and controls, suggesting that individuals carrying any Val genotype are at increased risk for developing ECa. We concluded that variant alleles of the CYP1A1 gene might be associated with EH and ECa susceptibility. Further studies with a large sample size should be considered to address issues of interactions between CYP1A1 and other risk factors.en
dc.language.isoenen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/118632224/abstracten
dc.subjectCYP1A1en
dc.subjectEndometrial carcinomaen
dc.subjectEndometrial hyperplasiaen
dc.subjectEstrogenen
dc.subjectPolymorphismen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCarcinoma, Endometrioid-
dc.subject.meshCase-Control Studies-
dc.subject.meshCytochrome P-450 CYP1A1-
dc.subject.meshEndometrial Hyperplasia-
dc.subject.meshEndometrial Neoplasms-
dc.subject.meshFemale-
dc.subject.meshGene Frequency-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenotype-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshRisk Factors-
dc.titleCYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma.en
dc.typeArticleen
dc.identifier.journalInternational Journal of Gynecological Cancer : official journal of the International Gynecological Cancer Societyen

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